Publications by authors named "Todd Shearer"

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Kinetics of Nirogacestat-Mediated Increases in B-cell Maturation Antigen on Plasma Cells Inform Therapeutic Combinations in Multiple Myeloma.
Todd Shearer, Melissa Comstock, Rex L Williams, Mark C Johnson, Ewa Cendrowicz

Cancer Res Commun· December 2024

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Onapristone Extended Release: Safety Evaluation from Phase I-II Studies with an Emphasis on Hepatotoxicity.
James H Lewis, Paul H Cottu, Martin Lehr, Evan Dick, Todd Shearer

Drug Saf· October 2020

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An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Daniel J Price, David H Drewry, Lee T Schaller, Brian D Thompson, Paul R Reid, Todd W Shearer

Bioorg Med Chem Lett· June 2018

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Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.
Mahalakshmi Shankaran, Todd W Shearer, Stephen A Stimpson, Scott M Turner, Chelsea King

Am J Physiol Endocrinol Metab· March 2016

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Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.
J David Becherer, Eric E Boros, Tiffany Y Carpenter, David J Cowan, David N Deaton, Barry G Shearer, Todd W Shearer

J Med Chem· September 2015

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Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.
Curt D Haffner, J David Becherer, Eric E Boros, Rodolfo Cadilla, Tiffany Carpenter, Barry G Shearer, Todd Shearer

J Med Chem· April 2015

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Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D-creatine dilution method.
Stephen A Stimpson, Michael S Leonard, Lisa G Clifton, James C Poole, Scott M Turner, Todd W Shearer

J Cachexia Sarcopenia Muscle· June 2013

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Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
Hongfeng Deng, Heather O'Keefe, Christopher P Davie, Kenneth E Lind, Raksha A Acharya, Todd W Shearer

J Med Chem· August 2012

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Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats.
Stephen A Stimpson, Scott M Turner, Lisa G Clifton, James C Poole, Hussein A Mohammed, Todd W Shearer

J Appl Physiol (1985)· June 2012

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Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist.
Diane M Ignar, Aaron S Goetz, Kimberly Nichols Noble, Luz Helena Carballo, Andrea E Stroup, Todd W Shearer

J Pharmacol Exp Ther· October 2011

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Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
Barry G Shearer, Robert W Wiethe, Adam Ashe, Andrew N Billin, James M Way, Todd W Shearer

J Med Chem· February 2010

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Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.
Karen A Evans, Brian W Budzik, Sean A Ross, David D Wisnoski, Jian Jin, Todd W Shearer

J Med Chem· December 2009

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Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.
Damaris S Diaz, Michael P Kozar, Kirsten S Smith, Constance O Asher, Jason C Sousa, Todd W Shearer

Drug Metab Dispos· February 2008

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Pharmacokinetics, safety, and hydrolysis of oral pyrroloquinazolinediamines administered in single and multiple doses in rats.
Qigui Li, Michael P Kozar, Todd W Shearer, Lisa H Xie, Ai J Lin

Antimicrob Agents Chemother· August 2007

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In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.
Todd W Shearer, Michael P Kozar, Michael T O'Neil, Philip L Smith, Guy A Schiehser

J Med Chem· April 2005

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The role of in vitro ADME assays in antimalarial drug discovery and development.
Todd W Shearer, Kirsten S Smith, Damaris Diaz, Constance Asher, Julio Ramirez

Comb Chem High Throughput Screen· February 2005

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Bradykinin enhancement of PGE2 signalling in bovine trabecular meshwork cells.
Jerry G Webb, Todd W Shearer, Phillip W Yates, Yurii V Mukhin, Craig E Crosson

Exp Eye Res· March 2003

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Adenosine A1 receptor modulation of MMP-2 secretion by trabecular meshwork cells.
Todd W Shearer, Craig E Crosson

Invest Ophthalmol Vis Sci· September 2002

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