Publications by authors named "Thomas Graeber"

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Clinical and molecular characterization of in colorectal cancer, CALGB (Alliance)/SWOG 80405 and real-world data.
Karam Ashouri, Joshua Millstein, Yan Yang, Joanne Xiu, Shivani Soni, Thomas G Graeber

J Immunother Cancer· December 2025

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Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance.
Claire M Storey, Mohamed Altai, Katharina Lückerath, Wahed Zedan, Henan Zhu, Thomas G Graeber

Signal Transduct Target Ther· September 2025

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Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma.
Suresh Udutha, Céline Taglang, Georgios Batsios, Anne Marie Gillespie, Meryssa Tran, Thomas G Graeber

Cell Rep· May 2025

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Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression.
Sara Huerta-Yepez, Po-Chun Chen, Kawaljit Kaur, Yash Jain, Tanya Singh, Thomas G Graeber

BMJ Oncol· April 2025

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Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer.
Shan Li, Kai Song, Huiyun Sun, Yong Tao, Arthur Huang, Thomas G Graeber

bioRxiv· March 2025

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The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling.
Anthony E Jones, Amy Rios, Neira Ibrahimovic, Carolina Chavez, Nicholas A Bayley, Thomas G Graeber

bioRxiv· January 2025

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WITHDRAWN: Single-Cell Heterogeneity of EGFR Pathway Is Linked to Unique Signatures of Drug Response and Malignancy in Patient Derived Glioblastoma Stem Cells.
Michael D Masterman-Smith, Nicholas A Graham, Eduard H Panosyan, Jack Mottahedeh, Eric R Samuels, Thomas G Graeber

Cancer Res Treat· January 2025

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PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.
Grigor Varuzhanyan, Chia-Chun Chen, Jack Freeland, Tian He, Wendy Tran, Thomas G Graeber

Proc Natl Acad Sci U S A· December 2024

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Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities.
Jack Freeland, Maria Muñoz, Edmond O'Donnell, Justin Langerman, Morgan Darrow, Thomas G Graeber

Clin Cancer Res· November 2024

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A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction.
Shen Li, Bo Tao, Jijun Wan, Enca Montecino-Rodriguez, Ping Wang, Thomas Graeber

Cell Rep Med· November 2024

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Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma.
Elizabeth G Fernandez, Wilson X Mai, Kai Song, Nicholas A Bayley, Jiyoon Kim, Thomas G Graeber

Nat Commun· November 2024

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Oncogenic pathway signatures predict the risk of progression and recurrence in well-differentiated pancreatic neuroendocrine tumors.
Michael A Mederos, Colin M Court, Benjamin J Dipardo, Joseph R Pisegna, David W Dawson, Thomas G Graeber

J Surg Oncol· October 2024

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MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.
Elisabeth Roider, Alexandra I T Lakatos, Alicia M McConnell, Poguang Wang, Alina Mueller, Thomas G Graeber

Sci Rep· September 2024

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Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma.
Kyle D Klingbeil, Blake R Wilde, Danielle S Graham, Serena Lofftus, Tyler McCaw, Thomas G Graeber

Cancers (Basel)· August 2024

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PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity.
Grigor Varuzhanyan, Chia-Chun Chen, Jack Freeland, Tian He, Wendy Tran, Thomas Graeber

bioRxiv· July 2024

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Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.
Chia-Chun Chen, Wendy Tran, Kai Song, Tyler Sugimoto, Matthew B Obusan, Thomas G Graeber

Cancer Cell· December 2023

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Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
Deborah A Knight, Shin Foong Ngiow, Ming Li, Tiffany Parmenter, Stephen Mok, Thomas G Graeber

J Clin Invest· December 2023

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A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation.
Amelia Palermo, Shen Li, Johanna Ten Hoeve, Akshay Chellappa, Alexandra Morris, Thomas G Graeber

Commun Biol· November 2023

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MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species.
Elisabeth Roider, Alexandra I T Lakatos, Alicia M McConnell, Poguang Wang, Alina Mueller, Thomas G Graeber

bioRxiv· November 2023

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Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas.
Suresh Udutha, Céline Taglang, Georgios Batsios, Anne Marie Gillespie, Meryssa Tran, Thomas G Graeber

bioRxiv· November 2023

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CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis.
Jenna K Minami, Danielle Morrow, Nicholas A Bayley, Elizabeth G Fernandez, Jennifer J Salinas, Thomas G Graeber

Cancer Cell· June 2023

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Fibroblast Activation Protein Expression in Sarcomas.
Jacquelyn N Crane, Danielle S Graham, Christine E Mona, Scott D Nelson, Alireza Samiei, Thomas G Graeber

Sarcoma· June 2023

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Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma.
Junhui Hu, Ping Tan, Moe Ishihara, Nicholas A Bayley, Shiruyeh Schokrpur, Thomas G Graeber

Signal Transduct Target Ther· April 2023

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Targeting PEA3 transcription factors to mitigate small cell lung cancer progression.
David W Shia, WooSuk Choi, Preethi Vijayaraj, Valarie Vuong, Jenna M Sandlin, Thomas G Graeber

Oncogene· February 2023

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Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function.
Neal K Bennett, Hiroki J Nakaoka, Danny Laurent, Ross A Okimoto, Yoshitaka Sei, Thomas G Graeber

PLoS Biol· September 2022

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