Publications by authors named "Timothy S Luongo"

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Cardiac NAD depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics.
Khanh V Doan, Timothy S Luongo, Thato T Ts'olo, Won Dong Lee, David W Frederick

Nat Cardiovasc Res· October 2024

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MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure.
Joanne F Garbincius, Timothy S Luongo, Jonathan P Lambert, Adam S Mangold, Emma K Murray

bioRxiv· April 2023

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Enhanced NCLX-dependent mitochondrial Ca efflux attenuates pathological remodeling in heart failure.
Joanne F Garbincius, Timothy S Luongo, Pooja Jadiya, Alycia N Hildebrand, Devin W Kolmetzky

J Mol Cell Cardiol· June 2022

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Circadian REV-ERBs repress to activate NAMPT-dependent NAD biosynthesis and sustain cardiac function.
Pieterjan Dierickx, Kun Zhu, Bryce J Carpenter, Chunjie Jiang, Marit W Vermunt, Timothy S Luongo

Nat Cardiovasc Res· January 2022

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SLC25A51 is a mammalian mitochondrial NAD transporter.
Timothy S Luongo, Jared M Eller, Mu-Jie Lu, Marc Niere, Fabio Raith

Nature· December 2020

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The debate continues - What is the role of MCU and mitochondrial calcium uptake in the heart?
Joanne F Garbincius, Timothy S Luongo, John W Elrod

J Mol Cell Cardiol· June 2020

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mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia.
Lauren M Paolella, Sarmistha Mukherjee, Cassie M Tran, Bruna Bellaver, Mindy Hugo, Timothy S Luongo

Mol Metab· February 2020

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MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.
Jonathan P Lambert, Timothy S Luongo, Dhanendra Tomar, Pooja Jadiya, Erhe Gao

Circulation· November 2019

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Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.
Alyssa A Lombardi, Andrew A Gibb, Ehtesham Arif, Devin W Kolmetzky, Dhanendra Tomar, Timothy S Luongo

Nat Commun· October 2019

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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Pooja Jadiya, Devin W Kolmetzky, Dhanendra Tomar, Antonio Di Meco, Alyssa A Lombardi, Timothy S Luongo

Nat Commun· August 2019

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The mitochondrial Na/Ca exchanger is essential for Ca homeostasis and viability.
Timothy S Luongo, Jonathan P Lambert, Polina Gross, Mary Nwokedi, Alyssa A Lombardi

Nature· May 2017

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Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy.
Benjamin P Woodall, Meryl C Woodall, Timothy S Luongo, Laurel A Grisanti, Douglas G Tilley

J Biol Chem· October 2016

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MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.
Dhanendra Tomar, Zhiwei Dong, Santhanam Shanmughapriya, Diana A Koch, Toby Thomas, Timothy S Luongo

Cell Rep· May 2016

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The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.
Timothy S Luongo, Jonathan P Lambert, Ancai Yuan, Xueqian Zhang, Polina Gross

Cell Rep· July 2015

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Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Tongqing Zhou, Rebecca M Lynch, Lei Chen, Priyamvada Acharya, Xueling Wu, Timothy S Luongo

Cell· June 2015

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Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.
Priyamvada Acharya, William D Tolbert, Neelakshi Gohain, Xueji Wu, Lei Yu, Timothy S Luongo

J Virol· November 2014

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Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites.
Priyamvada Acharya, Timothy S Luongo, Ivelin S Georgiev, Julie Matz, Stephen D Schmidt

J Virol· September 2013

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Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1.
Priyamvada Acharya, Timothy S Luongo, Mark K Louder, Krisha McKee, Yongping Yang

Structure· June 2013

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Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry.
Priyamvada Acharya, Cajetan Dogo-Isonagie, Judith M LaLonde, Son N Lam, George J Leslie, Timothy S Luongo

ACS Chem Biol· October 2011

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