Publications by authors named "Wayne C Guida"

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Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor.
Robert P Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Wayne C Guida

ACS Cent Sci· June 2025

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Chemical synthesis, in vitro testing, and in silico Nampt-based molecular docking of novel aniline aromatic ring-substituted 2-aminothiazole analogs.
Ali A Husain, Ravikumar Manickam, Jonah Gordon, Sandhya Santhana, Katarzyna Mizgalska, Wayne C Guida

Can J Physiol Pharmacol· March 2025

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Correction: A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.
Robert P Sparks, Andres S Arango, Matthew L Starr, Zachary L Aboff, Logan R Hurst, Wayne C Guida

J Biol Chem· November 2022

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Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β-hairpin-like scaffold, MTI-101.
Priyesh Jain, David B Badger, Yi Liang, Anthony W Gebhard, Daniel Santiago, Wayne C Guida

Pept Sci (Hoboken)· May 2021

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An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9, and LDLR in Hepatocytes.
Robert P Sparks, Andres S Arango, Jermaine L Jenkins, Wayne C Guida, Emad Tajkhorshid

Biochemistry· November 2020

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A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.
Robert P Sparks, Andres S Arango, Matthew L Starr, Zachary L Aboff, Logan R Hurst, Wayne C Guida

J Biol Chem· November 2019

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Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from .
Sumit Handa, Daniel R Dempsey, Divya Ramamoorthy, Nanci Cook, Wayne C Guida

Biochem Mol Biol J· January 2018

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Molecular Dynamics Simulations of Membrane-Bound STIM1 to Investigate Conformational Changes during STIM1 Activation upon Calcium Release.
Sreya Mukherjee, Aleksandra Karolak, Marjolaine Debant, Paul Buscaglia, Yves Renaudineau, Wayne C Guida

J Chem Inf Model· February 2017

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Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding.
Robert P Sparks, Jermaine L Jenkins, Gregory E Miner, Yan Wang, Wayne C Guida

Biochem Biophys Res Commun· October 2016

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Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells.
Robert P Sparks, Wayne C Guida, Mark P Sowden, Jermaine L Jenkins, Matthew L Starr

Biochem Biophys Res Commun· September 2016

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Cupriphilic compounds to aid in proteasome inhibition.
Sreya Mukherjee, Robert Sparks, Rainer Metcalf, Wesley Brooks, Kenyon Daniel, Wayne C Guida

Bioorg Med Chem Lett· August 2016

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β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.
Chang Won Kang, Matthew P Sarnowski, Sujeewa Ranatunga, Lukasz Wojtas, Rainer S Metcalf, Wayne C Guida

Chem Commun (Camb)· November 2015

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A computational design approach for virtual screening of peptide interactions across K(+) channel families.
Craig A Doupnik, Katherine C Parra, Wayne C Guida

Comput Struct Biotechnol J· February 2015

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Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
R Matthew Cross, David L Flanigan, Andrii Monastyrskyi, Alexis N LaCrue, Fabián E Sáenz, Wayne C Guida

J Med Chem· November 2014

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In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery.
Christopher O Campbell, Daniel N Santiago, Wayne C Guida, Roman Manetsch, John H Adams

Chem Biol Drug Des· August 2014

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Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli.
Sumit Handa, Divya Ramamoorthy, Tyler J Spradling, Wayne C Guida, John H Adams

FEBS Open Bio· June 2013

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Development of new -Arylbenzamides as STAT3 Dimerization Inhibitors.
Murali K Urlam, Roberta Pireddu, Yiyu Ge, Xiaolei Zhang, Ying Sun, Wayne C Guida

Medchemcomm· June 2013

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Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors.
Sevil Ozcan, Aslamuzzaman Kazi, Frank Marsilio, Bin Fang, Wayne C Guida

J Med Chem· May 2013

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Identification of a new binding site in E. coli FabH using Molecular dynamics simulations: validation by computational alanine mutagenesis and docking studies.
Divya Ramamoorthy, Edward Turos, Wayne C Guida

J Chem Inf Model· May 2013

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A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation.
Xiaolei Zhang, Ying Sun, Roberta Pireddu, Hua Yang, Murali K Urlam, Wayne C Guida

Cancer Res· March 2013

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Virtual target screening: validation using kinase inhibitors.
Daniel N Santiago, Yuri Pevzner, Ashley A Durand, MinhPhuong Tran, Rachel R Scheerer, Wayne C Guida

J Chem Inf Model· August 2012

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Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).
Roberta Pireddu, Kara D Forinash, Nan N Sun, Mathew P Martin, Shen-Shu Sung, Wayne C Guida

Medchemcomm· June 2012

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Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.
Yiyu Ge, Aslamuzzaman Kazi, Frank Marsilio, Yunting Luo, Sanjula Jain, Wayne C Guida

J Med Chem· March 2012

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Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.
Rongshi Li, Mathew P Martin, Yan Liu, Binglin Wang, Ronil A Patel, Wayne C Guida

J Med Chem· March 2012

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Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
Latanya M Scott, Liwei Chen, Kenyon G Daniel, Wesley H Brooks, Wayne C Guida

Bioorg Med Chem Lett· January 2011

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