Publications by authors named "Tom Ceska"

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Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Adrian Hall, Jan Abendroth, Madison J Bolejack, Tom Ceska, Sylvie Dell'Aiera

ACS Med Chem Lett· July 2022

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Author Correction: Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis.
Anna J Higgins, Alex J Flynn, Anaïs Marconnet, Laura J Musgrove, Vincent L G Postis, Tom Ceska

Commun Biol· January 2022

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Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis.
Anna J Higgins, Alex J Flynn, Anaïs Marconnet, Laura J Musgrove, Vincent L G Postis, Tom Ceska

Commun Biol· November 2021

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Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist.
Bingfa Sun, Dan Feng, Matthew Ling-Hon Chu, Inbar Fish, Silvia Lovera, Tom Ceska

Nat Commun· June 2021

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Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Tom Ceska

Nat Commun· January 2021

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A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF.
Daniel J Lightwood, Rebecca J Munro, John Porter, David McMillan, Bruce Carrington, Tom Ceska

Nat Commun· January 2021

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Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Alkistis N Mitropoulou, Tom Ceska, James T Heads, Andrew J Beavil, Alistair J Henry

Acta Crystallogr F Struct Biol Commun· March 2020

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Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
James O'Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Tom Ceska

Nat Commun· December 2019

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Cryo-EM in drug discovery.
Tom Ceska, Chun-Wa Chung, Rob Cooke, Chris Phillips, Pamela A Williams

Biochem Soc Trans· February 2019

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Correction: Cryo-EM in drug discovery.
Tom Ceska, Chun-Wa Chung, Rob Cooke, Chris Phillips, Pamela A Williams

Biochem Soc Trans· February 2019

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Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
James Reuberson, Helen Horsley, Richard J Franklin, Daniel Ford, Judi Neuss, Tom Ceska

J Med Chem· August 2018

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Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.
Anna M Davies, Elizabeth G Allan, Anthony H Keeble, Jean Delgado, Benjamin P Cossins, Tom Ceska

J Biol Chem· June 2017

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Crystal structure of the adenosine A receptor bound to an antagonist reveals a potential allosteric pocket.
Bingfa Sun, Priti Bachhawat, Matthew Ling-Hon Chu, Martyn Wood, Tom Ceska

Proc Natl Acad Sci U S A· February 2017

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Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping.
Xiaofeng Liu, Richard D Taylor, Laura Griffin, Shu-Fen Coker, Ralph Adams, Tom Ceska

Sci Rep· January 2017

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Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life.
Ralph Adams, Laura Griffin, Joanne E Compson, Mark Jairaj, Terry Baker, Tom Ceska

MAbs· October 2016

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Direct observation of DNA threading in flap endonuclease complexes.
Faizah A AlMalki, Claudia S Flemming, Jing Zhang, Min Feng, Svetlana E Sedelnikova, Tom Ceska

Nat Struct Mol Biol· July 2016

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GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.
Alexander Heifetz, Gebhard F X Schertler, Roland Seifert, Christopher G Tate, Patrick M Sexton, Tom Ceska

Naunyn Schmiedebergs Arch Pharmacol· August 2015

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Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex.
Eric Jnoff, Claudia Albrecht, John J Barker, Oliver Barker, Edward Beaumont, Tom Ceska

ChemMedChem· April 2014

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Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
Roger M Benoit, Daniel Frey, Manuel Hilbert, Josta T Kevenaar, Mara M Wieser, Tom Ceska

Nature· January 2014

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Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.
Benjamin Perry, Rikki Alexander, Gavin Bennett, George Buckley, Tom Ceska

Bioorg Med Chem Lett· August 2008

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Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
Mahbub Alam, Rebekah E Beevers, Tom Ceska, Richard J Davenport, Karen M Dickson

Bioorg Med Chem Lett· June 2007

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