Circulation February 2016 PMID 26819376

The Failing Heart Relies on Ketone Bodies as a Fuel.

Gregory Aubert, Ola J Martin, Julie L Horton, Ling Lai, Rick B Vega, Teresa C Leone, Timothy Koves, Stephen J Gardell, Marcus Krüger, Charles L Hoppel, E Douglas Lewandowski, Peter A Crawford, Deborah M Muoio, Daniel P Kelly

Download social card

Mentions

54
Peak: 7 in Nov 2023
across 4 sources since Feb 2019

Extended reach

929,384
potential audience

Total likes

4,511

Video views

166,905

Mentions per month

Feb 2019 – May 2024

Where it's discussed

  • X / Twitter40 posts
  • News9 articles
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate a high interest in the metabolic role of ketones in failing hearts, with posts emphasizing their significance using terms like 'rely on ketone bodies' and 'fuel for the failing heart.' Several comments delve into mechanisms, such as mitochondrial stress reduction and ATP production, illustrating deep engagement with scientific details. The tone varies from supportive to questioning, highlighting the ongoing debate about the clinical relevance of these findings.

AgreementModerate agreement

Most discussions support the idea that ketones play a beneficial role in heart failure, emphasizing their importance and validity based on recent research.

InterestHigh interest

The posts show a high level of curiosity and engagement with complex metabolic mechanisms, indicating strong interest in the biomedical implications.

EngagementHigh engagement

Numerous replies reference technical details, studies, and potential clinical applications, reflecting deep engagement with the subject matter.

ImpactModerate impact

While some speakers highlight potential therapeutic impacts, the overall influence on clinical practice remains speculative, resulting in a moderate impact rating.

Abstract in brief

  • The failing heart lacks energy and struggles to use fatty acids, its primary fuel, during heart failure development.
  • Using advanced proteomics, researchers found that the failing heart shows decreased fatty acid utilization proteins and increased levels of enzymes for ketone oxidation.
  • The study reveals that as the heart fails, it shifts to using ketone bodies for energy, identifying specific metabolic signatures that could lead to new treatment approaches for heart failure.

Top posts

Most liked on X and Bluesky
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

This is for those who think that Ketogenic Diet is bad for the heart.. Check the below: "The Failing Heart Relies on Ketone Bodies as a Fuel" https://t.co/9QeW6FD1SM

Nov 21, 2023 · 29 likes · 5 shares · 29,057 followers View post →
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

Anyone who says that ketones are bad for the heart are simply ignorant or have very less time to do research or are in their own rabbit hole. "The Failing Heart Relies on Ketone Bodies as a Fuel" "These results indicate that the hypertrophied and failing heart shifts to ketone https://t.co/rWm7twYGFa

May 7, 2024 · 21 likes · 4 shares · 29,057 followers View post →
Tim Noakes
@ProfTimNoakes · X

@DuskVegan @colintan18 @Veganella_ @ukmav @BelindaFettke @lowcarbGP @PeterBrukner @zoeharcombe @GeorgiaEdeMD @SBakerMD @FructoseNo @garytaubes @TuitNutrition From a viral myocarditis that has no known relationship to diet but the effects of which might have been partially allayed by a low carbohydrate ketogenic diet https://t.co/zjCP8hKYAC, worsened by a high carbohydrate diet.

Oct 21, 2019 · 14 likes · 1 share · 158,279 followers View post →
David Diamond
@LDLSkeptic · X

@DrScottMurray @eatmostlyfatali @ProfDFrancis @FatEmperor @bridgesuite @MaryanneDemasi @DrAseemMalhotra @fgodlee @drjohnm @PGtzsche1 @DrVikasSaini @drjoesDIYhealth @RFRedberg @AKECassels @ProfTimNoakes @EricThornMD @BJSM_BMJ @EricTopol @DrPascalMeier @MichaelWestBiz @cardiobrief @FructoseNo @DrDavidWarriner @ProfKausikRay vitamin C to reverse organ failure with sepsis https://t.co/IlyZ7Xdgjt https://t.co/jdehbJMH4c and ketones for heart failure https://t.co/1Adjnc9XiM

Feb 8, 2019 · 12 likes · 5 shares · 45,071 followers View post →
David Diamond
@LDLSkeptic · X

@eatmostlyfatali @OZmandia @meganjramos @drjasonfung @FatEmperor @JeffryGerberMD @awokelife @weamonette @ESodicoffMD @Rezaidi Brilliant presentation Nadir. As to exo-ketones: Your studies were on healthy, fasted ppl. What of the damaged heart/brain? Evidence of exo-ketone benefit for heart failure & MCI/AD: https://t.co/GfqUWzkwrb DOI: 10.1161/CIRCULATIONAHA.115.017355 DOI: 10.1016/j.jalz.2018.12.017

