Publications by authors named "Tod Harper"

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Use of a Transgenic Human PNPLA3 Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics.
Ben Brooks, Artem Shkumatov, Jackson Kalanzi, Kim Henderson Park, Julie M Lade, Tod A Harper

Nucleic Acid Ther· December 2025

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Opportunities for More Tailored Approaches to Genotoxicity Testing and Carcinogenicity Strategy for Oligonucleotide Therapeutics: Outcome of an Industry Survey.
Joel D Parry, Tod A Harper, Patrik Andersson, Joanne M Elloway, Natalie S Holman

Nucleic Acid Ther· February 2025

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Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations.
Patrik Andersson, Sebastien A Burel, Heather Estrella, Jeffrey Foy, Peter H Hagedorn, Tod A Harper

Nucleic Acid Ther· February 2025

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Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low-Risk Modalities?
Yusheng Qu, Kim A Henderson, Tod A Harper, Hugo M Vargas

Clin Pharmacol Ther· July 2024

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Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.
Francesco Marchetti, Renato Cardoso, Connie L Chen, George R Douglas, Joanne Elloway, Tod Harper

Mutat Res Rev Mutat Res· December 2023

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Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing.
Francesco Marchetti, Renato Cardoso, Connie L Chen, George R Douglas, Joanne Elloway, Tod Harper

Nat Rev Drug Discov· March 2023

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Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys.
Tod Harper, Amy Sharma, Sarav Kaliyaperumal, Flordeliza Fajardo, Katie Hsu

Toxicol Sci· August 2022

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Nonclinical genotoxicity and carcinogenicity profile of apremilast, an oral selective inhibitor of PDE4.
Teresa Wegesser, Aldo Coppi, Tod Harper, Maria Paris, Sheroy Minocherhomji

Regul Toxicol Pharmacol· October 2021

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Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse.
Lisbeth K Siddens, Kristi L Bunde, Tod A Harper, Tammie J McQuistan, Christiane V Löhr

Toxicol Appl Pharmacol· September 2015

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Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder.
Richard De La Garza, Marcy J Bubar, Crystal L Carbone, F Gerard Moeller, Thomas F Newton, Tod A Harper

Prog Neuropsychopharmacol Biol Psychiatry· June 2015

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Aryl hydrocarbon receptor-dependent stanniocalcin 2 induction by cinnabarinic acid provides cytoprotection against endoplasmic reticulum and oxidative stress.
Aditya D Joshi, Dwayne E Carter, Tod A Harper, Cornelis J Elferink

J Pharmacol Exp Ther· April 2015

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Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS.
Tod A Harper, Jeff Morré, Fredine T Lauer, Tammie J McQuistan, Jessica M Hummel

Mutat Res Genet Toxicol Environ Mutagen· April 2015

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Identification of stanniocalcin 2 as a novel aryl hydrocarbon receptor target gene.
Tod A Harper, Aditya D Joshi, Cornelis J Elferink

J Pharmacol Exp Ther· March 2013

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