Publications by authors named "Wayne Grant"

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Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.
Jun Yong Choi, Yoshihiko Noguchi, James M Alburger, Simon Bayle, Eugene Chung, Wayne Grant

J Med Chem· June 2023

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Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase.
Francesca Vena, Simon Bayle, Ainhoa Nieto, Victor Quereda, Massimiliano Aceti, Wayne Grant

Mol Cancer Ther· August 2020

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βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Ainhoa Nieto, Makoto R Hara, Victor Quereda, Wayne Grant, Vanessa Saunders

Cell Death Differ· April 2020

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Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors.
Andrii Monastyrskyi, Simon Bayle, Victor Quereda, Wayne Grant, Michael Cameron

Bioorg Med Chem Lett· February 2018

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Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer.
Andrii Monastyrskyi, Napon Nilchan, Victor Quereda, Yoshihiko Noguchi, Claudia Ruiz, Wayne Grant

Bioorg Med Chem· February 2018

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HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.
Spencer D Wood, Wayne Grant, Isabel Adrados, Jun Yong Choi, James M Alburger

ACS Med Chem Lett· December 2017

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Therapeutic targeting of casein kinase 1δ in breast cancer.
Laura H Rosenberg, Marie Lafitte, Victor Quereda, Wayne Grant, Weimin Chen

Sci Transl Med· December 2015

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Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors.
Laura H Rosenberg, Marie Lafitte, Wayne Grant, Weimin Chen, John L Cleveland

J Biomol Screen· August 2015

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Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.
Yan Yin, Li Lin, Claudia Ruiz, Susan Khan, Michael D Cameron, Wayne Grant

J Med Chem· May 2013

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Amino acid derived quinazolines as Rock/PKA inhibitors.
Sarwat Chowdhury, Yen Ting Chen, Xingang Fang, Wayne Grant, Jennifer Pocas

Bioorg Med Chem Lett· March 2013

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Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).
Sarwat Chowdhury, E Hampton Sessions, Jennifer R Pocas, Wayne Grant, Thomas Schröter

Bioorg Med Chem Lett· December 2011

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Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II).
E Hampton Sessions, Sarwat Chowdhury, Yan Yin, Jennifer R Pocas, Wayne Grant

Bioorg Med Chem Lett· December 2011

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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Makoto R Hara, Jeffrey J Kovacs, Erin J Whalen, Sudarshan Rajagopal, Ryan T Strachan, Wayne Grant

Nature· August 2011

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Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.
Xingang Fang, Yen Ting Chen, E Hampton Sessions, Sarwat Chowdhury, Tomas Vojkovsky, Wayne Grant

Bioorg Med Chem Lett· March 2011

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Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.
Xingang Fang, Yan Yin, Yen Ting Chen, Lei Yao, Bo Wang, Wayne Grant

J Med Chem· August 2010

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Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats.
Yan Yin, Michael D Cameron, Li Lin, Susan Khan, Thomas Schröter, Wayne Grant

ACS Med Chem Lett· July 2010

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Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum.
Keke C Fairfax, Jon J Vermeire, Lisa M Harrison, Richard D Bungiro, Wayne Grant

Int J Parasitol· December 2009

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Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
Yan Yin, Li Lin, Claudia Ruiz, Michael D Cameron, Jennifer Pocas, Wayne Grant

Bioorg Med Chem Lett· December 2009

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Protease activation during in vivo pancreatitis is dependent on calcineurin activation.
Ahsan U Shah, Amna Sarwar, Abrahim I Orabi, Samir Gautam, Wayne M Grant

Am J Physiol Gastrointest Liver Physiol· November 2009

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Cyclic AMP accelerates calcium waves in pancreatic acinar cells.
Ahsan U Shah, Wayne M Grant, Sahibzada U Latif, Zahir M Mannan, Alexander J Park

Am J Physiol Gastrointest Liver Physiol· June 2008

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Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin.
Sohail Z Husain, Wayne M Grant, Fred S Gorelick, Michael H Nathanson, Ahsan U Shah

Am J Physiol Gastrointest Liver Physiol· June 2007

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Nucleoplasmic calcium is required for cell proliferation.
Michele A Rodrigues, Dawidson A Gomes, M Fatima Leite, Wayne Grant, Lei Zhang

J Biol Chem· June 2007

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Cyclic AMP-dependent protein kinase and Epac mediate cyclic AMP responses in pancreatic acini.
Anamika Chaudhuri, Sohail Z Husain, Thomas R Kolodecik, Wayne M Grant, Fred S Gorelick

Am J Physiol Gastrointest Liver Physiol· May 2007

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The ryanodine receptor mediates early zymogen activation in pancreatitis.
Sohail Z Husain, Priyajit Prasad, Wayne M Grant, Thomas R Kolodecik, Michael H Nathanson

Proc Natl Acad Sci U S A· October 2005

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Functional coupling of chromogranin with the inositol 1,4,5-trisphosphate receptor shapes calcium signaling.
Chi-Un Choe, Kenneth D Harrison, Wayne Grant, Barbara E Ehrlich

J Biol Chem· August 2004

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