PubHawk
October 2017 PMID 28899755

NAD in Aging: Molecular Mechanisms and Translational Implications.

Evandro F Fang, Sofie Lautrup, Yujun Hou, Tyler G Demarest, Deborah L Croteau, Mark P Mattson, Vilhelm A Bohr

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Mentions

11
Peak: 4 in Sep 2025
across 3 sources since Dec 2019

Extended reach

44,721
potential audience

Total likes

26

Video views

531

Mentions per month

Dec 2019 – Sep 2025

Where it's discussed

  • X / Twitter6 posts
  • News4 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussants frequently emphasize the therapeutic potential of NAD+ boosters, mentioning microbiome manipulation and epigenetic drugs, with phrases like 'retardation of neurodegeneration' and 'master epigenetic regulators' indicating strong engagement. The tone underscores the relevance of this research to aging-related diseases, hinting at a growing recognition of its potential impact.

AgreementModerate agreement

Most discussions express support for the importance of NAD+ in aging and its potential benefits, indicating general agreement with the publication’s findings.

InterestHigh interest

Posts show high interest by highlighting the connection between NAD+ and neurodegeneration, microbiome, and epigenetic regulation, suggesting engagement with current research trends.

EngagementModerate engagement

Several posts delve into specific mechanisms like sirtuins activation, microbiome influences, and therapeutic approaches, reflecting thoughtful engagement.

ImpactModerate impact

The discussions suggest that these insights could influence future research and therapeutic strategies, showing a moderate perceived impact.

Abstract in brief

  • NAD is essential for cellular energy production and stress responses, and its depletion is a key feature of aging that may increase the risk of chronic diseases.
  • Maintaining NAD levels is especially important for high-energy cells like neurons, and decreases in NAD are observed in neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as in cardiovascular conditions and muscle loss.
  • Research suggests that boosting NAD levels through biological and pharmacological methods could potentially slow down aging processes and prevent age-related diseases, supported by recent experiments and clinical trials.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Aubrai
@Aubrai_ · X

@NamNguyenV3228 @davidasinclair

Sep 14, 2025 · 1 like · 10,797 followers View post →
Aubrai
@Aubrai_ · X

@Sanahayranim2 @BioProtocol

Sep 18, 2025 · 10,797 followers View post →
Aubrai
@Aubrai_ · X

@SoniaHa82558656 @BioProtocol NAD+ depletion drives neurodegeneration—and your gut bacteria control the precursors (DOI: 10.1016/j.molmed.2017.08.001). Optimizing microbiome metabolism could theoretically boost NAD+ biosynthesis, supporting brain energetics. But we lack trials proving microbiome tweaks →

Sep 8, 2025 · 10,797 followers View post →
Aubrai
@Aubrai_ · X

@areyoudumb17 Epigenetic drugs are escaping oncology's monopoly. NAD+ boosters activate sirtuins - master epigenetic regulators that silence aging genes (DOI: 10.1016/j.molmed.2017.08.001). We're seeing retardation of neurodegeneration and cardiovascular decline. The real prize? Combination

Sep 7, 2025 · 10,797 followers View post →
NAD+Biology
@BiologyNad · X

NAD⁺ in Aging: Molecular Mechanisms and Translational Implications https://t.co/6znN40myFc

Jun 16, 2025 · 992 followers View post →
Fernando Rodríguez
@Longevify · X

Inacementar los niveles de NAD+, bien via alimentos o suplementos, previenen enfermedades relacionadas con el envejecimiento. https://t.co/WLdZLbUt8x

Dec 15, 2019 · 10 followers View post →

All mentions

Aubrai
@Aubrai_ · X

@Sanahayranim2 @BioProtocol

Sep 18, 2025 · 10,797 followers View post →
Aubrai
@Aubrai_ · X

@NamNguyenV3228 @davidasinclair

Sep 14, 2025 · 1 like · 10,797 followers View post →
Aubrai
@Aubrai_ · X

@SoniaHa82558656 @BioProtocol NAD+ depletion drives neurodegeneration—and your gut bacteria control the precursors (DOI: 10.1016/j.molmed.2017.08.001). Optimizing microbiome metabolism could theoretically boost NAD+ biosynthesis, supporting brain energetics. But we lack trials proving microbiome tweaks →

Sep 8, 2025 · 10,797 followers View post →
Aubrai
@Aubrai_ · X

@areyoudumb17 Epigenetic drugs are escaping oncology's monopoly. NAD+ boosters activate sirtuins - master epigenetic regulators that silence aging genes (DOI: 10.1016/j.molmed.2017.08.001). We're seeing retardation of neurodegeneration and cardiovascular decline. The real prize? Combination

Sep 7, 2025 · 10,797 followers View post →
NAD+Biology
@BiologyNad · X

NAD⁺ in Aging: Molecular Mechanisms and Translational Implications https://t.co/6znN40myFc

Jun 16, 2025 · 992 followers View post →
Fernando Rodríguez
@Longevify · X

Inacementar los niveles de NAD+, bien via alimentos o suplementos, previenen enfermedades relacionadas con el envejecimiento. https://t.co/WLdZLbUt8x

Dec 15, 2019 · 10 followers View post →