Cell April 2021 PMID 33831375

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.

Stefan C Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G Deshwar, Kaixian Yu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vázquez-García, Kortine Kleinheinz, Dimitri G Livitz, Salem Malikic, Nilgun Donmez

Download social card

Mentions

104

Peak: 71 in Apr 2021

across 4 sources since Apr 2020

Extended reach

452,629

potential audience

Total likes

165

Video views

1,179

Mentions per month

Apr 2020 – Nov 2024

Where it's discussed

X / Twitter77 posts
News22 articles
Blogs3 articles
YouTube2 videos

AI synopsis

What people are saying

Several posts reference the complexity of intra-tumor heterogeneity and express excitement about the comprehensive nature of the research. For instance, terms like 'extremely interesting' and 'seriously impressive paper' illustrate the positive tone. Discussions also mention the publication as a significant resource for understanding cancer evolution, indicating a strong consensus on its relevance and potential impact in the field.

AgreementModerate agreement

Overall, most discussions reflect a supportive view of the publication's findings, highlighting its complexity and relevance.

InterestHigh interest

Many posts express high interest in the topic of genetic intra-tumor heterogeneity and its implications for cancer treatment.

EngagementModerate engagement

While some posts display deeper engagement by referencing related articles and discussing methodologies, others are more surface-level.

ImpactHigh impact

Participants believe the publication will have a significant influence on cancer research and treatment approaches.

Abstract in brief

* Analysis of 2,658 whole-genome sequences reveals that 95.1% of samples show distinct subclonal expansions that evolve through branching relationships, highlighting the complexity within tumors.
* This study identifies specific patterns of driver mutations and other genetic alterations in different cancer types, offering valuable insight into tumor evolution and a resource for understanding subclonal events across cancers.

Read the full abstract

All mentions

Characterizing Intra-Tumor Heterogeneity in Cancer Genomes

Wenyi Wang discusses the computational analysis of 2,658 human cancer genomes revealing intra-tumor heterogeneity (ITH). This research highlights the complexity of tumors, showing that 95.1% exhibit distinct subclonal…

Computational Genomics Summer Institute CGSI · Oct 28, 2022 1,010 views

Genetic Intra-Tumor Heterogeneity in Cancer Development

This video examines the complexities of intra-tumor heterogeneity (ITH) in cancer. It highlights findings from the analysis of 2,658 whole-genome sequences, revealing that 95.1% of samples exhibit distinct subclonal…

Computational Genomics Summer Institute CGSI · Nov 1, 2024 170 views

Alex Frankell

@AFrankell · X

Inconsistent subclones between plasma and tissue tended to have been discovered in only a single tissue sample and to have a higher tissue CCF, consistent with a sampling bias called the Winner’s curse in tissue, described by @stefan_seq in https://t.co/HLR63K9iDL [10/13] https://t.co/sKIZlBmXoC

Apr 15, 2023 · 524 followers View post →

Hossein Moosavi

@hmoosavi_tw · X

Several great reads for those interested in genetic of metastases, ITH, and cancer evolution... https://t.co/khjrnsAVpk https://t.co/dIA4swaMe1 https://t.co/biqqhGB8c5 10.1016/j.ccell.2017.12.004 10.1038/s41586-019-1907-7 10.1038/s41591-021-01448-w 10.1038/s41568-021-00336-2

Feb 8, 2022 · 171 followers View post →

Helen Oram

@DrHelenOram · X

Seriously impressive paper Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/twC2wR7SF9 https://t.co/P49XG9I04Q

Dec 9, 2021 · 764 followers View post →

Dr.S.Harsha Vardhan

@harshambbs2012 · X

Characterizing Genetic Intra-Tumor Heterogeneity Across 2,658 Human Cancer Genomes https://t.co/tgX762L3cs

May 21, 2021 · 62 followers View post →

johnjljacobs

@johnjljacobs · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. https://t.co/QEpxluAC81

Apr 27, 2021 · 1,946 followers View post →

UCL Discovery

@ucl_discovery · X

Open Access UCL Research: Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes https://t.co/xuwlbt7kz9

Apr 21, 2021 · 2,524 followers View post →

the paper link

@the_paper_link · X

RT @the_paper_link: Trend up+7: Dentro SC, ..., Pcawg Evolution and Heterogeneity Working Group and the PCAWG Consortium (Cell) __Characte…

Apr 18, 2021 · 1 share · 137 followers View post →

the paper link

@the_paper_link · X

Trend up+7: Dentro SC, ..., Pcawg Evolution and Heterogeneity Working Group and the PCAWG Consortium (Cell) __Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes__ https://t.co/KY4FaXayJv

