Publications by authors named "Robert Downham"

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Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?
Maaike Te Lintel Hekkert, Gary Newton, Kathryn Chapman, Rehan Aqil, Robert Downham

Basic Res Cardiol· May 2021

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Correction to "Total Synthesis of (-)-Sarain A".
Michael H Becker, Peter Chua, Robert Downham, Christopher J Douglas, Neil K Garg

J Am Chem Soc· April 2018

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1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.
Saleh Ahmed, Andrew Ayscough, Greg R Barker, Hannah E Canning, Richard Davenport, Robert Downham

J Med Chem· July 2017

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Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Andrew J Woodhead, Hayley Angove, Maria G Carr, Gianni Chessari, Miles Congreve, Robert Downham

J Med Chem· August 2010

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Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
Christopher W Murray, Maria G Carr, Owen Callaghan, Gianni Chessari, Miles Congreve, Robert Downham

J Med Chem· August 2010

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Total synthesis of (+)-sarain A.
Michael H Becker, Peter Chua, Robert Downham, Christopher J Douglas, Neil K Garg

J Am Chem Soc· October 2007

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Identification of inhibitors of protein kinase B using fragment-based lead discovery.
Gordon Saxty, Steven J Woodhead, Valerio Berdini, Thomas G Davies, Marcel L Verdonk, Robert Downham

J Med Chem· May 2007

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Structure-activity studies on prolactin-releasing peptide (PrRP). Analogues of PrRP-(19-31)-peptide.
Robert G Boyle, Robert Downham, Tanmoy Ganguly, John Humphries, Jeff Smith

J Pept Sci· March 2005

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