Jun 2, 2020 · 10 likes · 1 share · 45,071 followers View post →
Adrian Soto-Mota
@AdrianSotoMota · X

ESPECIALLY the failing heart. https://t.co/gRARNQ0iTD

Jan 31, 2022 · 9 likes · 1 share · 9,204 followers View post →

All mentions

MK
@KhameemrK · X

RT @shashiiyengar: Anyone who says that ketones are bad for the heart are simply ignorant or have very less time to do research or are in t…

May 10, 2024 · 4 shares · 1,054 followers View post →
J P Fanton
@HealthyFellow · X

RT @shashiiyengar: Anyone who says that ketones are bad for the heart are simply ignorant or have very less time to do research or are in t…

May 7, 2024 · 4 shares · 26,002 followers View post →
eagleeye192020 Proud Hindu &Indian-Modi Ka Parivar
@eagleeye192020 · X

RT @shashiiyengar: Anyone who says that ketones are bad for the heart are simply ignorant or have very less time to do research or are in t…

May 7, 2024 · 4 shares · 1,418 followers View post →
smart guy
@smartguy7555 · X

RT @shashiiyengar: Anyone who says that ketones are bad for the heart are simply ignorant or have very less time to do research or are in t…

May 7, 2024 · 4 shares · 329 followers View post →
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

Anyone who says that ketones are bad for the heart are simply ignorant or have very less time to do research or are in their own rabbit hole. "The Failing Heart Relies on Ketone Bodies as a Fuel" "These results indicate that the hypertrophied and failing heart shifts to ketone https://t.co/rWm7twYGFa

May 7, 2024 · 21 likes · 4 shares · 29,057 followers View post →
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

@DipakRanjanPra9 This is from a reputed journal But Drs rarely read these. They just parrot what guidelines say he Failing Heart Relies on Ketone Bodies as a Fuel https://t.co/uoa6SPoUsQ

May 7, 2024 · 1 like · 29,057 followers View post →
Siddesh G :: Metabolic Health Coach
@sixersiddu · X

RT @shashiiyengar: This is for those who think that Ketogenic Diet is bad for the heart.. Check the below: "The Failing Heart Relies on K…

Nov 22, 2023 · 5 shares · 519 followers View post →
Javed Alam
@jalam1001 · X

RT @shashiiyengar: This is for those who think that Ketogenic Diet is bad for the heart.. Check the below: "The Failing Heart Relies on K…

Nov 21, 2023 · 5 shares · 1,011 followers View post →
J P Fanton
@HealthyFellow · X

RT @shashiiyengar: This is for those who think that Ketogenic Diet is bad for the heart.. Check the below: "The Failing Heart Relies on K…

Nov 21, 2023 · 5 shares · 26,002 followers View post →
Dr.Tanmoy Das, MD
@drtanmoy · X

The Failing Heart Relies on Ketone Bodies as a Fuel.. https://t.co/MrYv9rCU3f

Nov 21, 2023 · 2 likes · 2,756 followers View post →
Dr. Jasmeet Kaur (PhD)
@jasmeet481 · X

RT @shashiiyengar: This is for those who think that Ketogenic Diet is bad for the heart.. Check the below: "The Failing Heart Relies on K…

Nov 21, 2023 · 5 shares · 4,166 followers View post →
Andy
@AndyBajaj53 · X

RT @shashiiyengar: This is for those who think that Ketogenic Diet is bad for the heart.. Check the below: "The Failing Heart Relies on K…

Nov 21, 2023 · 5 shares · 330 followers View post →
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

This is for those who think that Ketogenic Diet is bad for the heart.. Check the below: "The Failing Heart Relies on Ketone Bodies as a Fuel" https://t.co/9QeW6FD1SM

Nov 21, 2023 · 29 likes · 5 shares · 29,057 followers View post →
Douglas Ritz
@douglasritz · X

@ChrisPalmerMD Always remember, your heart loves fatty acids and ketones. https://t.co/ZNmgr1WIlt

Apr 19, 2023 · 3 likes · 5,207 followers View post →
Felipe Isidro
@felipeisidro13 · X

@almucastro01 @JTLLERGO @CircAHA @secardiologia @SACardiologia @DrTinahones @CristobMorales @MAROSFO @clinica_sec @yulnunezvill @Dr_Manito @rdelaespriella @ValleAlfonso @sociedadSEEN @AndrewJSauer @robmentz @SantosGallegoMD @JavedButler1 @ShahzebKhanMD @HFpEF Si bien es un biomarcador de enfermedad, el aumento de KB podría reflejar un mecanismo de protección, proporcionando una fuente de energía eficiente y alternativa en un entorno de disfunción mitocondrial https://t.co/21S9eAm5Nm

