Publications by authors named "Zhigen Hu"

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Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500.
Hong Myung Lee, Kojo Abdul-Hadi, Vicky A Appleman, David Cardin, Linlin Dong, Zhigen Hu, Jian Huang, Shih-Chung Huang

Bioconjug Chem· November 2025

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Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
Stepan Vyskocil, David Cardin, Jeffrey Ciavarri, Joe Conlon, Courtney Cullis, Zhigen Hu, Yongbo Hu, Jian Huang, Shih-Chung Huang, Luhua Shen

J Med Chem· May 2021

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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
Steven P Langston, Stephen Grossman, Dylan England, Roushan Afroze, Neil Bence, Bei-Ching Chuang, Shumet Hailu, Yongbo Hu, Zhigen Hu

J Med Chem· March 2021

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Using Improved Principal Component Analysis to Explore Construction Accident Situations from the Multi-Dimensional Perspective: A Chinese Study.
Bo Shao, Zhigen Hu, Dawei Liu

Int J Environ Res Public Health· September 2019

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.
Xingyue He, Jessica Riceberg, Teresa Soucy, Erik Koenig, James Minissale, Hugues Bernard, Hua Liao, Zhong-Hua Yan, Zhigen Hu

Nat Chem Biol· November 2017

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Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action.
Bulbul Pandit, Zhigen Hu, Somsundaram N Chettiar, Jennifer Zink, Zili Xiao

Bioorg Med Chem Lett· December 2013

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Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Christopher Blackburn, Cynthia Barrett, Jonathan L Blank, Frank J Bruzzese, Nancy Bump, Zhigen Hu

Bioorg Med Chem Lett· November 2010

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Inhibitors of NF-kappaB derived from thalidomide.
Esperanza J Carcache de-Blanco, Bulbul Pandit, Zhigen Hu, Jiandong Shi, Andrew Lewis

Bioorg Med Chem Lett· November 2007

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Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.
Bulbul Pandit, Yanjun Sun, Ping Chen, Dan L Sackett, Zhigen Hu

Bioorg Med Chem· October 2006

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A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities.
Pui-Kai Li, Bulbul Pandit, Dan L Sackett, Zhigen Hu, Jennifer Zink

Mol Cancer Ther· February 2006

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Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Pui-Kai Li, Zili Xiao, Zhigen Hu, Bulbul Pandit, Yanjun Sun

Bioorg Med Chem Lett· December 2005

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Structure-activity relationships studies of the anti-angiogenic activities of linomide.
Jiandong Shi, Zili Xiao, Michael A Ihnat, Chandrashekhar Kamat, Bulbul Pandit, Zhigen Hu

Bioorg Med Chem Lett· March 2003

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