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Nat Methods May 2023 PMID 37012480

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics.

R Gray Huffman, Andrew Leduc, Christoph Wichmann, Marco Di Gioia, Francesco Borriello, Harrison Specht, Jason Derks, Saad Khan, Luke Khoury, Edward Emmott, Aleksandra A Petelski, David H Perlman, Jürgen Cox, Ivan Zanoni, Nikolai Slavov

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Mentions

49
Peak: 35 in Apr 2023
across 5 sources since Apr 2023

Extended reach

76,926
potential audience

Total likes

197

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6,345

Mentions per month

Apr 2023 – Nov 2025

Where it's discussed

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AI synopsis

What people are saying

Several discussions celebrate the article's breakthrough in increasing data depth, with phrases like 'excited for collaboration' and 'revolutionizes proteomics,' demonstrating high interest and engagement. The tone reflects excitement about the method's potential to significantly advance the field, suggesting a consensus on its high impact and importance.

AgreementStrong agreement

Most discussions strongly endorse the significance of the research, emphasizing its potential to advance proteomics capabilities.

InterestHigh interest

The posts express high interest by highlighting collaborations, new methodologies, and excitement about the technological advances in single-cell proteomics.

EngagementHigh engagement

Participants actively discuss specifics like increased proteome depth and reduced analysis time, indicating deep engagement with the topic.

ImpactHigh impact

The majority of posts suggest that this method could be transformative for biological research, emphasizing its broad implications and practical applications.

Abstract in brief

  • Prioritized mass spectrometry (pSCoPE) enhances single-cell proteomics by increasing data sensitivity, completeness, and depth, allowing for more precise analysis of proteins and their modifications.
  • This method analyzes thousands of selected peptides across individual cells, doubling the amount of measurable proteome data and enabling detailed insights into protein variation, functional relationships, and enzymatic activities in different treatment conditions.
  • pSCoPE is freely accessible, applicable to various biological studies, and helps researchers focus on proteins of interest without compromising proteome coverage.]
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Top posts

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Ivan Zanoni
@Lo_Zanzi · X

Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase proteome depth, reducing time, in our beloved #macrophages! We identified endocytic & proteolitic differences at the single cell lvl! https://t.co/efCvx6CY4N

Apr 3, 2023 · 72 likes · 15 shares · 9,074 followers View post →
BioDecoded
@BioDecoded · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics | Nature Methods https://t.co/QsTf1dlU2k #proteomics https://t.co/5mopvhIZFx

Apr 26, 2023 · 12 likes · 3 shares · 8,905 followers View post →
Tatsuya Nobori
@nobolly · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/BgvDkWEGRa

Apr 3, 2023 · 9 likes · 3 shares · 8,193 followers View post →
Northeastern University Bioengineering
@NUBioE1 · X

Our BioE Professors are always keeping busy! Here are some recent articles: @BajpayeeLab @ChenzhenZhang - https://t.co/KKyWzXaAIJ @slavovLab - https://t.co/JLqnKLZA96 Kiran Vanaja - https://t.co/1eNv4z7f8d & https://t.co/49PaUHfHOv Rai Winslow - https://t.co/P867bMfct6 https://t.co/4nPWjWOlmg

Apr 14, 2023 · 7 likes · 2 shares · 612 followers View post →
Pastel BioScience
@PastelBio · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics | https://t.co/D7y4dFMOBz #proteomics https://t.co/UZaVAxBcsH

Apr 6, 2023 · 5 likes · 5,376 followers View post →
Kermit Murray
@kermitmurray · X

(Nature MS) Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/Rc5ZoNmBpg (RSS) #nature #MassSpec https://t.co/r0tN7fO3PV

Apr 3, 2023 · 5 likes · 1 share · 1,968 followers View post →

All mentions

Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/Iv0aK4P0M0

Oct 16, 2024 · 2,065 followers View post →
Chenzhen Zhang
@ChenzhenZhang · X

RT @NUBioE1: Our BioE Professors are always keeping busy! Here are some recent articles: @BajpayeeLab @ChenzhenZhang - https://t.co/KKyWzX…

Jun 5, 2023 · 2 shares · 11 followers View post →
Dany Domínguez Pérez
@danydguezperez · X

RT @BioDecoded: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics | Nature Met…

Apr 26, 2023 · 3 shares · 282 followers View post →
Prasath Lab CCHMC
@PrasathLab · X

RT @BioDecoded: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics | Nature Met…

Apr 26, 2023 · 3 shares · 1,088 followers View post →
Yang Fang
@xiaoxiaoyangs · X

RT @BioDecoded: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics | Nature Met…

Apr 26, 2023 · 3 shares · 24 followers View post →
BioDecoded
@BioDecoded · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics | Nature Methods https://t.co/QsTf1dlU2k #proteomics https://t.co/5mopvhIZFx

Apr 26, 2023 · 12 likes · 3 shares · 8,905 followers View post →
Roux Institute at Northeastern
@RouxInstitute · X