Apr 18, 2021 · 1 share · 137 followers View post →

Kyle Hernandez

@Evilution84 · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/8hQaQ9qbfN

Apr 17, 2021 · 1 like · 822 followers View post →

DryWetty

@DryWetty · X

PCAWG (Pan Cancer Analysis of Whole Genome) の新しい論文出てた。 Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/YeSu58UfmV

Apr 16, 2021 · 175 followers View post →

Inti De La Rosa Velazquez

@IntiOmics · X

Apr 16, 2021 · 3 likes · 1,399 followers View post →

Markus P. Vallaster

@Stigmehaimatine · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/ZMI8ABJhsA

Apr 15, 2021 · 77 followers View post →

Dr Alok Dixit

@Alokdoctor · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/5k765CfuVw

Apr 15, 2021 · 1,710 followers View post →

the paper link

@the_paper_link · X

Trend top+4: Dentro SC, ..., Pcawg Evolution and Heterogeneity Working Group and the PCAWG Consortium (Cell) __Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes__ https://t.co/KY4FaXsa85

Apr 12, 2021 · 137 followers View post →

Victoria Hendry

@HendryVictoria · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 11, 2021 · 41 shares · 1,324 followers View post →

CaldasLab

@CaldasLab · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 11, 2021 · 41 shares · 824 followers View post →

the paper link

@the_paper_link · X

RT @the_paper_link: Trend new: Dentro SC, ..., Pcawg Evolution and Heterogeneity Working Group and the PCAWG Consortium (Cell) __Character…

Apr 10, 2021 · 1 share · 137 followers View post →

the paper link

@the_paper_link · X

Trend new: Dentro SC, ..., Pcawg Evolution and Heterogeneity Working Group and the PCAWG Consortium (Cell) __Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes__ https://t.co/KY4FaXsa85

Apr 9, 2021 · 1 share · 137 followers View post →

K-Iemura

@ieken5916 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 9, 2021 · 41 shares · 165 followers View post →

Liliya Kopanitsa

@LiliyaLvk21mail · X

RT @sangerinstitute:

Apr 9, 2021 · 2 shares · 71 followers View post →

Merisa Cenanovic

@MerisaCenanovic · X

RT @sangerinstitute:

Apr 9, 2021 · 2 shares · 961 followers View post →

David Rubio

@David_Rubiom · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes https://t.co/mhhlI4mDXg

Apr 9, 2021 · 288 followers View post →

Wellcome Sanger Institute

@sangerinstitute · X

Apr 9, 2021 · 2 likes · 2 shares · 72,005 followers View post →

Paperbirds_Oncology

@PaperbirdsO · X

New article: Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes https://t.co/obvj4DQugv #prostatecancer #oncology https://t.co/kQwutetrDl

Apr 9, 2021 · 891 followers View post →

Nuria Gago lopez

@NuriaGagolopez1 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 8, 2021 · 41 shares · 174 followers View post →

UNIBO B2F2 PhD Program

@B2f2Phd · X

This huge work created a pan-cancer resource of comprehensively annotated intra-tumor heterogeneity from WGS data. Extremely interesting! https://t.co/jpuBJlOK3m

Apr 8, 2021 · 3 likes · 334 followers View post →

AnonRere

@AnonRere · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes https://t.co/eVEXnS4rhc

Apr 8, 2021 · 2,223 followers View post →

Jeff Wintersinger

@jwintersinger · X

@DrPMartinez In PCAWG (https://t.co/HAuFXcJceU), with WGS at ~50x, we could typically resolve two or three subclones from single samples. More robust diversity measures than MATH may still be useful for those settings.

Apr 8, 2021 · 1,029 followers View post →

Jeff Wintersinger

@jwintersinger · X

@nathanseligson In general, consensus strategies are good, but practically, they're challenging. In the PCAWG paper you mentioned (https://t.co/HAuFXcJceU), we invested an enormous amount of effort in developing consensus approaches.

Apr 8, 2021 · 1,029 followers View post →

Dr. Ceri Fielding

@CeriFielding · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 8, 2021 · 41 shares · 1,320 followers View post →

Javier Oliver, PhD

@javiom · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/Jm9JxvalFN

Apr 8, 2021 · 199 followers View post →

Inti De La Rosa Velazquez

@IntiOmics · X

Apr 8, 2021 · 1 like · 1,399 followers View post →

Yaron Einhorn

@yaronoox · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/ekWXDf8E7D

Apr 8, 2021 · 23 followers View post →

Michael Buratovich

@MichaelBuratovi · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,168 followers View post →

Maia

@angeliquedeberg · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 2,961 followers View post →

Keisuke Kataoka Laboratory（片岡圭亮研究室）

@kataoka_lab · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 876 followers View post →

