Publications by authors named "Vincent Leveque"

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Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial.
Juanita Lopez, Thomas Powles, Fadi Braiteh, Lillian L Siu, Patricia LoRusso, Vincent J P Leveque

Nat Med· January 2025

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Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).
Marcin Kowanetz, Wei Zou, Scott N Gettinger, Hartmut Koeppen, Mark Kockx, Vincent Leveque

Proc Natl Acad Sci U S A· October 2018

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High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing.
Yinghui Guan, Oleg Mayba, Thomas Sandmann, Shan Lu, Younjeong Choi, Vincent Leveque

J Mol Diagn· November 2017

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Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma.
Jeffrey J Wallin, Johanna C Bendell, Roel Funke, Mario Sznol, Konstanty Korski, Vincent Leveque

Nat Commun· August 2016

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Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer.
Nam-Joon Cho, Edward A Pham, Rachel J Hagey, Vincent J Lévêque, Han Ma

ACS Cent Sci· July 2016

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Determination of neuraminidase kinetic constants using whole influenza virus preparations and correction for spectroscopic interference by a fluorogenic substrate.
Bindumadhav M Marathe, Vincent Lévêque, Klaus Klumpp, Robert G Webster, Elena A Govorkova

PLoS One· April 2014

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Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
Francisco X Talamas, Sarah C Abbot, Shalini Anand, Ken A Brameld, David S Carter, Vincent Leveque

J Med Chem· March 2014

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Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
Ryan C Schoenfeld, David L Bourdet, Ken A Brameld, Elbert Chin, Javier de Vicente, Vincent Leveque

J Med Chem· October 2013

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De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.
Francisco X Talamas, Gloria Ao-Ieong, Ken A Brameld, Elbert Chin, Javier de Vicente, Vincent Leveque

J Med Chem· April 2013

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NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.
Zhinan Jin, Vincent Leveque, Han Ma, Kenneth A Johnson, Klaus Klumpp

Proc Natl Acad Sci U S A· January 2013

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Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex.
Zhinan Jin, Vincent Leveque, Han Ma, Kenneth A Johnson, Klaus Klumpp

J Biol Chem· March 2012

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The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.
Choongho Lee, Han Ma, Julie Qi Hang, Vincent Leveque, Ella H Sklan

Virology· May 2011

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Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Hanbiao Yang, Robert T Hendricks, Nidhi Arora, Dov Nitzan, Calvin Yee, Vincent J P Leveque

Bioorg Med Chem Lett· August 2010

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Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Javier de Vicente, Robert T Hendricks, David B Smith, Jay B Fell, John Fischer, Vincent J P Leveque

Bioorg Med Chem Lett· October 2009

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Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Javier de Vicente, Robert T Hendricks, David B Smith, Jay B Fell, John Fischer, Vincent J P Leveque

Bioorg Med Chem Lett· October 2009

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Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
Robert T Hendricks, Jay B Fell, James F Blake, John P Fischer, John E Robinson, Vincent J P Leveque

Bioorg Med Chem Lett· July 2009

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Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
Javier de Vicente, Robert T Hendricks, David B Smith, Jay B Fell, John Fischer, Vincent Leveque

Bioorg Med Chem Lett· July 2009

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Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.
Julie Qi Hang, Yanli Yang, Seth F Harris, Vincent Leveque, Hannah J Whittington

J Biol Chem· June 2009

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The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
David B Smith, Genadiy Kalayanov, Christian Sund, Anna Winqvist, Tatiana Maltseva, Vincent J-P Leveque

J Med Chem· May 2009

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The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
David B Smith, Genadiy Kalayanov, Christian Sund, Anna Winqvist, Pedro Pinho, Vincent Leveque

J Med Chem· January 2009

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3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase.
Robert T Hendricks, Stacey R Spencer, James F Blake, Jay B Fell, John P Fischer, Vincent J P Leveque

Bioorg Med Chem Lett· January 2009

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Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479.
Samir Ali, Vincent Leveque, Sophie Le Pogam, Han Ma, Friederike Philipp

Antimicrob Agents Chemother· December 2008

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Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.
Stephen S Antonysamy, Brandon Aubol, Jeff Blaney, Michelle F Browner, Anthony M Giannetti, Vincent Leveque

Bioorg Med Chem Lett· May 2008

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2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.
Klaus Klumpp, Genadiy Kalayanov, Han Ma, Sophie Le Pogam, Vincent Leveque

J Biol Chem· January 2008

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First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
Plinio Perrone, Felice Daverio, Rocco Valente, Sonal Rajyaguru, Joseph A Martin

J Med Chem· November 2007

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