Publications by authors named "Zemek Filip"

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Anticipated Social and Healthcare Economic Burden of People with Alzheimer's Disease in Two Selected Regions of the Czech Republic.
Petra Maresova, Lenka Komarkova, Jitka Kuhnova, Richard Cimler, Peter Pazitny, Filip Zemek

Healthcare (Basel)· October 2020

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Adamantane - A Lead Structure for Drugs in Clinical Practice.
Katarina Spilovska, Filip Zemek, Jan Korabecny, Eugenie Nepovimova, Ondrej Soukup

Curr Med Chem· February 2017

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Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine.
Filip Zemek, Lucie Drtinova, Eugenie Nepovimova, Vendula Sepsova, Jan Korabecny

Expert Opin Drug Saf· June 2014

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Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration.
Jana Zdarova Karasova, Filip Zemek, Martin Kunes, Jaroslav Kvetina, Jaroslav Chladek

Neuro Endocrinol Lett· May 2014

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Albumin and α1-acid glycoprotein: old acquaintances.
Zemek Filip, Korabecny Jan, Sepsova Vendula, Karasova Zdarova Jana, Musilek Kamil

Expert Opin Drug Metab Toxicol· August 2013

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Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics.
Filip Zemek, Jana Karasova Zdarova, Vendula Sepsova, Kamil Kuca

Int J Mol Sci· August 2013

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Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study.
Vendula Sepsova, Jana Zdarova Karasova, Jan Korabecny, Rafael Dolezal, Filip Zemek

Int J Mol Sci· August 2013

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Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system.
Jana Zdarova Karasova, Filip Zemek, Kamil Musilek, Kamil Kuca

Neurotox Res· January 2013

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Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.
Miroslav Pohanka, Filip Zemek, Hana Bandouchova, Jiri Pikula

Toxicol Mech Methods· April 2012

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Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
Miroslav Pohanka, Martina Hrabinova, Filip Zemek, Lucie Drtinova, Hana Bandouchova

Neuro Endocrinol Lett· April 2012

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[Intended pharmacotherapeutical approaches of Alzheimer's disease therapy].
Jan Korábecný, Eva Hrubá, Ondrej Soukup, Filip Zemek, Kamil Musílek

Ceska Slov Farm· February 2012

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Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.
Jan Korabecny, Kamil Musilek, Filip Zemek, Anna Horova, Ondrej Holas

Bioorg Med Chem Lett· November 2011

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Asoxime (HI-6) impact on dogs after one and tenfold therapeutic doses: assessment of adverse effects, distribution, and oxidative stress.
Miroslav Pohanka, Ladislav Novotny, Jana Zdarova-Karasova, Hana Bandouchova, Filip Zemek

Environ Toxicol Pharmacol· July 2011

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Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain.
Jana Zdarova Karasova, Filip Zemek, Jiri Bajgar, Martina Vasatova, Petr Prochazka

J Pharm Biomed Anal· April 2011

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Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
Jan Korabecny, Kamil Musilek, Ondrej Holas, Eugenie Nepovimova, Daniel Jun, Filip Zemek

Molecules· December 2010

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Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
Jan Korabecny, Kamil Musilek, Ondrej Holas, Jiri Binder, Filip Zemek

Bioorg Med Chem Lett· October 2010

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Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure.
Jana Zdarova Karasova, Miroslav Pohanka, Kamil Musilek, Filip Zemek, Kamil Kuca

Toxicol In Vitro· September 2010

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