Publications by authors named "Xavier Jacq"

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Deubiquitinating Enzyme UCH-L1 Regulates Neuronal Ca Signaling.
Marie Perrier, Desirée Loreth, Johannes Brand, Laurence Aubry, Timothy Harrison, Xavier Jacq

ACS Chem Neurosci· October 2025

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Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma.
Leanne Stevenson, Lauren Cairns, Xiaodun Li, Sriganesh Jammula, Harriet Taylor, Xavier Jacq

Sci Rep· December 2024

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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.
Anamarija Jurisic, Pei-Ju Sung, Mark Wappett, Julien Daubriac, Ian T Lobb, Xavier Jacq

Clin Transl Med· April 2024

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Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future.
Jeanine Harrigan, Xavier Jacq

Methods Mol Biol· January 2018

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Activity Based Profiling of Deubiquitylating Enzymes and Inhibitors in Animal Tissues.
Lauren McLellan, Cassie Forder, Aaron Cranston, Jeanine Harrigan, Xavier Jacq

Methods Mol Biol· January 2018

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Deubiquitylating enzymes and drug discovery: emerging opportunities.
Jeanine A Harrigan, Xavier Jacq, Niall M Martin, Stephen P Jackson

Nat Rev Drug Discov· January 2018

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A population-based analysis of germline BAP1 mutations in melanoma.
Sally J O'Shea, Carla Daniela Robles-Espinoza, Lauren McLellan, Jeanine Harrigan, Xavier Jacq

Hum Mol Genet· February 2017

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Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.
Jennifer A Ward, Lauren McLellan, Martin Stockley, Karl R Gibson, Gavin A Whitlock, Xavier Jacq

ACS Chem Biol· December 2016

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Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.
Lilyn Daftuar, Yan Zhu, Xavier Jacq, Carol Prives

PLoS One· February 2014

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Deubiquitylating enzymes and DNA damage response pathways.
Xavier Jacq, Mark Kemp, Niall M B Martin, Stephen P Jackson

Cell Biochem Biophys· September 2013

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Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry.
Yan Zhu, Kausik Regunath, Xavier Jacq, Carol Prives

Genes Dev· August 2013

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Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
Kevin M Foote, Kevin Blades, Anna Cronin, Shaun Fillery, Sylvie S Guichard, Xavier Jacq

J Med Chem· March 2013

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Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes.
Matteo Colombo, Stefania Vallese, Ilaria Peretto, Xavier Jacq, Jean-Christophe Rain

ChemMedChem· April 2010

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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.
Frédéric Colland, Etienne Formstecher, Xavier Jacq, Céline Reverdy, Cécile Planquette, Jacques Camonis

Mol Cancer Ther· August 2009

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Ribosomal protein S7 is both a regulator and a substrate of MDM2.
Yan Zhu, Masha V Poyurovsky, Yingchun Li, Lynn Biderman, Joachim Stahl, Xavier Jacq

Mol Cell· August 2009

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Functional proteomics mapping of a human signaling pathway.
Frédéric Colland, Xavier Jacq, Virginie Trouplin, Christelle Mougin, Caroline Groizeleau

Genome Res· July 2004

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Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization.
Masha V Poyurovsky, Xavier Jacq, Charles Ma, Orit Karni-Schmidt, Peter J Parker

Mol Cell· October 2003

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