Apr 2, 2023 · 4 likes · 16,800 followers View post →
Muzzpol
@Muzzpol · X

RT @shashiiyengar: "The Failing Heart Relies on Ketone Bodies as a Fuel" @lowcarbusa @NutritionNetwrk @TheSMHP @drericwestman https://t.co…

Sep 10, 2022 · 3 shares · 860 followers View post →
J P Fanton
@HealthyFellow · X

RT @shashiiyengar: "The Failing Heart Relies on Ketone Bodies as a Fuel" @lowcarbusa @NutritionNetwrk @TheSMHP @drericwestman https://t.co…

Sep 10, 2022 · 3 shares · 26,002 followers View post →
Sanj
@Mindzatwork · X

RT @shashiiyengar: "The Failing Heart Relies on Ketone Bodies as a Fuel" @lowcarbusa @NutritionNetwrk @TheSMHP @drericwestman https://t.co…

Sep 8, 2022 · 3 shares · 1,687 followers View post →
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

"The Failing Heart Relies on Ketone Bodies as a Fuel" @lowcarbusa @NutritionNetwrk @TheSMHP @drericwestman https://t.co/CIlXqxtyDI https://t.co/mmd4PppXvV

Sep 8, 2022 · 4 likes · 3 shares · 29,057 followers View post →
Ben L. ن⚡️
@BNLieb · X

RT @Ad_SotoMota: ESPECIALLY the failing heart. https://t.co/gRARNQ0iTD

Jan 31, 2022 · 1 share · 11,647 followers View post →
Adrian Soto-Mota
@AdrianSotoMota · X

ESPECIALLY the failing heart. https://t.co/gRARNQ0iTD

Jan 31, 2022 · 9 likes · 1 share · 9,204 followers View post →
Shashi Iyengar | Metabolic Health India®
@shashiiyengar · X

Fat is inefficient fuel?? Carbs are.. A failing heart depends on fat for fuel Why?? @dlifein https://t.co/CIlXqxt0Oa https://t.co/HtCGn36pV3

Mar 9, 2021 · 4 likes · 29,057 followers View post →
Nadir
@eatmostlyfatali · X

RT @LDLSkeptic: @eatmostlyfatali @OZmandia @meganjramos @drjasonfung @FatEmperor @JeffryGerberMD @awokelife @weamonette @ESodicoffMD @Rezai…

Jun 2, 2020 · 1 share · 14,929 followers View post →
David Diamond
@LDLSkeptic · X

@eatmostlyfatali @OZmandia @meganjramos @drjasonfung @FatEmperor @JeffryGerberMD @awokelife @weamonette @ESodicoffMD @Rezaidi Brilliant presentation Nadir. As to exo-ketones: Your studies were on healthy, fasted ppl. What of the damaged heart/brain? Evidence of exo-ketone benefit for heart failure & MCI/AD: https://t.co/GfqUWzkwrb DOI: 10.1161/CIRCULATIONAHA.115.017355 DOI: 10.1016/j.jalz.2018.12.017

Jun 2, 2020 · 10 likes · 1 share · 45,071 followers View post →
Ahmad Zahar
@Kuahmd · X

Keto Diet Jantung yang Gagal Bergantung pada Tubuh Keton sebagai Bahan Bakar Gregory Aubert , MD, PhD Ola J. Martin , PhD Julie L. Horton , NONA Ling Lai , MD, PhD Rick B. Vega , PhD Teresa C. Leone... https://t.co/0FOhursF1m

Jan 23, 2020 · 783 followers View post →
Ahmad Zahar
@Kuahmd · X

FREE ACCESSARTICLE The Failing Heart Relies on Ketone Bodies as a Fuel Gregory Aubert, MD, PhD Ola J. Martin, PhD Julie L. Horton, MS Ling Lai, MD, PhD Rick B. Vega, PhD Teresa C. Leone, BS Timothy Koves, PhD... https://t.co/0FOhursF1m

Jan 23, 2020 · 783 followers View post →
Tim Noakes
@ProfTimNoakes · X

@DuskVegan @colintan18 @Veganella_ @ukmav @BelindaFettke @lowcarbGP @PeterBrukner @zoeharcombe @GeorgiaEdeMD @SBakerMD @FructoseNo @garytaubes @TuitNutrition From a viral myocarditis that has no known relationship to diet but the effects of which might have been partially allayed by a low carbohydrate ketogenic diet https://t.co/zjCP8hKYAC, worsened by a high carbohydrate diet.