RT @NUBioE1: Our BioE Professors are always keeping busy! Here are some recent articles: @BajpayeeLab @ChenzhenZhang - https://t.co/KKyWzX…

Apr 14, 2023 · 2 shares · 1,503 followers View post →
Northeastern University Bioengineering
@NUBioE1 · X

Our BioE Professors are always keeping busy! Here are some recent articles: @BajpayeeLab @ChenzhenZhang - https://t.co/KKyWzXaAIJ @slavovLab - https://t.co/JLqnKLZA96 Kiran Vanaja - https://t.co/1eNv4z7f8d & https://t.co/49PaUHfHOv Rai Winslow - https://t.co/P867bMfct6 https://t.co/4nPWjWOlmg

Apr 14, 2023 · 7 likes · 2 shares · 612 followers View post →
Ikemen
@HandsomeKinoko · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics #maskotlib #note https://t.co/V0eH7VueiY

Apr 9, 2023 · 1 like · 1,276 followers View post →
Pastel BioScience
@PastelBio · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics | https://t.co/D7y4dFMOBz #proteomics https://t.co/UZaVAxBcsH

Apr 6, 2023 · 5 likes · 5,376 followers View post →
Bharath Kumar Raghuraman
@rbharathkumar91 · X

RT @kermitmurray: (Nature MS) Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomic…

Apr 5, 2023 · 1 share · 294 followers View post →
Andréa Rocha
@rochaandreal · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 404 followers View post →
Agostinho Carvalho
@carvalho_ago · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 621 followers View post →
Ankit Singla
@In_AnkitSingla · X

RT @nobolly: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/Bg…

Apr 4, 2023 · 3 shares · 1,488 followers View post →
Mark Borris Aldonza (@precursorcell.bsky.social
@PrecursorCell · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 1,384 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @realBioMassSpec: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics #NatMet…

Apr 4, 2023 · 2 shares · 566 followers View post →
Dapeng Chen
@CharlieSaid3 · X

RT @realBioMassSpec: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics #NatMet…

Apr 4, 2023 · 2 shares · 20 followers View post →
Pisigomet
@pisigomet · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 292 followers View post →
BioMassSpec
@realBioMassSpec · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics #NatMethods https://t.co/Rggkfq4Z06

Apr 4, 2023 · 2 likes · 2 shares · 5,994 followers View post →
Alice Bertocchi
@Alice18373761 · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 123 followers View post →
Kurian Lab
@KurianLab · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 2,691 followers View post →
Endocryne Papers
@Endocryne_reads · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/m44ySBFC8D

Apr 4, 2023 · 21 followers View post →
Lum Lab
@lum_lab · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 1,207 followers View post →
Dufourlab
@dufourlab · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 4, 2023 · 15 shares · 1,176 followers View post →
Aldo Ummarino
@AUmmarino · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 3, 2023 · 15 shares · 114 followers View post →
Kermit Murray
@kermitmurray · X

(Nature MS) Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/Rc5ZoNmBpg (RSS) #nature #MassSpec https://t.co/r0tN7fO3PV

Apr 3, 2023 · 5 likes · 1 share · 1,968 followers View post →
DTHSTR
@CDADeathStar · X

Prioritized mass spectrometry increases the depth sensitivity and data completeness of null https://t.co/CpmQ8h67kU #DTHSTR

Apr 3, 2023 · 113 followers View post →
Tristram Ryan
@tristramryan · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 3, 2023 · 15 shares · 320 followers View post →
Marco Di Gioia
@Marco_Di_Gioia · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 3, 2023 · 15 shares · 109 followers View post →
lbgbox
@lbgbox · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 3, 2023 · 15 shares · 51 followers View post →
Bozeng Tang
@BozengTang · X

RT @nobolly: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/Bg…

Apr 3, 2023 · 3 shares · 1,093 followers View post →
T.T. Cooper
@TTCooper_PhD · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 3, 2023 · 15 shares · 813 followers View post →
Jason Derks
@_JasonDerks · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 3, 2023 · 15 shares · 256 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @Lo_Zanzi: Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase pro…

Apr 3, 2023 · 15 shares · 8,157 followers View post →
Ivan Zanoni
@Lo_Zanzi · X

Excited for our collaboration @naturemethods with @slavov_n: a new prioritized #SingleCell #MassSpec approach to increase proteome depth, reducing time, in our beloved #macrophages! We identified endocytic & proteolitic differences at the single cell lvl! https://t.co/efCvx6CY4N

Apr 3, 2023 · 72 likes · 15 shares · 9,074 followers View post →
Hiro Nakagami 中神 弘史
@Grandpa_Hiro · X

RT @nobolly: Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/Bg…

Apr 3, 2023 · 3 shares · 2,342 followers View post →
Tatsuya Nobori
@nobolly · X

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics https://t.co/BgvDkWEGRa

Apr 3, 2023 · 9 likes · 3 shares · 8,193 followers View post →