Nat Commun May 2023 PMID 37160865

Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.

Arthur Neuberger, Yury A Trofimov, Maria V Yelshanskaya, Kirill D Nadezhdin, Nikolay A Krylov, Roman G Efremov, Alexander I Sobolevsky

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Mentions

10
Peak: 9 in May 2023
across 2 sources since May 2023

Extended reach

15,996
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Total likes

34

Video views

17

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter9 posts
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AI synopsis

What people are saying

The overall discussion reflects a neutral stance, with participants sharing basic acknowledgments and tagging each other for attention, such as @arthurCantab and @kirillnadezhdi2, indicating mild interest. The tone and wording suggest they recognize the scientific relevance but do not delve into detailed implications or critique.

AgreementNeither agree nor disagree

The discussion includes members who acknowledge the publication but do not express strong opinions of support or disagreement.

InterestModerate interest

Participants demonstrate some curiosity, especially regarding potential therapeutic implications, but overall engagement remains modest.

EngagementNeutral engagement

The exchange is somewhat superficial with mentions of the study's subject matter without deep analysis or critical discussion.

ImpactNeutral impact

The comments have limited influence on shaping opinions or encouraging widespread consideration of the findings.

Abstract in brief

  • The study reveals that the natural plant compound genistein binds inside the TRPV6 channel, blocking calcium flow and altering its shape to prevent it from opening.
  • Using techniques like cryo-electron microscopy, electrophysiology, and computer simulations, researchers show genistein causes the channel to close by making specific structural changes.
  • This new understanding of how genistein inhibits TRPV6 provides valuable insights for designing more effective drugs to target cancer-related cell growth.]

Top posts

Most liked on X and Bluesky
Alexander Sobolevsky
@AlexanderSobol6 · X

Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzoR8C @arthurCantab @kirillnadezhdi2 @MariaKarela3

May 9, 2023 · 34 likes · 7 shares · 1,718 followers View post →
Kato
@oxkawaka · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 5,816 followers View post →
Kato
@oxkawaka · X

Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein 2日連続で出してきた、すげぇなこのグループ https://t.co/xlCA2Orvib https://t.co/eJJAsBuVwO

May 9, 2023 · 1 share · 5,816 followers View post →
Luis O. Romero
@LuisOctavioR · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 1,054 followers View post →
Ojiman
@Ojiman_VR · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 564 followers View post →
Slav Bagriantsev
@SlavBagria · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 427 followers View post →

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Maria Karela
@MariaKarela3 · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 16, 2023 · 7 shares · 63 followers View post →
Alessandra fioriopla
@AFioriopla · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 11, 2023 · 7 shares · 327 followers View post →
Slav Bagriantsev
@SlavBagria · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 427 followers View post →
Luis O. Romero
@LuisOctavioR · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 1,054 followers View post →
Ojiman
@Ojiman_VR · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 564 followers View post →
Kato
@oxkawaka · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 5,816 followers View post →
Kato
@oxkawaka · X

Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein 2日連続で出してきた、すげぇなこのグループ https://t.co/xlCA2Orvib https://t.co/eJJAsBuVwO

May 9, 2023 · 1 share · 5,816 followers View post →
Kirill Nadezhdin
@knadezhdinPhD · X

RT @AlexanderSobol6: Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzo…

May 9, 2023 · 7 shares · 81 followers View post →
Alexander Sobolevsky
@AlexanderSobol6 · X

Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein https://t.co/MWrbwzoR8C @arthurCantab @kirillnadezhdi2 @MariaKarela3

May 9, 2023 · 34 likes · 7 shares · 1,718 followers View post →