Publications by authors named "Timothy M Clay"

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The Landscape of Early Clinical Gene Therapies outside of Oncology.
Laure Rittié, Takis Athanasopoulos, Miguel Calero-Garcia, Marie L Davies, David J Dow, Timothy M Clay

Mol Ther· October 2019

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Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.
Takuya Osada, Zachary C Hartman, Junping Wei, Gangjun Lei, Amy C Hobeika, Timothy M Clay

Breast Cancer Res· August 2018

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A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer.
Michael A Morse, Donna Niedzwiecki, John L Marshall, Christopher Garrett, David Z Chang, Timothy M Clay

Ann Surg· December 2013

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Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients.
Michael A Morse, Arvind Chaudhry, Elizabeth S Gabitzsch, Amy C Hobeika, Takuya Osada, Timothy M Clay

Cancer Immunol Immunother· August 2013

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Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
Nicholas C D'Amato, Julie H Ostrander, Michelle L Bowie, Christopher Sistrunk, Alexander Borowsky, Timothy M Clay

PLoS One· May 2013

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Cancer regression and neurological toxicity cases after anti-MAGE-A3 TCR gene therapy.
Vincent G Brichard, Jamila Louahed, Timothy M Clay

J Immunother· February 2013

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Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects.
Takuya Osada, Peter Berglund, Michael A Morse, Bolyn Hubby, Whitney Lewis, Timothy M Clay

Cancer Immunol Immunother· November 2012

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Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.
Xiu-Rong Ren, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu, Timothy M Clay

Breast Cancer Res· June 2012

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Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease.
Ping Zhang, Baodong Sun, Takuya Osada, Ramona Rodriguiz, Xiao Yi Yang, Timothy M Clay

Hum Gene Ther· May 2012

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Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibition [corrected].
Erika Hamilton, Kimberly Blackwell, Amy C Hobeika, Timothy M Clay, Gloria Broadwater

J Transl Med· February 2012

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Increasing vaccine potency through exosome antigen targeting.
Zachary C Hartman, Junping Wei, Oliver K Glass, Hongtao Guo, Gangjun Lei, Timothy M Clay

Vaccine· November 2011

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Immunologic monitoring of cellular immune responses in cancer vaccine therapy.
Theresa L Whiteside, James L Gulley, Timothy M Clay, Kwong Yok Tsang

J Biomed Biotechnol· October 2011

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New perspectives on zoledronic acid in breast cancer: potential augmentation of anticancer immune response.
Erika Hamilton, Timothy M Clay, Kimberly L Blackwell

Cancer Invest· October 2011

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Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.
Wenle Xia, Zuguo Liu, Rongrong Zong, Leihua Liu, Sumin Zhao, Timothy M Clay

Mol Cancer Ther· August 2011

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HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis.
Zachary C Hartman, Xiao-Yi Yang, Oliver Glass, Gangjun Lei, Takuya Osada, Timothy M Clay

Cancer Res· July 2011

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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
Takuya Osada, Minyong Chen, Xiao Yi Yang, Ivan Spasojevic, Jeffrey B Vandeusen, Timothy M Clay

Cancer Res· June 2011

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Depletion of human regulatory T cells.
Amy C Hobeika, Michael A Morse, Takuya Osada, Sharon Peplinski, H Kim Lyerly, Timothy M Clay

Methods Mol Biol· May 2011

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MHC class I-presented tumor antigens identified in ovarian cancer by immunoproteomic analysis are targets for T-cell responses against breast and ovarian cancer.
Michael A Morse, Angeles A Secord, Kimberly Blackwell, Amy C Hobeika, Gomathinayagam Sinnathamby, Timothy M Clay

Clin Cancer Res· May 2011

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Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines.
Timothy M Clay, Takuya Osada, Zachary C Hartman, Amy Hobeika, Gayathri Devi

Immunol Res· April 2011

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CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer.
Xinhui Wang, Takuya Osada, Yangyang Wang, Ling Yu, Koichi Sakakura, Timothy M Clay

J Natl Cancer Inst· October 2010

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An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.
Michael A Morse, Amy C Hobeika, Takuya Osada, Peter Berglund, Bolyn Hubby, Timothy M Clay

J Clin Invest· September 2010

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Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity.
Zachary C Hartman, Takuya Osada, Oliver Glass, Xiao Y Yang, Gang-Jun Lei, Timothy M Clay

Cancer Res· September 2010

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CpG oligodeoxynucleotides as TLR9 agonists: therapeutic applications in cancer.
Yanal M Murad, Timothy M Clay

BioDrugs· July 2010

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Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.
Michael A Morse, Junping Wei, Zachary Hartman, Wenle Xia, Xiu-Rong Ren, Timothy M Clay

Int J Cancer· June 2010

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An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity.
Zachary C Hartman, Junping Wei, Takuya Osada, Oliver Glass, Gangjun Lei, Timothy M Clay

Clin Cancer Res· March 2010

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