Publications by authors named "Trevor Perrior"

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Selective Aurora A-TPX2 Interaction Inhibitors Have Efficacy as Targeted Antimitotic Agents.
Simon R Stockwell, Duncan E Scott, Gerhard Fischer, Estrella Guarino, Timothy P C Rooney, Trevor R Perrior

J Med Chem· September 2024

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Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.
Jihui Zhang, Jie Chen, Jonathan P Richardson, Nicola-Jane Francis-Newton, Pei F Lai, Trevor R Perrior

ACS Pharmacol Transl Sci· September 2022

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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Duncan E Scott, Nicola J Francis-Newton, May E Marsh, Anthony G Coyne, Gerhard Fischer, Trevor Perrior

Cell Chem Biol· June 2021

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Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?
Maaike Te Lintel Hekkert, Gary Newton, Kathryn Chapman, Rehan Aqil, Robert Downham, Trevor Perrior

Basic Res Cardiol· May 2021

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IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.
Matthew Carr, Sami Mamand, Kathryn L Chapman, Trevor Perrior, Simon D Wagner

J Cell Mol Med· October 2020

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Releasing the technical 'shackles' on GPCR drug discovery: opportunities enabled by detergent-free polymer lipid particle (PoLiPa) purification.
J Daniel Hothersall, Andrew Y Jones, Tim R Dafforn, Trevor Perrior, Kathryn L Chapman

Drug Discov Today· August 2020

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Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4.
Pelin A Golforoush, Priyanka Narasimhan, Patricia P Chaves-Guerrero, Elsa Lawrence, Gary Newton, Trevor Perrior

Sci Rep· July 2020

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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Lorna R Fiedler, Kathryn Chapman, Min Xie, Evie Maifoshie, Micaela Jenkins, Trevor Perrior

Cell Stem Cell· March 2020

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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Lorna R Fiedler, Kathryn Chapman, Min Xie, Evie Maifoshie, Micaela Jenkins, Trevor Perrior

Cell Stem Cell· April 2019

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Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.
Jihui Zhang, Jie Chen, Jie Zuo, Gary K Newton, Mark R Stewart, Trevor R Perrior

Int J Mol Sci· October 2018

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Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design.
Jihui Zhang, Jie Chen, Gary K Newton, Trevor R Perrior, Clive Robinson

Mol Pharmacol· September 2018

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Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
Scott P Webster, Andrew McBride, Margaret Binnie, Karen Sooy, Jonathan R Seckl, Trevor R Perrior

Br J Pharmacol· March 2017

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Discovery to Development: Insecticides for Malaria Vector Control.
James A Turner, Colin N E Ruscoe, Trevor R Perrior

Chimia (Aarau)· October 2016

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The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Gary K Newton, Trevor R Perrior, Kerry Jenkins, Meriel R Major, Rebekah E Key

J Med Chem· November 2014

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Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors.
Elizabeth H Donahue, Lisa F Dawson, Esmeralda Valiente, Stuart Firth-Clark, Meriel R Major, Trevor R Perrior

BMC Microbiol· August 2014

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Nonhuman targets in allergic lung conditions.
Clive Robinson, Jihui Zhang, Gary K Newton, Trevor R Perrior

Future Med Chem· February 2013

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Future inhaled drugs by virtual innovation: allergen delivery inhibitors.
Clive Robinson, Jihui Zhang, David R Garrod, Gary K Newton, Kerry Jenkins, Trevor R Perrior

Future Med Chem· October 2011

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[(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.
David Scapens, Harry Adams, Tony R Johnson, Brian E Mann, Philip Sawle, Trevor Perrior

Dalton Trans· November 2007

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