Publications by authors named "Todd D Gould"

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Ketamine to enhance methadone treatment retention in patients with opioid use disorder and co-morbid depression.
Peter Manza, Annabelle M Belcher, Heather Fitzsimons, Max Spaderna, Aaron D Greenblatt, Todd D Gould

Am J Drug Alcohol Abuse· November 2025

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Synaptic priming: A framework for pharmacotherapy in depression.
Kyle A Brown, Musa I Ajibola, Gustavo C Medeiros, Todd D Gould

Neuron· November 2025

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Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain.
Polymnia Georgiou, Abagail F Postle, Ta-Chung M Mou, Liam E Potter, Xiaoxian An, Todd D Gould

Mol Psychiatry· October 2025

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Intermittent Ketamine and Neuromodulation Treatment Evoke Synergistic Antidepressant-Relevant Action.
Kyle A Brown, Todd D Gould

Biol Psychiatry· October 2025

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Bioactive ketamine metabolite exerts in vivo neuroplastogenic effects to improve hippocampal function in a treatment-resistant depression model.
Lace M Riggs, Sage Aronson, Ta-Chung M Mou, Edna F R Pereira, Scott M Thompson, Todd D Gould

Cell Rep· June 2025

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Relative to females, male rats are more willing to forego obtaining sucrose reward in order to prevent harm to their cage mate.
Evan M Hess, Marco Venniro, Todd D Gould

Psychopharmacology (Berl)· May 2025

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Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity.
Kyle A Brown, Musa I Ajibola, Todd D Gould

Neuropsychopharmacology· May 2025

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Associations between hypothalamic-pituitary-adrenal (HPA) axis hormone levels, major depression features and antidepressant effects of ketamine.
Polymnia Georgiou, Cristan A Farmer, Gustavo C Medeiros, Peixiong Yuan, Jenessa Johnston, Todd D Gould

J Affect Disord· March 2025

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Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.
Thi Mai Loan Nguyen, Jean-Philippe Guilloux, Céline Defaix, Indira Mendez-David, Isabelle Etting, Todd D Gould

Neuropharmacology· November 2024

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A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)-Hydroxynorketamine in Healthy Volunteers.
Shruti M Raja, Jeffrey T Guptill, Michelle Mack, Marni Peterson, Stephen Byard, Todd D Gould

Clin Pharmacol Ther· November 2024

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Pathophysiologic abnormalities in transgenic mice carrying the Alzheimer disease PSEN1 Δ440 mutation.
Peyton E Fuller, Victoria L Collis, Pallavi Sharma, Angelina M Burkett, Shaoteng Wang, Todd D Gould

Hum Mol Genet· November 2024

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Personalized use of ketamine and esketamine for treatment-resistant depression.
Gustavo C Medeiros, Isabella Demo, Fernando S Goes, Carlos A Zarate, Todd D Gould

Transl Psychiatry· November 2024

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Rapid Hippocampal Synaptic Potentiation Induced by Ketamine Metabolite ( , )-Hydroxynorketamine Persistently Primes Synaptic Plasticity.
Kyle A Brown, Musa I Ajibola, Todd D Gould

bioRxiv· October 2024

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Entactogen Effects of Ketamine: A Reverse-Translational Study.
Evan M Hess, Dede K Greenstein, Olivia L Hutchinson, Carlos A Zarate, Todd D Gould

Am J Psychiatry· September 2024

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Targeting metaplasticity mechanisms to promote sustained antidepressant actions.
Kyle A Brown, Todd D Gould

Mol Psychiatry· April 2024

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Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient.
Kyle A Brown, Todd D Gould

Neuropsychopharmacology· January 2024

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cAMP-dependent protein kinase signaling is required for ()-hydroxynorketamine to potentiate hippocampal glutamatergic transmission.
Lace M Riggs, Edna F R Pereira, Scott M Thompson, Todd D Gould

J Neurophysiol· January 2024

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Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion.
Ruin Moaddel, Cristan A Farmer, Mani Yavi, Bashkim Kadriu, Min Zhu, Todd D Gould

iScience· December 2023

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Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies.
Gustavo C Medeiros, Malcolm Matheson, Isabella Demo, Matthew J Reid, Sharaya Matheson, Todd D Gould

Lancet Psychiatry· October 2023

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Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters.
Kyle A Brown, Panos Zanos, Chris F Powels, Connor J Fix, Michael Michaelides, Todd D Gould

Neuropharmacology· March 2023

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κ-Opioid Receptor Plasma Levels Are Associated With Sex and Diagnosis of Major Depressive Disorder But Not Response to Ketamine.
Brandi Quintanilla, Gustavo C Medeiros, Dede Greenstein, Peixiong Yuan, Jenessa N Johnston, Todd D Gould

J Clin Psychopharmacol· March 2023

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NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine.
Panos Zanos, Kyle A Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A Zarate, Todd D Gould

J Neurosci· February 2023

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Possible psychedelic therapeutic mechanism.
Evan M Hess, Todd D Gould

Science· February 2023

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Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor.
Polymnia Georgiou, Panos Zanos, Ta-Chung M Mou, Xiaoxian An, Danielle M Gerhard, Todd D Gould

Nat Neurosci· September 2022

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Inconvenient truths and the usefulness of identifying unknown unknowns.
Todd D Gould, Polymnia Georgiou

Nat Neurosci· September 2022

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