Publications by authors named "Thomas Ryckmans"

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From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation.
Vladas Oleinikovas, Pablo Gainza, Thomas Ryckmans, Bernhard Fasching, Nicolas H Thomä

Annu Rev Pharmacol Toxicol· January 2024

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Identification of novel scaffolds targeting Mycobacterium tuberculosis.
Michael Dal Molin, Petra Selchow, Daniel Schäfle, Andreas Tschumi, Thomas Ryckmans

J Mol Med (Berl)· November 2019

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Anti-biofilm Agents against : A Structure-Activity Relationship Study of -Glycosidic LecB Inhibitors.
Roman Sommer, Katharina Rox, Stefanie Wagner, Dirk Hauck, Sarah S Henrikus, Thomas Ryckmans

J Med Chem· October 2019

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Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa.
Roman Sommer, Stefanie Wagner, Katharina Rox, Annabelle Varrot, Dirk Hauck, Thomas Ryckmans

J Am Chem Soc· February 2018

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Highly potent and selective Na1.7 inhibitors for use as intravenous agents and chemical probes.
R Ian Storer, Andy Pike, Nigel A Swain, Aristos J Alexandrou, Bruce M Bechle, Thomas Ryckmans

Bioorg Med Chem Lett· November 2017

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The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
Sarah E Skerratt, Mark Andrews, Sharan K Bagal, James Bilsland, David Brown, Thomas Ryckmans

J Med Chem· November 2016

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TAK1 inhibition in the DFG-out conformation.
Iain Kilty, Martin P Green, Andrew S Bell, David G Brown, Peter G Dodd, Thomas Ryckmans

Chem Biol Drug Des· November 2013

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Application of Barluenga Boronic Coupling (BBC) to the parallel synthesis of drug-like and drug fragment-like molecules.
Shoko Nakagawa, Katie A Bainbridge, Ken Butcher, Dave Ellis, Wolfgang Klute, Thomas Ryckmans

ChemMedChem· February 2012

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Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study.
Anisha Wijeyesekera, Philip A Clarke, Magda Bictash, Ian J Brown, Mark Fidock, Thomas Ryckmans

Anal Methods· January 2012

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Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.
Patrick S Johnson, Thomas Ryckmans, Justin Bryans, Dave M Beal, Kevin N Dack

Bioorg Med Chem Lett· October 2011

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Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.
Thomas Ryckmans, Aisah A Aubdool, Jennifer V Bodkin, Peter Cox, Susan D Brain

Bioorg Med Chem Lett· August 2011

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Modulation of the vasopressin system for the treatment of CNS diseases.
Thomas Ryckmans

Curr Opin Drug Discov Devel· September 2010

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N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.
Florian Wakenhut, Gill A Allan, Paul V Fish, M Jonathan Fray, Anthony C Harrison, Thomas Ryckmans

Bioorg Med Chem Lett· September 2009

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Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.
Thomas Ryckmans, Martin P Edwards, Val A Horne, Ana Monica Correia, Dafydd R Owen

Bioorg Med Chem Lett· August 2009

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Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.
Paul V Fish, Florian Wakenhut, Thomas Ryckmans, Alan Stobie

Bioorg Med Chem Lett· August 2009

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2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology.
Dafydd R Owen, Margarita Rodriguez-Lens, Martin D Corless, Steven M Gaulier, Valerie A Horne, Thomas Ryckmans

Bioorg Med Chem Lett· March 2009

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Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.
Paul V Fish, Nancy S Barta, David L F Gray, Thomas Ryckmans, Alan Stobie

Bioorg Med Chem Lett· August 2008

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Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.
Paul V Fish, Christopher Deur, Xinmin Gan, Keri Greene, David Hoople, Thomas Ryckmans

Bioorg Med Chem Lett· April 2008

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[4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.
Paul V Fish, Thomas Ryckmans, Alan Stobie, Florian Wakenhut

Bioorg Med Chem Lett· March 2008

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A concise total synthesis of the lichen macrolide (+)-aspicilin.
Christophe Dubost, Istvan E Markó, Thomas Ryckmans

Org Lett· October 2006

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Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.
Thomas Ryckmans, Olivier Berton, Renée Grimée, Thierry Kogej, Yves Lamberty

Bioorg Med Chem Lett· November 2002

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First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants.
Thomas Ryckmans, Laurent Balançon, Olivier Berton, Christophe Genicot, Yves Lamberty

Bioorg Med Chem Lett· January 2002

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