Publications by authors named "Wataru Obuchi"

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Structure-based design, synthesis, and evaluation of tetrahydrotriazolothiazepine derivatives as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Yukinobu Numata, Toru Hasegawa, Makoto Mori, Tsuyoshi Shinozuka, Yuko Yamamoto, Wataru Obuchi

Bioorg Med Chem· January 2026

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DS-3939a: A TA-MUC1-directed Antibody-Drug Conjugate with Broad Anti-Tumor Activity.
Kohei Takano, Mayuko Yukiura, Kazuki Takahashi, Michiko Kitamura, Hiroko Okuno, Wataru Obuchi

Mol Cancer Ther· July 2025

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Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery.
Wataru Obuchi, Ayrton Zargani-Piccardi, Kevin Leandro, David Rufino-Ramos, Emilio Di Lanni

J Extracell Vesicles· June 2025

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Extracellular vesicles for the delivery of gene therapy.
Emilio Di Ianni, Wataru Obuchi, Koen Breyne, Xandra O Breakefield

Nat Rev Bioeng· May 2025

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Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity.
Hideaki Kageji, Takayuki Momose, Masayuki Ebisawa, Yusuke Nakazawa, Hiroyuki Okada, Wataru Obuchi

Bioorg Med Chem· September 2024

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RNA interference activity of single-stranded oligonucleotides linked between the passenger strand and the guide strand with an aryl phosphate linker.
Makoto Koizumi, Yasuhide Hirota, Makiko Nakayama, Masakazu Tamura, Wataru Obuchi

Nucleosides Nucleotides Nucleic Acids· July 2024

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Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models.
Genzui Setsu, Megumi Goto, Kentaro Ito, Tomoe Taira, Masaya Miyamoto, Wataru Obuchi

Eur J Pharmacol· December 2023

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Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers.
Katia E Maalouf, Christine A Vaine, Dawn M Frederick, Akiko Yoshinaga, Wataru Obuchi

Mol Ther· July 2023

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Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver.
Hiroyuki Ichida, Tatsuki Fukami, Keito Amai, Kohei Suzuki, Kenji Mishiro, Wataru Obuchi

Drug Metab Dispos· January 2023

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Estimation of fraction of drug metabolism by a single UDP-glucuronosyl transferase enzyme using relative expression factor.
Tomoyo Honda, Wataru Obuchi, Yumi Nishiya, Takahiro Shibayama, Kengo Watanabe

Biopharm Drug Dispos· October 2022

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Design of 2'--methyl RNA and DNA double-stranded oligonucleotides: naturally-occurring nucleotide components with strong RNA interference gene expression inhibitory activity.
Makoto Koizumi, Yasuhide Hirota, Makiko Nakayama, Masakazu Tamura, Wataru Obuchi

Nucleosides Nucleotides Nucleic Acids· September 2020

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Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.
Eisuke Miyauchi, Takuya Furuta, Sumio Ohtsuki, Masanori Tachikawa, Yasuo Uchida, Wataru Obuchi

PLoS One· June 2018

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Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.
Kenji Nakamura, Mio Hirayama-Kurogi, Shingo Ito, Takuya Kuno, Toshihiro Yoneyama, Wataru Obuchi

Proteomics· August 2016

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Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS.
Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Kenji Nakamura, Chise Tateno, Wataru Obuchi

Drug Metab Dispos· June 2014

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A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice.
Yasuo Uchida, Masanori Tachikawa, Wataru Obuchi, Yutaro Hoshi, Yusuke Tomioka

Fluids Barriers CNS· June 2013

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Identification of transporters associated with Etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics.
Wataru Obuchi, Sumio Ohtsuki, Yasuo Uchida, Ken Ohmine, Takao Yamori

Mol Pharmacol· February 2013

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