Publications by authors named "Thomas Garner"

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Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.
Jin Du, Elisia Villemure, Matthew Johnson, Caleigh Azumaya, Catarina J Gaspar, Thomas Garner

Nat Commun· December 2025

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Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer.
Mericka McCabe, Rajanya Bhattacharyya, Rebecca Sereda, Olaya Santiago-Fernández, Rabia R Khawaja, Thomas P Garner

EMBO Mol Med· July 2025

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Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Jun Liang, Michael J Lambrecht, Teresita L Arenzana, Samuel Aubert-Nicol, Linda Bao, Thomas Garner

ACS Med Chem Lett· June 2024

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Modulating mitofusins to control mitochondrial function and signaling.
Emmanouil Zacharioudakis, Bogos Agianian, Vasantha Kumar Mv, Nikolaos Biris, Thomas P Garner

Nat Commun· July 2022

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Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.
Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P Garner

Nat Commun· July 2022

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Eltrombopag directly inhibits BAX and prevents cell death.
Adam Z Spitz, Emmanouil Zacharioudakis, Denis E Reyna, Thomas P Garner, Evripidis Gavathiotis

Nat Commun· February 2021

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A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy.
Dulguun Amgalan, Thomas P Garner, Ryan Pekson, Xiaotong F Jia, Mounica Yanamandala

Nat Cancer· March 2020

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BCL-2 Protein Family Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy.
Thomas P Garner, Evripidis Gavathiotis

Methods Mol Biol· May 2019

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Small-molecule allosteric inhibitors of BAX.
Thomas P Garner, Dulguun Amgalan, Denis E Reyna, Sheng Li, Richard N Kitsis

Nat Chem Biol· April 2019

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Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.
Denis E Reyna, Thomas P Garner, Andrea Lopez, Felix Kopp, Gaurav S Choudhary

Cancer Cell· October 2017

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Progress in targeting the BCL-2 family of proteins.
Thomas P Garner, Andrea Lopez, Denis E Reyna, Adam Z Spitz, Evripidis Gavathiotis

Curr Opin Chem Biol· August 2017

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Co-exposure to sunlight enhances the toxicity of naturally weathered Deepwater Horizon oil to early lifestage red drum (Sciaenops ocellatus) and speckled seatrout (Cynoscion nebulosus).
Matthew Alloy, Thomas Ross Garner, Kristin Bridges, Charles Mansfield, Michael Carney

Environ Toxicol Chem· March 2017

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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Thomas P Garner, Denis E Reyna, Amit Priyadarshi, Hui-Chen Chen, Sheng Li

Mol Cell· October 2016

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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Thomas P Garner, Denis E Reyna, Amit Priyadarshi, Hui-Chen Chen, Sheng Li

Mol Cell· August 2016

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A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki.
Horia Negulescu, Youzhong Guo, Thomas P Garner, Octavia Y Goodwin, Gregg Henderson

PLoS One· March 2016

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Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Lauren A Barclay, Thomas E Wales, Thomas P Garner, Franziska Wachter, Susan Lee

Mol Cell· March 2015

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Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.
Rongshi Li, Chunwei Cheng, Maria E Balasis, Yan Liu, Thomas P Garner

Eur J Med Chem· January 2015

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Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.
Chunwei Cheng, Yan Liu, Maria E Balasis, Thomas P Garner, Jerry Li

Mar Drugs· July 2014

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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.
Sara Iachettini, Malcolm Fg Stevens, Mark Frigerio, Marc G Hummersone, Ian Hutchinson, Thomas P Garner

J Exp Clin Cancer Res· September 2013

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Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives.
Jaime Anguiano, Thomas P Garner, Murugesan Mahalingam, Bhaskar C Das, Evripidis Gavathiotis

Nat Chem Biol· June 2013

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Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.
Mark S Searle, Thomas P Garner, Joanna Strachan, Jed Long, Jennifer Adlington

Biochem Soc Trans· April 2012

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Insights into the molecular composition of endogenous unanchored polyubiquitin chains.
Joanna Strachan, Lucy Roach, Kleitos Sokratous, David Tooth, Jed Long, Thomas P Garner

J Proteome Res· March 2012

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Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex.
Thomas P Garner, Joanna Strachan, Elizabeth C Shedden, Jed E Long, James R Cavey

Biochemistry· October 2011

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Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.
Hideyuki Takeuchi, Rodrigo C Fernández-Valdivia, Devin S Caswell, Aleksandra Nita-Lazar, Nadia A Rana, Thomas P Garner

Proc Natl Acad Sci U S A· October 2011

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Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.
Thomas P Garner, Jed Long, Robert Layfield, Mark S Searle

Biochemistry· May 2011

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