Publications by authors named "Timothy McDonald"

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Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease.
Rachel Nice, Simeng Lin, Neil Chanchlani, Claire Bewshea, Nicholas A Kennedy, Timothy J McDonald

J Appl Lab Med· November 2025

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Persisting plasma proinsulin levels in a cohort of 482 individuals with long-standing type 1 diabetes mellitus.
Douwe Frank de Wit, Coco Marjolein Fuhri Snethlage, Rana Minab, Elena Rampanelli, Pleun de Groen, Timothy James McDonald

Diabetes Obes Metab· October 2025

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Updating a Clinical Prediction Model for Identifying Monogenic Diabetes to Include Both Clinical Features and Biomarkers.
Julieanne Knupp, Pedro Cardoso, Katherine G Young, Timothy J McDonald, Kashyap A Patel

Diabetes Care· October 2025

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Non-autoimmune, insulin-deficient diabetes in children and young adults in Africa: evidence from the Young-Onset Diabetes in sub-Saharan Africa (YODA) cross-sectional study.
Jean Claude Katte, Steven Squires, Mesmin Y Dehayem, Priscilla A Balungi, Carolyn J Padoa, Timothy J McDonald

Lancet Diabetes Endocrinol· September 2025

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Glycated albumin and fructosamine do not improve accuracy of glycaemic control assessment in patients with conditions reported to affect HbA reliability.
Anxious J Niwaha, Priscilla A Balungi, Timothy J McDonald, Andrew T Hattersley, Beverley M Shields

Diabet Med· July 2025

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Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study.
Richard Howey, Jonathan Adam, Jerzy Adamski, Natalie N Atabaki, Søren Brunak, Timothy J McDonald

PLoS Genet· July 2025

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The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients-an IMI-DIRECT prospective study.
Liwei Lyu, Yong Fan, Josef Korbinian Vogt, Marc Clos-Garcia, Amelie Bonnefond, Timothy J McDonald

Genome Med· July 2025

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Triaging colorectal urgent referrals in the COVID-19 era using faecal immunochemical testing: a prospective UK real-world multicentre cohort study.
Gareth Walker, Supriya Balasubramanya, Joel Bowen, Nedal Debab, Robert Bethune, Timothy McDonald

BMJ Open Gastroenterol· July 2025

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A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study.
Natalie N Atabaki, Daniel E Coral, Hugo Pomares-Millan, Kieran Smith, Harry H Behjat, Timothy J McDonald

medRxiv· June 2025

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Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study.
Sapna Sharma, Qiuling Dong, Mark Haid, Jonathan Adam, Roberto Bizzotto, Timothy J McDonald

Diabetologia· December 2024

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Autoantibodies to Truncated GAD(96-585) Antigen Stratify Risk of Early Insulin Requirement in Adult-Onset Diabetes.
Sian L Grace, Kathleen M Gillespie, Claire L Williams, Vito Lampasona, Peter Achenbach, Timothy J McDonald

Diabetes· October 2024

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Associations between diabetes-related genetic risk scores and residual beta cell function in type 1 diabetes: the GUTDM1 study.
Coco M Fuhri Snethlage, Manon Balvers, Bart Ferwerda, Elena Rampanelli, Pleun de Groen, Timothy J McDonald

Diabetologia· September 2024

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The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study.
Rebeca Eriksen, Margaret C White, Adem Y Dawed, Isabel Garcia Perez, Joram M Posma, Timothy J McDonald

J Clin Endocrinol Metab· August 2024

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Utility and limitations of monitoring kidney transplants using capillary sampling.
Daniel J Whitbread, Rachel Nice, Sarah Benyon, Coralie Bingham, Richard A Oram, Timothy J McDonald

Clin Chem Lab Med· August 2024

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Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes.
Coco M Fuhri Snethlage, Timothy J McDonald, Richard D Oram, Pleun de Groen, Elena Rampanelli

Diabetes Care· July 2024

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The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes.
Guy S Taylor, Kieran Smith, Jadine Scragg, Timothy J McDonald, James A Shaw

Diabetologia· July 2024

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Impact of haemoglobin variants on the diagnostic sensitivity of glycated haemoglobin (HbA1c) assay methodologies in sub-Saharan Africa: a laboratory-based method validation study.
Priscilla Agatha Balungi, Anxious Jackson Niwaha, Rachel Nice, Lauren Rodgers, Nathan Mubiru, Timothy J McDonald

Pan Afr Med J· July 2024

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Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.
Neil Chanchlani, Simeng Lin, Claire Bewshea, Benjamin Hamilton, Amanda Thomas, Timothy J McDonald

Lancet Gastroenterol Hepatol· June 2024

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Comparison of Bayesian approaches for developing prediction models in rare disease: application to the identification of patients with Maturity-Onset Diabetes of the Young.
Pedro Cardoso, Timothy J McDonald, Kashyap A Patel, Ewan R Pearson, Andrew T Hattersley

BMC Med Res Methodol· June 2024

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Transdermal Blood Sampling for C-Peptide Is a Minimally Invasive, Reliable Alternative to Venous Sampling in Children and Adults With Type 1 Diabetes.
Rachel E J Besser, Anna E Long, Katharine R Owen, Rebecca Law, Jacqueline S Birks, Timothy J McDonald

Diabetes Care· February 2024

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Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes.
Pamela Bowman, Kashyap A Patel, Timothy J McDonald, Jens J Holst, Bolette Hartmann

J Diabetes Investig· December 2023

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Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
Andrew A Brown, Juan J Fernandez-Tajes, Mun-Gwan Hong, Caroline A Brorsson, Robert W Koivula, Timothy J McDonald

Nat Commun· August 2023

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Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Rosa Lundbye Allesøe, Agnete Troen Lundgaard, Ricardo Hernández Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Timothy McDonald

Nat Biotechnol· July 2023

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Pretreatment Vitamin D Concentrations Do Not Predict Therapeutic Outcome to Anti-TNF Therapies in Biologic-Naïve Patients With Active Luminal Crohn's Disease.
Neil Chanchlani, Simeng Lin, Rebecca Smith, Christopher Roberts, Rachel Nice, Timothy J McDonald

Crohns Colitis 360· July 2023

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Commentary on Abnormal Hb A1c Result from a Diabetic Patient Leads to Unexpected Diagnosis.
Timothy J McDonald

Clin Chem· July 2023

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