Publications by authors named "Timothy A Vortherms"

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Suppression of superoxide/hydrogen peroxide production at mitochondrial site I decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.
Mark A Watson, Harmanmeet Brar, Edwin T Gibbs, Hoi-Shan Wong, Pratiksha A Dighe, Timothy A Vortherms

Free Radic Biol Med· August 2023

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Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222.
Ashvani K Singh, Yihong Fan, Corina Balut, Sara Alani, Arlene M Manelli, Timothy A Vortherms

J Pharmacol Exp Ther· January 2020

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Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
Chang Z Zhu, Timothy A Vortherms, Min Zhang, Jun Xu, Andrew M Swensen

J Pain· April 2014

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Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain.
Xenia Beebe, Clinton M Yeung, Daria Darczak, Shashank Shekhar, Timothy A Vortherms

Bioorg Med Chem Lett· September 2013

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An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.
Andrew M Swensen, Wende Niforatos, Timothy A Vortherms, Richard J Perner, Tao Li

Assay Drug Dev Technol· December 2012

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A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats.
Victoria E Scott, Timothy A Vortherms, Wende Niforatos, Andrew M Swensen, Torben Neelands

Biochem Pharmacol· February 2012

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Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.
George A Doherty, Pramila Bhatia, Timothy A Vortherms, Kennan C Marsh, Jill M Wetter

Bioorg Med Chem Lett· February 2012

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Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels.
Timothy A Vortherms, Andrew M Swensen, Wende Niforatos, James T Limberis, Torben R Neelands

Inflamm Res· July 2011

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Cloning and characterization of the monkey histamine H3 receptor isoforms.
Marina I Strakhova, Gerard B Fox, Tracy L Carr, David G Witte, Timothy A Vortherms

Eur J Pharmacol· December 2008

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cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Huaqing Liu, Robert J Altenbach, Tracy L Carr, Prasant Chandran, Gin C Hsieh, Timothy A Vortherms

J Med Chem· November 2008

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Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
Robert J Altenbach, Ronald M Adair, Brian M Bettencourt, Lawrence A Black, Shannon R Fix-Stenzel, Timothy A Vortherms

J Med Chem· October 2008

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In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Diana L Nersesian, Lawrence A Black, Thomas R Miller, Timothy A Vortherms, Timothy A Esbenshade

Bioorg Med Chem Lett· January 2008

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Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.
Timothy A Vortherms, Philip D Mosier, Richard B Westkaemper, Bryan L Roth

J Biol Chem· February 2007

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Salvinorin A: from natural product to human therapeutics.
Timothy A Vortherms, Bryan L Roth

Mol Interv· October 2006

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D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is G alpha(s) independent.
Timothy A Vortherms, Chau H Nguyen, Murat Bastepe, Harald Jüppner, Val J Watts

Neuropharmacology· April 2006

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Autoxidation of salvinorin A under basic conditions.
Thomas A Munro, Glenn W Goetchius, Bryan L Roth, Timothy A Vortherms, Mark A Rizzacasa

J Org Chem· November 2005

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Receptorome screening for CNS drug discovery.
Timothy A Vortherms, Bryan L Roth

IDrugs· June 2005

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Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.
Feng Yan, Philip D Mosier, Richard B Westkaemper, Jeremy Stewart, Jordan K Zjawiony, Timothy A Vortherms

Biochemistry· June 2005

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Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1.
Matthew S Goldberg, Antonio Pisani, Marian Haburcak, Timothy A Vortherms, Tohru Kitada

Neuron· February 2005

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Using molecular tools to dissect the role of Galphas in sensitization of AC1.
Timothy A Vortherms, Chau H Nguyen, Catherine H Berlot, Val J Watts

Mol Pharmacol· December 2004

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Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation.
Timothy A Vortherms, Val J Watts

J Pharmacol Exp Ther· January 2004

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