Publications by authors named "Timothy Hoey"

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Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions.
J Alex Aycinena, Anley E Tefera, Isaac Perea-Gil, Duncan Holbrook-Smith, Kevin Williams, Timothy Hoey

JACC Basic Transl Sci· December 2025

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Reduced Expression of MTSS1 Increases Sarcomere Number and Improves Contractility in Select Forms of Monogenic DCM.
Hannah Kleppe, Anastasia Budan, Luke Zhang, Marie Majetic, Reva Shenwai, Timothy Hoey

JACC Basic Transl Sci· November 2025

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AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models.
Amara Greer-Short, Anna Greenwood, Elena C Leon, Tawny Neal Qureshi, Konor von Kraut, Timothy Hoey

Nat Commun· March 2025

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Author Correction: Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice.
Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Timothy Hoey

Nat Commun· October 2024

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AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy.
Iris Wu, Aliya Zeng, Amara Greer-Short, J Alex Aycinena, Anley E Tefera, Timothy Hoey

Commun Med (Lond)· March 2024

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Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice.
Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Timothy Hoey

Nat Commun· February 2024

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Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus.
Huanyu Zhou, Jin Yang, Chetan Srinath, Aliya Zeng, Iris Wu, Timothy Hoey

Circulation· October 2023

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Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.
Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M Kapoun, Timothy Hoey

PLoS One· July 2020

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The analogous and opposing roles of double-stranded RNA-binding proteins in bacterial resistance.
Gah-Hyun Lim, Shifeng Zhu, Kai Zhang, Timothy Hoey, Jean-Marc Deragon

J Exp Bot· March 2019

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COP1, a negative regulator of photomorphogenesis, positively regulates plant disease resistance via double-stranded RNA binding proteins.
Gah-Hyun Lim, Timothy Hoey, Shifeng Zhu, Marion Clavel, Keshun Yu

PLoS Pathog· March 2018

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RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations.
Marcus M Fischer, V Pete Yeung, Fiore Cattaruzza, Rajaa Hussein, Wan-Ching Yen, Timothy Hoey

Sci Rep· November 2017

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WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death.
Marcus M Fischer, Belinda Cancilla, V Pete Yeung, Fiore Cattaruzza, Cecile Chartier, Timothy Hoey

Sci Adv· June 2017

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Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.
Jing Shan Lim, Alvaro Ibaseta, Marcus M Fischer, Belinda Cancilla, Gilbert O'Young, Timothy Hoey

Nature· May 2017

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Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.
Cecile Chartier, Janak Raval, Fumiko Axelrod, Chris Bond, Jennifer Cain, Timothy Hoey

Cancer Res· February 2016

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Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.
Wan-Ching Yen, Marcus M Fischer, Fumiko Axelrod, Christopher Bond, Jennifer Cain, Timothy Hoey

Clin Cancer Res· May 2015

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DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice.
Sonia Minuzzo, Valentina Agnusdei, Irene Pusceddu, Marica Pinazza, Lidia Moserle, Timothy Hoey

Carcinogenesis· January 2015

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NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells.
Anna Pastò, Valentina Serafin, Giorgia Pilotto, Claudia Lago, Chiara Bellio, Timothy Hoey

Cancer Res· April 2014

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Canonical wnt signaling is required for pancreatic carcinogenesis.
Yaqing Zhang, John P Morris, Wei Yan, Heather K Schofield, Austin Gurney, Timothy Hoey

Cancer Res· August 2013

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Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells.
Wan-Ching Yen, Marcus M Fischer, Mark Hynes, Jingjiang Wu, Edward Kim, Timothy Hoey

Clin Cancer Res· October 2012

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Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.
Austin Gurney, Fumiko Axelrod, Christopher J Bond, Jennifer Cain, Cecile Chartier, Timothy Hoey

Proc Natl Acad Sci U S A· July 2012

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Anti-DLL4, a cancer therapeutic with multiple mechanisms of action.
Austin Gurney, Timothy Hoey

Vasc Cell· August 2011

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Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.
Marcus Fischer, Wan-Ching Yen, Ann M Kapoun, Min Wang, Gilbert O'Young, Timothy Hoey

Cancer Res· March 2011

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Drug resistance, epigenetics, and tumor cell heterogeneity.
Timothy Hoey

Sci Transl Med· April 2010

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.
Timothy Hoey, Wan-Ching Yen, Fumiko Axelrod, Jesspreet Basi, Lucas Donigian

Cell Stem Cell· August 2009

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Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo.
Edward Htun van der Horst, Lawrence Chinn, Min Wang, Timothy Velilla, Hoang Tran, Timothy C Hoey

Neoplasia· April 2009

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