Publications by authors named "Timothy Perera"

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Quantification and clinical validation of the selective MET kinase inhibitor DO-2 and its metabolites DO-5 and M3 in human plasma.
Barend J Sikkema, Ron H J Mathijssen, Debbie G J Robbrecht, Timothy P S Perera, Stijn L W Koolen

J Pharm Biomed Anal· March 2024

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A Phase I Trial of the Dual MET Kinase/OCT-2 Inhibitor OMO-1 in Metastatic Solid Malignancies Including MET Exon 14 Mutated Lung Cancer.
Melinda A Pruis, Matthew G Krebs, Ruth Plummer, Filip De Vos, Eric Angevin, Timothy Perera

Oncologist· December 2023

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MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanised HGF knock-in mice.
Marie Fernandes, Brynna Hoggard, Philippe Jamme, Sonia Paget, Marie-José Truong, Timothy Perera

Mol Oncol· November 2023

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One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer.
Jonas Steenbrugge, Julie Bellemans, Niels Vander Elst, Kristel Demeyere, Josephine De Vliegher, Timothy Perera

Oncoimmunology· July 2022

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Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by Inhibition.
Concetta D'Ambrosio, Jessica Erriquez, Sonia Capellero, Simona Cignetto, Maria Alvaro, Timothy Perera

Int J Mol Sci· May 2022

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OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer.
Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek N Sanders, Timothy Perera

NPJ Breast Cancer· March 2021

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Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours.
Valentina Martin, Cristina Chiriaco, Chiara Modica, Anna Acquadro, Marco Cortese, Timothy Perera

Br J Cancer· March 2019

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Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor.
Timothy P S Perera, Eleonora Jovcheva, Laurence Mevellec, Jorge Vialard, Desiree De Lange

Mol Cancer Ther· June 2017

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Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors.
Alessia Mira, Virginia Morello, Maria Virtudes Céspedes, Timothy Perera, Paolo M Comoglio

Oncotarget· June 2017

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Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody.
Emanuela Pupo, Nadia Ducano, Barbara Lupo, Elisa Vigna, Daniele Avanzato, Timothy Perera

Cancer Res· September 2016

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C-met inhibition blocks bone metastasis development induced by renal cancer stem cells.
Lucia D'Amico, Dimas Belisario, Giorgia Migliardi, Cristina Grange, Benedetta Bussolati, Timothy Perera

Oncotarget· July 2016

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MET inhibition overcomes radiation resistance of glioblastoma stem-like cells.
Francesca De Bacco, Antonio D'Ambrosio, Elena Casanova, Francesca Orzan, Roberta Neggia, Timothy Perera

EMBO Mol Med· May 2016

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Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.
Consalvo Petti, Gabriele Picco, Maria Luisa Martelli, Elena Trisolini, Enrico Bucci, Timothy Perera

Oncotarget· January 2015

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Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs.
Selma Pennacchietti, Manuela Cazzanti, Andrea Bertotti, William M Rideout, May Han, Timothy Perera

Cancer Res· November 2014

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Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy.
Daniele Musiani, John David Konda, Simona Pavan, Erica Torchiaro, Francesco Sassi, Timothy Perera

FASEB J· September 2014

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CD74-NRG1 fusions in lung adenocarcinoma.
Lynnette Fernandez-Cuesta, Dennis Plenker, Hirotaka Osada, Ruping Sun, Roopika Menon, Timothy Perera

Cancer Discov· April 2014

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MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.
Paolo Luraghi, Gigliola Reato, Elia Cipriano, Francesco Sassi, Francesca Orzan, Timothy Perera

Cancer Res· March 2014

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Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer.
Alberto Bardelli, Simona Corso, Andrea Bertotti, Sebastijan Hobor, Emanuele Valtorta, Timothy Perera

Cancer Discov· June 2013

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A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.
Davide Torti, Francesco Sassi, Francesco Galimi, Stefania Gastaldi, Timothy Perera

Int J Cancer· March 2012

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Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations.
Francesco Galimi, Davide Torti, Francesco Sassi, Claudio Isella, Davide Corà, Timothy Perera

Clin Cancer Res· May 2011

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Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer.
Francesca De Bacco, Paolo Luraghi, Enzo Medico, Gigliola Reato, Flavia Girolami, Timothy Perera

J Natl Cancer Inst· April 2011

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Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn.
Timothy Me Scales, Pascal Derkinderen, Kit-Yi Leung, Helen L Byers, Malcolm A Ward, Timothy Perera

Mol Neurodegener· January 2011

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The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Igor Vivanco, Daniel Rohle, Matthias Versele, Akio Iwanami, Daisuke Kuga, Timothy Perera

Proc Natl Acad Sci U S A· April 2010

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Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.
C Hugh Reynolds, Claire J Garwood, Selina Wray, Caroline Price, Stuart Kellie, Timothy Perera

J Biol Chem· June 2008

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Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.
Pascal Derkinderen, Timothy M E Scales, Diane P Hanger, Kit-Yi Leung, Helen L Byers, Timothy Perera

J Neurosci· July 2005

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