Oct 21, 2019 · 14 likes · 1 share · 158,279 followers View post →
Brett L. ©
@StickmanBleedin · X

RT @fancypirate8: Study on ketones and heart failure. "This fuel utilization pathway could prove to be a new candidate target for metaboli…

Oct 19, 2019 · 4 shares · 22,833 followers View post →
David Wyant
@wyadvd · X

RT @fancypirate8: Study on ketones and heart failure. "This fuel utilization pathway could prove to be a new candidate target for metaboli…

Oct 18, 2019 · 4 shares · 2,696 followers View post →
Jason | Chuck Roll Patrol
@fancypirate8 · X

Study on ketones and heart failure. "This fuel utilization pathway could prove to be a new candidate target for metabolic modulatory therapies aimed at early stages of heart failure." @vincentninja68 @Mangan150 https://t.co/KTJUHJr0RX

Oct 18, 2019 · 9 likes · 4 shares · 4,692 followers View post →
ZKA
@0knowledgeactor · X

@hswapnil @PareshJ41087444 @kidney_boy @drjohnm If SGLT2is' benefit is derived from inducing ketosis and reduction of total body glucose, then why not do similarly with diet, especially since ketones seem important to failing myocardium. https://t.co/5VMiV9pWN3 https://t.co/8UhPXtcwnW https://t.co/M6so3fqotm

Sep 7, 2019 · 1,184 followers View post →
Dave Ambo
@DaveAmbo · X

RT @I_mitochondria: The Failing Heart Relies on Ketone Bodies as a Fuel. BHB oxidation=>ATP/oxygen &= >Gibbs free energy potential/ATP. Hel…

Sep 4, 2019 · 1 share · 828 followers View post →
Isabella Cooper
@I_mitochondria · X

The Failing Heart Relies on Ketone Bodies as a Fuel. BHB oxidation=>ATP/oxygen &= >Gibbs free energy potential/ATP. Helps decrease ROS production from mitochondrial stress ⁦@davidludwigmd⁩ ⁦@garytaubes⁩ ⁦@BenBikmanPhD⁩ ⁦@SBakerMD⁩ https://t.co/2EsS9qg0Y6

Aug 30, 2019 · 5 likes · 1 share · 10,784 followers View post →
DiscoStew
@DiscoStew66 · X

@davidludwigmd https://t.co/R72xSNVp0p

Mar 26, 2019 · 5 likes · 10,792 followers View post →
ketoalldayeveryday
@ketoalldayevery · X

RT @LDLSkeptic: @DrScottMurray @eatmostlyfatali @ProfDFrancis @FatEmperor @bridgesuite @MaryanneDemasi @DrAseemMalhotra @fgodlee @drjohnm @…

Feb 9, 2019 · 5 shares · 43 followers View post →
Pathfinder
@Nordic_Nog · X

RT @LDLSkeptic: @DrScottMurray @eatmostlyfatali @ProfDFrancis @FatEmperor @bridgesuite @MaryanneDemasi @DrAseemMalhotra @fgodlee @drjohnm @…

Feb 8, 2019 · 5 shares · 545 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

RT @LDLSkeptic: @DrScottMurray @eatmostlyfatali @ProfDFrancis @FatEmperor @bridgesuite @MaryanneDemasi @DrAseemMalhotra @fgodlee @drjohnm @…

Feb 8, 2019 · 5 shares · 253 followers View post →
Tim Noakes
@ProfTimNoakes · X

RT @LDLSkeptic: @DrScottMurray @eatmostlyfatali @ProfDFrancis @FatEmperor @bridgesuite @MaryanneDemasi @DrAseemMalhotra @fgodlee @drjohnm @…

Feb 8, 2019 · 5 shares · 158,279 followers View post →
David Diamond
@LDLSkeptic · X

@DrScottMurray @eatmostlyfatali @ProfDFrancis @FatEmperor @bridgesuite @MaryanneDemasi @DrAseemMalhotra @fgodlee @drjohnm @PGtzsche1 @DrVikasSaini @drjoesDIYhealth @RFRedberg @AKECassels @ProfTimNoakes @EricThornMD @BJSM_BMJ @EricTopol @DrPascalMeier @MichaelWestBiz @cardiobrief @FructoseNo @DrDavidWarriner @ProfKausikRay vitamin C to reverse organ failure with sepsis https://t.co/IlyZ7Xdgjt https://t.co/jdehbJMH4c and ketones for heart failure https://t.co/1Adjnc9XiM

Feb 8, 2019 · 12 likes · 5 shares · 45,071 followers View post →
Jan Vyjidak
@janvyjidak · X

@upyrbike @KetoAnaesMD would that have any relevance in HF? Aubert (2016) https://t.co/yyQttU2Tpp

Feb 2, 2019 · 1 like · 4,143 followers View post →