Publications by authors named "Timothy Durham"

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Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease.
Eizo Marutani, Maria Miranda, Timothy J Durham, Sharon H Kim, Dreson L Russell

Nat Neurosci· September 2025

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LY3522348, A New Ketohexokinase Inhibitor: A First-in-Human Study in Healthy Adults.
Tsuyoshi Fukuda, Brian R Thompson, Bram Brouwers, Hui-Rong Qian, Wei Wang, Timothy B Durham

Diabetes Ther· July 2025

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Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood.
Rahul Gupta, Timothy J Durham, Grant Chau, Md Mesbah Uddin, Wenhan Lu

bioRxiv· May 2025

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Author Correction: Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy

Nature· June 2024

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Single-cell analysis reveals context-dependent, cell-level selection of mtDNA.
Anna V Kotrys, Timothy J Durham, Xiaoyan A Guo, Venkata R Vantaku, Sareh Parangi

Nature· May 2024

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Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock.
Robert S Rogers, Rohit Sharma, Hardik B Shah, Owen S Skinner, Xiaoyan A Guo, Timothy J Durham

Metabolomics· March 2024

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Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.
Timothy B Durham, Junliang Hao, Patrick Spinazze, Douglas R Stack, James L Toth

J Med Chem· December 2023

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Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy

Nature· August 2023

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Matrix prior for data transfer between single cell data types in latent Dirichlet allocation.
Alan Min, Timothy Durham, Louis Gevirtzman, William Stafford Noble

PLoS Comput Biol· May 2023

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Hypoxia extends lifespan and neurological function in a mouse model of aging.
Robert S Rogers, Hong Wang, Timothy J Durham, Jonathan A Stefely, Norah A Owiti

PLoS Biol· May 2023

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Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy

medRxiv· January 2023

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Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
Rongjun He, Jifeng Wang, Zhi-Hong Yu, Julie S Moyers, M Dodson Michael, Timothy B Durham

J Med Chem· October 2022

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Comprehensive characterization of tissue-specific chromatin accessibility in L2 nematodes.
Timothy J Durham, Riza M Daza, Louis Gevirtzman, Darren A Cusanovich, Olubusayo Bolonduro

Genome Res· October 2021

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Author Correction: Avocado: a multi-scale deep tensor factorization method learns a latent representation of the human epigenome.
Jacob Schreiber, Timothy Durham, Jeffrey Bilmes, William Stafford Noble

Genome Biol· September 2021

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MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
Sneha Rath, Rohit Sharma, Rahul Gupta, Tslil Ast, Connie Chan, Timothy J Durham

Nucleic Acids Res· January 2021

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Inferring Causal Gene Regulatory Networks from Coupled Single-Cell Expression Dynamics Using Scribe.
Xiaojie Qiu, Arman Rahimzamani, Li Wang, Bingcheng Ren, Qi Mao, Timothy Durham

Cell Syst· March 2020

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Avocado: a multi-scale deep tensor factorization method learns a latent representation of the human epigenome.
Jacob Schreiber, Timothy Durham, Jeffrey Bilmes, William Stafford Noble

Genome Biol· March 2020

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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Harold B Brooks, Timothy I Meier, Sandaruwan Geeganage, Kevin R Fales, Kenneth J Thrasher, Timothy B Durham

Sci Rep· October 2018

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Functional characterization of enhancer evolution in the primate lineage.
Jason C Klein, Aidan Keith, Vikram Agarwal, Timothy Durham, Jay Shendure

Genome Biol· July 2018

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PREDICTD PaRallel Epigenomics Data Imputation with Cloud-based Tensor Decomposition.
Timothy J Durham, Maxwell W Libbrecht, J Jeffry Howbert, Jeff Bilmes, William Stafford Noble

Nat Commun· April 2018

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The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of and Transcription Factors.
Michelle M Kudron, Alec Victorsen, Louis Gevirtzman, LaDeana W Hillier, William W Fisher, Timothy J Durham

Genetics· March 2018

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CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.
Kacey J Prentice, Stacy G Wendell, Ying Liu, Judith A Eversley, Sonia R Salvatore, Timothy B Durham

EBioMedicine· January 2018

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Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Kevin R Fales, F George Njoroge, Harold B Brooks, Stefan Thibodeaux, Alicia Torrado, Timothy B Durham

J Med Chem· December 2017

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Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
Ana B Bueno, Javier Agejas, Howard Broughton, Robert Dally, Timothy B Durham

J Med Chem· December 2017

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A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.
Timothy B Durham, Jothirajah Marimuthu, James L Toth, Chin Liu, Lisa Adams

J Med Chem· July 2017

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