Publications by authors named "Timothy J Miles"

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Target product profile and discovery and development path for novel cryptococcal disease treatments.
David B Meya, Manu De Rycker, Ian H Gilbert, William Hope, Justine Jelagat Odionyi, Timothy J Miles

J Infect· November 2025

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The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships.
Josepine Fernow, Marie Olliver, William Couet, Sophie Lagrange, Meindert H Lamers, Timothy J Miles

Nat Rev Drug Discov· January 2025

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Structure-Guided Design and Synthesis of a Pyridazinone Series of Proteasome Inhibitors.
Michael G Thomas, Kate McGonagle, Paul Rowland, David A Robinson, Peter G Dodd, Timothy J Miles

J Med Chem· August 2023

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Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Susan Wyllie, Michael Thomas, Stephen Patterson, Sabrinia Crouch, Manu De Rycker, Timothy J Miles

Nature· July 2023

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Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
Michael Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Timothy J Miles

J Med Chem· May 2021

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Identification of 6-amino-1-pyrazolo[3,4-]pyrimidines with efficacy against visceral leishmaniasis.
Michael G Thomas, Manu De Rycker, Myriam Ajakane, Sabrinia D Crouch, Lorna Campbell, Timothy J Miles

RSC Med Chem· October 2020

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Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent Antileishmanial Activity: Initial SAR and Assessment of Activity.
Michael G Thomas, Manu De Rycker, Richard J Wall, Daniel Spinks, Ola Epemolu, Timothy J Miles

J Med Chem· September 2020

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The Q Site of Cytochrome is a Promiscuous Drug Target in and .
Richard J Wall, Sandra Carvalho, Rachel Milne, Juan A Bueren-Calabuig, Sonia Moniz, Timothy J Miles

ACS Infect Dis· March 2020

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Setting Our Sights on Infectious Diseases.
Manu De Rycker, David Horn, Bree Aldridge, Richard K Amewu, Clifton E Barry, Timothy J Miles

ACS Infect Dis· January 2020

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-Wa Chung, Timothy J Miles

Proc Natl Acad Sci U S A· May 2019

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Optimisation of a key cross-coupling reaction towards the synthesis of a promising antileishmanial compound.
Raul F Velasco, César Guerrero, Gloria Fra, Alejandra Moure, Juan Miguel-Siles, Timothy J Miles

Tetrahedron Lett· May 2019

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Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
Michael G Thomas, Manu De Rycker, Myriam Ajakane, Sébastian Albrecht, Ana Isabel Álvarez-Pedraglio, Timothy J Miles

J Med Chem· February 2019

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Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.
Richard J Wall, Sonia Moniz, Michael G Thomas, Suzanne Norval, Eun-Jung Ko, Timothy J Miles

Antimicrob Agents Chemother· August 2018

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Susan Wyllie, Michael Thomas, Stephen Patterson, Sabrinia Crouch, Manu De Rycker, Timothy J Miles

Nature· August 2018

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Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
Stephen Brand, Eun Jung Ko, Elisabet Viayna, Stephen Thompson, Daniel Spinks, Timothy J Miles

J Med Chem· September 2017

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Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Timothy J Miles, Alan J Hennessy, Ben Bax, Gerald Brooks, Barry S Brown

Bioorg Med Chem Lett· May 2016

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Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.
Timothy J Miles, Alan J Hennessy, Ben Bax, Gerald Brooks, Barry S Brown

Bioorg Med Chem Lett· October 2013

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Asymmetric synthesis of the fully elaborated pyrrolidinone core of oxazolomycin A.
Timothy J Donohoe, Timothy J C O'Riordan, Manuel Peifer, Christopher R Jones, Timothy J Miles

Org Lett· November 2012

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Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.
Timothy J Miles, Christopher Barfoot, Gerald Brooks, Pamela Brown, Dongzhao Chen

Bioorg Med Chem Lett· December 2011

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Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.
Timothy J Miles, Jeffrey M Axten, Christopher Barfoot, Gerald Brooks, Pamela Brown

Bioorg Med Chem Lett· December 2011

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Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance.
Alexandre Wohlkonig, Pan F Chan, Andrew P Fosberry, Paul Homes, Jianzhong Huang, Timothy J Miles

Nat Struct Mol Biol· September 2010

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Organolithium-induced alkylative ring opening of aziridines: synthesis of unsaturated amino alcohols and ethers.
David M Hodgson, Bogdan Stefane, Timothy J Miles, Jason Witherington

J Org Chem· October 2006

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Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums.
David M Hodgson, Bogdan Stefane, Timothy J Miles, Jason Witherington

Chem Commun (Camb)· October 2004

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Enantioselective alkylative double ring opening of epoxides: synthesis of enantioenriched unsaturated diols and amino alcohols.
David M Hodgson, Christopher R Maxwell, Timothy J Miles, Edyta Paruch, Matthew A H Stent

Angew Chem Int Ed Engl· November 2002

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