Publications by authors named "Magda Bictash"

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Identification of novel small molecule chaperone activators for neurodegenerative disease treatment.
Anita K Ho, Fiona Jeganathan, Magda Bictash, Han-Jou Chen

Biomed Pharmacother· June 2025

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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.
Marc P M Soutar, Daniela Melandri, Benjamin O'Callaghan, Emily Annuario, Amy E Monaghan, Magda Bictash

Brain· December 2022

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Structural Analysis and Development of Notum Fragment Screening Hits.
Yuguang Zhao, William Mahy, Nicky J Willis, Hannah L Woodward, David Steadman, Magda Bictash

ACS Chem Neurosci· July 2022

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Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Nicky J Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L Woodward, Magda Bictash

J Med Chem· May 2022

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Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
David Steadman, Benjamin N Atkinson, Yuguang Zhao, Nicky J Willis, Sarah Frew, Magda Bictash

J Med Chem· January 2022

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Structural Insights into Notum Covalent Inhibition.
Yuguang Zhao, Fredrik Svensson, David Steadman, Sarah Frew, Amy Monaghan, Magda Bictash

J Med Chem· August 2021

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TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.
Lorenza Magno, Tom D Bunney, Emma Mead, Fredrik Svensson, Magda N Bictash

Mol Neurodegener· April 2021

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Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in .
Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Magda Bictash

Elife· March 2021

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Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding.
Gabriel H S Dreiman, Magda Bictash, Paul V Fish, Lewis Griffin, Fredrik Svensson

SLAS Discov· February 2021

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5-Phenyl-1,3,4-oxadiazol-2(3)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
William Mahy, Nicky J Willis, Yuguang Zhao, Hannah L Woodward, Fredrik Svensson, Magda Bictash

J Med Chem· November 2020

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Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
William Mahy, Mikesh Patel, David Steadman, Hannah L Woodward, Benjamin N Atkinson, Magda Bictash

J Med Chem· September 2020

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Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Benjamin N Atkinson, David Steadman, William Mahy, Yuguang Zhao, James Sipthorp, Magda Bictash

Bioorg Med Chem Lett· February 2020

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Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Benjamin N Atkinson, David Steadman, Yuguang Zhao, James Sipthorp, Luca Vecchia, Magda Bictash

Medchemcomm· August 2019

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Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons.
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, Julia Rodrigues, Kaur Alasoo, Magda Bictash

Nat Genet· July 2019

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Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration.
Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis, Julie Kerby, Yvonne H Luo, Magda Bictash

Nat Biotechnol· April 2018

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Molecular and functional variation in iPSC-derived sensory neurons.
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, Julia Rodrigues, Kaur Alasoo, Magda Bictash

Nat Genet· January 2018

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Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.
Parul Choudhary, Alex Gutteridge, Emma Impey, R Ian Storer, Robert M Owen, Magda Bictash

Stem Cells Transl Med· July 2016

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Urinary metabolic signatures of human adiposity.
Paul Elliott, Joram M Posma, Queenie Chan, Isabel Garcia-Perez, Anisha Wijeyesekera, Magda Bictash

Sci Transl Med· April 2015

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Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.
Gareth T Young, Alex Gutteridge, Heather DE Fox, Anna L Wilbrey, Lishuang Cao, Magda Bictash

Mol Ther· August 2014

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Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study.
Anisha Wijeyesekera, Philip A Clarke, Magda Bictash, Ian J Brown, Mark Fidock

Anal Methods· January 2012

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In vitro and in vivo pharmacological characterisation of the potent and selective vasopressin V(1A) receptor antagonist 4-[4-(4-Chloro-phenyl)-5-[1,2,3]triazol-2-ylmethyl-4H-[1,2,4]triazol-3-yl]-piperidin-1-yl-(3,5-difluoro-phenyl) methanone (PF-00738245).
Rachel Russell, Rachel Doyle, Jamie Turner, Neil Attkins, Simeon Ramsey, Magda Bictash

Eur J Pharmacol· November 2011

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Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.
Ivan K S Yap, Ian J Brown, Queenie Chan, Anisha Wijeyesekera, Isabel Garcia-Perez, Magda Bictash

J Proteome Res· December 2010

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Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology.
Magda Bictash, Timothy M Ebbels, Queenie Chan, Ruey Leng Loo, Ivan K S Yap

J Clin Epidemiol· September 2010

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Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption.
Silke S Heinzmann, Ian J Brown, Queenie Chan, Magda Bictash, Marc-Emmanuel Dumas

Am J Clin Nutr· August 2010

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Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents.
Jasmina Saric, Jia V Li, Jonathan R Swann, Jürg Utzinger, Gail Calvert, Magda Bictash

J Proteome Res· May 2010

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