Publications by authors named "Vincent Mutel"

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Large Language Models, scientific knowledge and factuality: A framework to streamline human expert evaluation.
Magdalena Wysocka, Oskar Wysocki, Maxime Delmas, Vincent Mutel, André Freitas

J Biomed Inform· October 2024

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Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease.
Mark P Epping-Jordan, Françoise Girard, Anne-Sophie Bessis, Vincent Mutel, Christelle Boléa

Cells· March 2023

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The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABA receptor with a potential for treatment of anxiety, pain and spasticity.
Mikhail Kalinichev, Françoise Girard, Hasnaà Haddouk, Mélanie Rouillier, Eric Riguet, Vincent Mutel

Neuropharmacology· March 2017

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The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Erwan Bezard, Elsa Y Pioli, Qin Li, Françoise Girard, Vincent Mutel

Mov Disord· July 2014

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Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor.
James A Dias, Brice Campo, Barbara A Weaver, Julie Watts, Kerri Kluetzman, Vincent Mutel

Biol Reprod· January 2014

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ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization.
Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Vincent Mutel

J Pharmacol Exp Ther· March 2013

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Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation.
Dominik Schelshorn, Fanny Joly, Sophie Mutel, Cornelia Hampe, Billy Breton, Vincent Mutel

Mol Pharmacol· March 2012

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mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents.
Jean-Philippe Rocher, Béatrice Bonnet, Christelle Boléa, Robert Lütjens, Emmanuel Le Poul, Vincent Mutel

Curr Top Med Chem· September 2011

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A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor.
James A Dias, Béatrice Bonnet, Barbara A Weaver, Julie Watts, Kerri Kluetzman, Vincent Mutel

Mol Cell Endocrinol· February 2011

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Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice.
Grayson Richards, Jürg Messer, Richard L M Faull, Heinz Stadler, Jürgen Wichmann, Vincent Mutel

Brain Res· December 2010

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Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers.
Eric Vieira, Jörg Huwyler, Synèse Jolidon, Frédéric Knoflach, Vincent Mutel

Bioorg Med Chem Lett· March 2009

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Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.
Thomas J Woltering, Jürgen Wichmann, Erwin Goetschi, Geo Adam, James N C Kew, Vincent Mutel

Bioorg Med Chem Lett· April 2008

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Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-HYDIA.
Thomas J Woltering, Geo Adam, Philipp Huguenin, Jürgen Wichmann, Sabine Kolczewski, Vincent Mutel

ChemMedChem· February 2008

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.
Thomas J Woltering, Geo Adam, Jürgen Wichmann, Erwin Goetschi, James N C Kew, Vincent Mutel

Bioorg Med Chem Lett· February 2008

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.
Thomas J Woltering, Geo Adam, Alexander Alanine, Jürgen Wichmann, Frédéric Knoflach, Vincent Mutel

Bioorg Med Chem Lett· December 2007

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The pros of not being competitive.
Vincent Mutel, Bernhard Bettler

Curr Neuropharmacol· September 2007

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Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.
Georg Jaeschke, Richard Porter, Bernd Büttelmann, Simona M Ceccarelli, Wolfgang Guba, Vincent Mutel

Bioorg Med Chem Lett· March 2007

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Cellular prion protein signaling in serotonergic neuronal cells.
Sophie Mouillet-Richard, Benoît Schneider, Elodie Pradines, Mathéa Pietri, Myriam Ermonval, Vincent Mutel

Ann N Y Acad Sci· January 2007

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Control of bioamine metabolism by 5-HT2B and alpha 1D autoreceptors through reactive oxygen species and tumor necrosis factor-alpha signaling in neuronal cells.
Benoit Schneider, Mathéa Pietri, Sophie Mouillet-Richard, Myriam Ermonval, Vincent Mutel

Ann N Y Acad Sci· December 2006

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Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
Richard H P Porter, Georg Jaeschke, Will Spooren, Theresa M Ballard, Bernd Büttelmann, Vincent Mutel

J Pharmacol Exp Ther· November 2005

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9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.
Eric Vieira, Jörg Huwyler, Synèse Jolidon, Frédéric Knoflach, Vincent Mutel

Bioorg Med Chem Lett· October 2005

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Opposite effects of Zn on the in vitro binding of [3H]LY354740 to recombinant and native metabotropic glutamate 2 and 3 receptors.
Pari Malherbe, J Grayson Richards, Clemens Broger, Marie-Thérèse Zenner, Jürg Messer, Vincent Mutel

J Neurochem· July 2005

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Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.
Mathéa Pietri, Benoît Schneider, Sophie Mouillet-Richard, Myriam Ermonval, Vincent Mutel

FASEB J· July 2005

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Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPgammas binding.
Grayson Richards, Jürg Messer, Pari Malherbe, Richard Pink, Manfred Brockhaus, Vincent Mutel

J Comp Neurol· June 2005

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Modulation of serotonergic receptor signaling and cross-talk by prion protein.
Sophie Mouillet-Richard, Mathéa Pietri, Benoît Schneider, Catherine Vidal, Vincent Mutel

J Biol Chem· February 2005

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