Publications by authors named "Thomas Poulos"

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Redox Partner Recognition and Selectivity of Cytochrome P450terp (CYP108A1).
Jessica A Gable, Thomas L Poulos, Alec H Follmer

Biochemistry· December 2025

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Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Dhananjayan Vasu, Ha T Do, Huiying Li, Christine D Hardy, Thomas L Poulos

Bioorg Med Chem· July 2025

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A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor with an Unprecedented Binding Mode.
Pathum M Weerawarna, Huiying Li, Athri D Rathnayake, Christine D Hardy, Thomas L Poulos

ACS Med Chem Lett· April 2025

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Crystal structure of cytochrome P450 NysL and the structural basis for stereo- and regio-selective oxidation of antifungal macrolides.
Vidhi C Murarka, Jenny S Kim, David C Lamb, Steven L Kelly, Thomas L Poulos

J Biol Chem· March 2025

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Application of the Linear Interaction Energy Method to Nitric Oxide Synthase Structure-Based Inhibitor Design.
Alec H Follmer, Thomas L Poulos

J Chem Inf Model· November 2024

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Biosynthesis of a new skyllamycin in : a cytochrome P450 forms an epoxide in the cinnamoyl chain.
Yuhao Song, Jose A Amaya, Vidhi C Murarka, Hugo Mendez, Mark Hogan, Thomas L Poulos

Org Biomol Chem· April 2024

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Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Thomas L Poulos

Biochemistry· March 2024

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Redox partner recognition and selectivity of cytochrome P450lin (CYP111A1).
Jessica A Gable, Thomas L Poulos, Alec H Follmer

J Inorg Biochem· July 2023

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Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.
Dhananjayan Vasu, Ha T Do, Huiying Li, Christine D Hardy, Amardeep Awasthi, Thomas L Poulos

J Med Chem· July 2023

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Predicting the environmental fates of emerging contaminants: Synergistic effects in ozone reactions of nitrogen-containing alkenes.
Xinke Wang, Weihong Wang, Lisa M Wingen, Véronique Perraud, Michael J Ezell, Thomas L Poulos

Sci Adv· March 2023

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Cooperative Substrate Binding Controls Catalysis in Bacterial Cytochrome P450terp (CYP108A1).
Jessica A Gable, Thomas L Poulos, Alec H Follmer

J Am Chem Soc· February 2023

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2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
Dhananjayan Vasu, Huiying Li, Christine D Hardy, Thomas L Poulos, Richard B Silverman

Bioorg Med Chem· September 2022

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Structural Insights on the Conversion of Cytochrome P450 to P420.
Jessica A Gable, Sarvind Tripathi, Thomas L Poulos

ACS Omega· June 2022

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Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s.
Jose A Amaya, David C Lamb, Steven L Kelly, Patrick Caffrey, Vidhi C Murarka, Thomas L Poulos

J Biol Chem· April 2022

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Computational analysis of the tryptophan cation radical energetics in peroxidase Compound I.
Thomas L Poulos, Jenny S Kim, Vidhi C Murarka

J Biol Inorg Chem· March 2022

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Updating the Paradigm: Redox Partner Binding and Conformational Dynamics in Cytochromes P450.
Thomas L Poulos, Alec H Follmer

Acc Chem Res· February 2022

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Partial Opening of Cytochrome P450cam (CYP101A1) Is Driven by Allostery and Putidaredoxin Binding.
Simon P Skinner, Alec H Follmer, Marcellus Ubbink, Thomas L Poulos, Jeanine J Houwing-Duistermaat

Biochemistry· October 2021

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Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1.
José A Amaya, Dipanwita Batabyal, Thomas L Poulos

Biochemistry· August 2020

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Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases.
Vidhi C Murarka, Dipanwita Batabyal, Jose A Amaya, Irina F Sevrioukova, Thomas L Poulos

Biochemistry· July 2020

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First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
Maris A Cinelli, Cory T Reidl, Huiying Li, Georges Chreifi, Thomas L Poulos

J Med Chem· May 2020

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Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution.
Shih-Wei Chuo, Shu-Hao Liou, Lee-Ping Wang, R David Britt, Thomas L Poulos

Biochemistry· September 2019

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On the occurrence of cytochrome P450 in viruses.
David C Lamb, Alec H Follmer, Jared V Goldstone, David R Nelson, Andrew G Warrilow, Thomas L Poulos

Proc Natl Acad Sci U S A· June 2019

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Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
Ha T Do, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman

J Med Chem· March 2019

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Ligand and Redox Partner Binding Generates a New Conformational State in Cytochrome P450cam (CYP101A1).
Alec H Follmer, Sarvind Tripathi, Thomas L Poulos

J Am Chem Soc· February 2019

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Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
Maris A Cinelli, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman

J Med Chem· January 2019

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