Publications by authors named "Timothy A Haystead"

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Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis.
Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, Timothy Aj Haystead

JCI Insight· July 2023

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Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice.
Istvan Tamas, Evelin Major, Daniel Horvath, Ilka Keller, Adam Ungvari, Timothy A Haystead

Mol Cell Endocrinol· July 2022

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Transcription factor-driven alternative localization of Cryptococcus neoformans superoxide dismutase.
Aaron D Smith, Sarela Garcia-Santamarina, Martina Ralle, David R Loiselle, Timothy A Haystead

J Biol Chem· September 2021

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The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
Mark R Woodford, Alexander J Baker-Williams, Rebecca A Sager, Sarah J Backe, Adam R Blanden, Timothy A Haystead

Nat Struct Mol Biol· August 2021

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Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.
Bushu Dong, Alex M Jaeger, Philip F Hughes, David R Loiselle, J Spencer Hauck, Timothy A Haystead

Sci Transl Med· December 2020

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Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors.
Kensuke Kaneko, Takuya Osada, Michael A Morse, William R Gwin, Joshua D Ginzel, Timothy Aj Haystead

Commun Biol· May 2020

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Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
Rebecca A Sager, Mark R Woodford, Sarah J Backe, Alan M Makedon, Alexander J Baker-Williams, Timothy A Haystead

Cell Rep· January 2019

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Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity.
Dora Posfai, Amber L Eubanks, Allison I Keim, Kuan-Yi Lu, Grace Z Wang, Timothy A Haystead

Antimicrob Agents Chemother· April 2018

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Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.
Natela Dushukyan, Diana M Dunn, Rebecca A Sager, Mark R Woodford, David R Loiselle, Timothy A Haystead

Cell Rep· November 2017

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Cellular fatty acid synthase is required for late stages of HIV-1 replication.
Manjusha M Kulkarni, Annette N Ratcliff, Menakshi Bhat, Yazan Alwarawrah, Philip Hughes, Timothy A Haystead

Retrovirology· September 2017

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Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.
Mackenzie D Martin, Jeremy D Baker, Amirthaa Suntharalingam, Bryce A Nordhues, Lindsey B Shelton, Timothy A J Haystead

ACS Chem Biol· July 2016

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An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target.
Matthew K Howe, Brittany L Speer, Philip F Hughes, David R Loiselle, Subhash Vasudevan, Timothy A J Haystead

Antiviral Res· June 2016

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Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.
Yazan Alwarawrah, Philip Hughes, David Loiselle, David A Carlson, David B Darr, Timothy A J Haystead

Cell Chem Biol· June 2016

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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
Mark R Woodford, Diana M Dunn, Adam R Blanden, Dante Capriotti, David Loiselle, Timothy A Haystead

Nat Commun· June 2016

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A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle.
Justin A MacDonald, Cindy Sutherland, David A Carlson, Sabreena Bhaidani, Abdulhameed Al-Ghabkari, Timothy A J Haystead

Mol Pharmacol· January 2016

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c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.
Diana M Dunn, Mark R Woodford, Andrew W Truman, Sandra M Jensen, Jacqualyn Schulman, Timothy A Haystead

Cell Rep· August 2015

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Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice.
Beata Lontay, Khaldon Bodoor, Adrienn Sipos, Douglas H Weitzel, David Loiselle, Timothy A Haystead

J Biol Chem· July 2015

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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
Matthew K Howe, Khaldon Bodoor, David A Carlson, Philip F Hughes, Yazan Alwarawrah, Timothy A J Haystead

Chem Biol· December 2014

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Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.
David A Carlson, Aaron S Franke, Douglas H Weitzel, Brittany L Speer, Philip F Hughes, Timothy A J Haystead

ACS Chem Biol· December 2013

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Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.
Jared J Barrott, Philip F Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C Hartman, Timothy A Haystead

Chem Biol· September 2013

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Hsp90, an unlikely ally in the war on cancer.
Jared J Barrott, Timothy A J Haystead

FEBS J· March 2013

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A highly selective Hsp90 affinity chromatography resin with a cleavable linker.
Philip F Hughes, Jared J Barrott, David A Carlson, David R Loiselle, Brittany L Speer, Timothy A J Haystead

Bioorg Med Chem· May 2012

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Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP.
James S Duncan, Timothy A J Haystead, David W Litchfield

Methods Mol Biol· January 2012

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Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy.
Khaldon Bodoor, Beata Lontay, Rachid Safi, Douglas H Weitzel, David Loiselle, Timothy A Haystead

J Biol Chem· September 2011

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Efficient detection of RNA-protein interactions using tethered RNAs.
Hidekazu Iioka, David Loiselle, Timothy A Haystead, Ian G Macara

Nucleic Acids Res· April 2011

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