Publications by authors named "Sepsova Vendula"

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Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova

J Enzyme Inhib Med Chem· December 2019

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Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.
Slavka Hamulakova, Ladislav Janovec, Ondrej Soukup, Daniel Jun, Jana Janockova, Vendula Sepsova

Curr Alzheimer Res· October 2019

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Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings.
Kamil Kuca, Jana Zdarova Karasova, Ondrej Soukup, Jiri Kassa, Eva Novotna, Vendula Sepsova

Drug Des Devel Ther· September 2018

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Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.
Dawid Panek, Anna Więckowska, Jakub Jończyk, Justyna Godyń, Marek Bajda, Vendula Sepsova

ACS Chem Neurosci· May 2018

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The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203.
Jiri Kassa, Jan Misik, Jana Hatlapatkova, Jana Zdarova Karasova, Vendula Sepsova

Molecules· July 2017

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Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.
Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost

Molecules· July 2017

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Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.
Katarina Spilovska, Jan Korabecny, Vendula Sepsova, Daniel Jun, Martina Hrabinova

Molecules· June 2017

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Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.
Zuzana Gazova, Ondrej Soukup, Vendula Sepsova, Katarina Siposova, Lucie Drtinova

Biochim Biophys Acta Mol Basis Dis· February 2017

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Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Jakub Jeřábek, Elisa Uliassi, Laura Guidotti, Jan Korábečný, Ondřej Soukup, Vendula Sepsova

Eur J Med Chem· February 2017

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The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
Mohamed Benchekroun, Alejandro Romero, Javier Egea, Rafael León, Patrycja Michalska, Vendula Sepsova

J Med Chem· November 2016

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Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.
Slavka Hamulakova, Patrik Poprac, Klaudia Jomova, Vlasta Brezova, Peter Lauro, Vendula Sepsova

J Inorg Biochem· August 2016

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Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.
Ondrej Benek, Ondrej Soukup, Marketa Pasdiorova, Lukas Hroch, Vendula Sepsova

ChemMedChem· June 2016

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7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.
Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Vendula Sepsova

Molecules· December 2015

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Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Eugenie Nepovimova, Jan Korabecny, Rafael Dolezal, Katerina Babkova, Ales Ondrejicek, Vendula Sepsova

J Med Chem· November 2015

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A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.
Jiri Kassa, Vendula Sepsova, Martina Tumova, Anna Horova, Kamil Musilek

Basic Clin Pharmacol Toxicol· April 2015

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Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.
Vendula Sepsova, Jana Z Karasova, Gunnar Tobin, Daniel Jun, Jan Korabecny

Gen Physiol Biophys· April 2015

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A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
Jiri Kassa, Vendula Sepsova, Lenka Matouskova, Anna Horova, Kamil Musilek

Toxicol Mech Methods· March 2015

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The evaluation of prophylactic efficacy of newly developed reversible inhibitors of acetylcholinesterase in soman-poisoned mice - a comparison with commonly used pyridostigmine.
Jiri Kassa, Jan Korabecny, Vendula Sepsova, Martina Tumova

Basic Clin Pharmacol Toxicol· December 2014

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7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Jan Korabecny, Rafael Dolezal, Pavla Cabelova, Anna Horova, Eva Hruba, Vendula Sepsova

Eur J Med Chem· July 2014

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Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine.
Filip Zemek, Lucie Drtinova, Eugenie Nepovimova, Vendula Sepsova, Jan Korabecny

Expert Opin Drug Saf· June 2014

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The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice.
Jiri Kassa, Vendula Sepsova, Martina Tumova, Kamil Musilek, Anna Horova

Toxicol Mech Methods· March 2014

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A resurrection of 7-MEOTA: a comparison with tacrine.
Ondrej Soukup, Daniel Jun, Jana Zdarova-Karasova, Jiri Patocka, Kamil Musilek, Vendula Sepsova

Curr Alzheimer Res· October 2013

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Albumin and α1-acid glycoprotein: old acquaintances.
Zemek Filip, Korabecny Jan, Sepsova Vendula, Karasova Zdarova Jana, Musilek Kamil

Expert Opin Drug Metab Toxicol· August 2013

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Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics.
Filip Zemek, Jana Karasova Zdarova, Vendula Sepsova, Kamil Kuca

Int J Mol Sci· August 2013

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Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study.
Vendula Sepsova, Jana Zdarova Karasova, Jan Korabecny, Rafael Dolezal, Filip Zemek

Int J Mol Sci· August 2013

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