Publications by authors named "Thomas Downes"

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Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.
Thomas D Downes, S Paul Jones, James D Firth, John F Darby, Amelia K Gilio

Chem Sci· October 2025

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Applicability of the electronic frailty index in younger and older adults in England: a population-based cohort study.
Daniel R Morales, Bruce Guthrie, Thomas J Downes, David A McAllister, Peter Hanlon

Lancet Healthy Longev· August 2025

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Health conditions in adults with atrial fibrillation compared with the general population: a population-based cross-sectional analysis.
Thomas J Downes, Bruce Guthrie, David Moreno-Martos, Daniel R Morales

Heart· June 2025

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Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors.
Jack R Davison, Michalis Hadjithomas, Stuart P Romeril, Yoon Jong Choi, Keith W Bentley, Thomas D Downes

J Med Chem· August 2024

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Understanding Effects of Visual Feedback Delay in AR on Fine Motor Surgical Tasks.
Talha Khan, Toby S Zhu, Thomas Downes, Lucille Cheng, Nicolas M Kass

IEEE Trans Vis Comput Graph· November 2023

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, Thomas D Downes

Nat Commun· October 2020

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Design and Synthesis of 56 Shape-Diverse 3D Fragments.
Thomas D Downes, S Paul Jones, Hanna F Klein, Mary C Wheldon, Masakazu Atobe

Chemistry· July 2020

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Symptomatic Course of Foot Osteoarthritis Phenotypes: An 18-Month Prospective Analysis of Community-Dwelling Older Adults.
Thomas J Downes, Linda Chesterton, Rebecca Whittle, Edward Roddy, Hylton B Menz

Arthritis Care Res (Hoboken)· July 2018

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Pathophysiology, Diagnosis, and Management of Chronic Intestinal Pseudo-Obstruction.
Thomas J Downes, Manikandar S Cheruvu, Tennekoon B Karunaratne, Roberto De Giorgio, Adam D Farmer

J Clin Gastroenterol· July 2018

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Pathophysiology, diagnosis, and management of opioid-induced constipation.
Adam D Farmer, Caroline Bruckner Holt, Thomas J Downes, Eugenio Ruggeri, Sara Del Vecchio

Lancet Gastroenterol Hepatol· March 2018

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Investigations of Potential Phenotypes of Foot Osteoarthritis: Cross-Sectional Analysis From the Clinical Assessment Study of the Foot.
Trishna Rathod, Michelle Marshall, Martin J Thomas, Hylton B Menz, Helen L Myers, Thomas Downes

Arthritis Care Res (Hoboken)· February 2016

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Fracture rates in Parkinson's disease compared with age- and gender-matched controls: a retrospective cohort study.
Richard W Genever, Thomas W Downes, Pippa Medcalf

Age Ageing· January 2005

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