Publications by authors named "Thomas Ladd"

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Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease.
Yona Levites, Eric B Dammer, Yong Ran, Wangchen Tsering, Duc Duong, Thomas Ladd

Cell Rep Med· August 2024

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Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease.
Yona Levites, Eric B Dammer, Yong Ran, Wangchen Tsering, Duc Duong, Thomas B Ladd

bioRxiv· December 2023

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Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo.
Karen N McFarland, Carolina Ceballos, Awilda Rosario, Thomas Ladd, Brenda Moore

Life Sci Alliance· July 2021

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Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.
Yona Levites, Cory Funk, Xue Wang, Paramita Chakrabarty, Karen N McFarland, Thomas Ladd

Mol Neurodegener· May 2021

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γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
Christian B Lessard, Edgardo Rodriguez, Thomas B Ladd, Lisa M Minter, Barbara A Osborne

Alzheimers Res Ther· May 2020

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An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
Hunter S Futch, Karen N McFarland, Brenda D Moore, M Zino Kuhn, Benoit I Giasson, Thomas B Ladd

J Exp Med· November 2019

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Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
Lawrence X Cai, Yohei Tanada, Gregory D Bello, James C Fleming, Fariz F Alkassis, Thomas Ladd

Sci Rep· August 2019

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Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
Christian B Lessard, Edgardo Rodriguez, Thomas B Ladd, Lisa M Minter, Barbara A Osborne

J Biol Chem· July 2019

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APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.
Carole Deyts, Mary Clutter, Nicholas Pierce, Paramita Chakrabarty, Thomas B Ladd

Cell Rep· April 2019

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Designing antibodies against LRRK2-targeted tau epitopes.
Matthew Hamm, Thomas B Ladd, Yona Levites, Todd E Golde, Benoit I Giasson

PLoS One· March 2019

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High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz

EMBO Mol Med· November 2018

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TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.
Paramita Chakrabarty, Andrew Li, Thomas B Ladd, Michael R Strickland, Emily J Koller

J Exp Med· September 2018

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Short Aβ peptides attenuate Aβ42 toxicity in vivo.
Brenda D Moore, Jason Martin, Lorena de Mena, Jonatan Sanchez, Pedro E Cruz, Thomas B Ladd

J Exp Med· January 2018

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Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.
Joo In Jung, Sasha Premraj, Pedro E Cruz, Thomas B Ladd, Yewon Kwak

PLoS One· January 2016

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Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.
Joo In Jung, Ashleigh R Price, Thomas B Ladd, Yong Ran, Hyo-Jin Park

Mol Neurodegener· July 2015

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Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.
Nicola J Rutherford, Amanda N Sacino, Mieu Brooks, Carolina Ceballos-Diaz, Thomas B Ladd

Mol Neurodegener· July 2015

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Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
Joo In Jung, Yong Ran, Pedro E Cruz, Awilda M Rosario, Thomas B Ladd

Biochemistry· April 2014

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γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.
Yong Ran, Pedro E Cruz, Thomas B Ladd, Abdul H Fauq, Joo In Jung

J Biol Chem· February 2014

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Steroids as γ-secretase modulators.
Joo In Jung, Thomas B Ladd, Thomas Kukar, Ashleigh R Price, Brenda D Moore

FASEB J· September 2013

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Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.
Yanxia Liu, Wei Zhang, Li Li, Lilibeth A Salvador, Tiantian Chen, Thomas B Ladd

J Med Chem· December 2012

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Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
Hyo-Jin Park, Daniil Shabashvili, Michael D Nekorchuk, Eva Shyqyriu, Joo In Jung, Thomas B Ladd

J Biol Chem· November 2012

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Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.
Brenda D Moore, Paramita Chakrabarty, Yona Levites, Tom L Kukar, Ann-Marie Baine, Thomas B Ladd

Alzheimers Res Ther· May 2012

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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
Thomas L Kukar, Thomas B Ladd, Paul Robertson, Sean A Pintchovski, Brenda Moore

J Biol Chem· November 2011

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Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Eva Czirr, Barbara A Cottrell, Stefanie Leuchtenberger, Thomas Kukar, Thomas B Ladd

J Biol Chem· June 2008

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Substrate-targeting gamma-secretase modulators.
Thomas L Kukar, Thomas B Ladd, Maralyssa A Bann, Patrick C Fraering, Rajeshwar Narlawar

Nature· June 2008

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