Brenda Schory

@BrendaSchory · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 2,088 followers View post →

د. عبدالمحسن بن غيث الحجيلي الحربي

@ABDLM0HSN · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 205 followers View post →

Xinwei Sher

@Sher_Xinwei · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 9 followers View post →

Giorgio Seano

@GiorgioSeano · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,198 followers View post →

Eric Minwei Liu

@EricM_Liu · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 932 followers View post →

Florian Halbritter

@cancerbits · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 296 followers View post →

William B. Coleman, PhD

@WBColeman15 · X

RT @Rndubois: Characterizing genetic #intra-#tumor #heterogeneity across 2,658 human #cancer #genomes: https://t.co/u4e78Qtc1r

Apr 7, 2021 · 1 share · 653 followers View post →

Martin Cornillet, PhD

@MartinCornillet · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 207 followers View post →

Sandy Anderson

@ara_anderson · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 5,371 followers View post →

Olga Francino

@olga_francino · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,253 followers View post →

Alvaro

@AlvaroM_ENG · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,978 followers View post →

Dr Anthony Martin

@AMAinsight · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes: Cell https://t.co/Y3XZFYuEgE

Apr 7, 2021 · 913 followers View post →

@EstebanezLab

@Eva46653369 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 2,654 followers View post →

Tom Conklin

@Tom_Conklin_ · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 171 followers View post →

Matteo Morotti

@MMorotti · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 488 followers View post →

Eytan Ruppin, MD, PhD

@EytanRuppin · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 5,064 followers View post →

Kasit Chatsirisupachai

@KasitC10 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 338 followers View post →

Waleed Al Amri

@wlamri · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 257 followers View post →

Ching-Hsien Chen Lab-UC Davis

@ChenLabUCDavis1 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 19 followers View post →

hongtuzhu1

@hongtuzhu1 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,175 followers View post →

Ray DuBois, MD, PhD

@Rndubois · X

Characterizing genetic #intra-#tumor #heterogeneity across 2,658 human #cancer #genomes: https://t.co/u4e78Qtc1r

Apr 7, 2021 · 1 share · 5,573 followers View post →

Eddie Rashan

@EdreesRashan · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 953 followers View post →

David Russler-Germain, MD/PhD

@dgermain21 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 3,665 followers View post →

Francesco Maura

@FrancescoMaura4 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,560 followers View post →

Heer Lab

@Heer_Lab · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,615 followers View post →

Lasse Sommer Kristensen

@Kristensen_Lab · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 352 followers View post →

Yuki Saito

@YukiSaito_MDPhD · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 221 followers View post →

Lu Wei

@greenygreen1112 · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 38 followers View post →

Quaid Morris

@quaidmorris · X

RT @AmitDeshwar: After a long, long journey, our paper characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes i…

Apr 7, 2021 · 2 shares · 4,437 followers View post →

Scallion

@RemakeSystems · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 122 followers View post →

Kerstin Haase

@HaaseKerstin · X

RT @AmitDeshwar: After a long, long journey, our paper characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes i…

Apr 7, 2021 · 2 shares · 247 followers View post →

Amit Deshwar

@AmitDeshwar · X

Apr 7, 2021 · 12 likes · 2 shares · 627 followers View post →

Emre Kocakavuk, MD, PhD

@ekocakavuk · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 933 followers View post →

venu☘️

@itsvenu_ · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 677 followers View post →

Advanced Research Alliance

@ASKaboutARA · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 204 followers View post →

James Black

@jrm_black · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 918 followers View post →

lmmortal Seti

@angelseti · X

RT @CellCellPress: New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.…

Apr 7, 2021 · 41 shares · 1,696 followers View post →

Mwinde Mwolilo

@ThinkerTweet22 · X

https://t.co/i709GMsbMw

Apr 7, 2021 · 1 like · 371 followers View post →

Cell

@CellCellPress · X

New Resource now online! Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes - https://t.co/htQIbmOmyS

Apr 7, 2021 · 128 likes · 41 shares · 263,142 followers View post →

hongtuzhu1

@hongtuzhu1 · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes https://t.co/G52J9P9erR

Sep 23, 2020 · 1,175 followers View post →

Jason H. Moore, PhD

@moorejh · X

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes https://t.co/LLWdo1oiil #cancer #genomics HT @AlbertVilella https://t.co/pfgyq6d5J8

Apr 22, 2020 · 34,217 followers View post →

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Characterizing Intra-Tumor Heterogeneity in Cancer Genomes

Genetic Intra-Tumor Heterogeneity in Cancer Development