Plasma proteomics links brain and immune system aging with healthspan and longevity.

Hamilton Se-Hwee Oh, Yann Le Guen, Nimrod Rappoport, Deniz Yagmur Urey, Amelia Farinas, Jarod Rutledge, Divya Channappa, Anthony D Wagner, Elizabeth Mormino, Anne Brunet, Michael D Greicius, Tony Wyss-Coray

August 2025 Nat Med

Synopsis of Social media discussions

The discussions collectively praise the study’s innovative approach of using plasma proteins to assess organ and systemic aging, with examples like mentions of its role in predicting disease and extending lifespan. The tone and emphasis on applications, such as early detection and intervention, underline the perceived significance and high interest among participants.

A
Agreement
 Strong agreement

Most discussions emphasize the significance of plasma proteomics in understanding aging and longevity, showing strong support for the study’s implications.

I
Interest
 High level of interest

Participants demonstrate high interest by referencing detailed findings, potential applications, and facilitating further reading and research connections.

E
Engagement
 Moderate level of engagement

Comments include references to specific methods, the role of the brain and immune system in aging, and future implications, indicating active engagement.

I
Impact
 High level of impact

Several posts highlight the importance of this research for early detection, targeted interventions, and its potential to influence aging and healthcare strategies, reflecting high perceived impact.

Social Mentions

YouTube

3 Videos

Bluesky

9 Posts

Facebook

6 Posts

Twitter

116 Posts

Blogs

6 Articles

News

117 Articles

Metrics

Video Views

18

Total Likes

404

Extended Reach

1,103,971

Social Features

257

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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July 11, 2025

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Understanding Plasma Proteomics in Aging and Longevity Research

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Plasma proteins from specific organs can assess organ age and predict mortality. This study analyzed data from nearly 45,000 individuals to estimate organ biological ages and their links to healthspan and longevity.

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July 10, 2025

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Plasma Proteins Link Organ Aging to Disease and Longevity Evidence

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Plasma proteins from specific organs can assess organ age and predict mortality. Researchers analyzed plasma proteomics data from nearly 45,000 individuals to estimate aging of 11 organs, revealing links to diseases like heart failure and diabetes, and highlighting implications for healthspan and longevity.

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July 14, 2025

0 views

  • Agingdoc
    @agingdoc1 (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/sNQo5QHvZb
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    October 12, 2025

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  • Martinez Laurent
    @LiMitAging (Twitter)

    RT @INSPIREPlatfor1: Organ age and mortality in "Plasma proteomics links brain and immune system aging with healthspan and longevity." http…
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    October 7, 2025

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  • INSPIRE Platform - IHU HealthAge
    @INSPIREPlatfor1 (Twitter)

    Organ age and mortality in "Plasma proteomics links brain and immune system aging with healthspan and longevity." https://t.co/Czy9zpbsv7 @brunovellas @I2mcT @LiMitAging
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    October 7, 2025

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  • Masaaki Yokoyama
    @MYOKOYAMA11 (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/SpiB0bPiwV
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    October 4, 2025

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  • 竹内 康正 ❤️ Yasumasa Takeuchi
    @zephyorg (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
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    September 29, 2025

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  • SNZK
    @shinopp (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
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    September 27, 2025

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  • 芋山芋太郎
    @rakk_1221 (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
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    September 27, 2025

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  • negikafun tama
    @negikafun (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
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    September 27, 2025

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  • 備忘録
    @bibourokuabc (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
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    September 27, 2025

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  • Nature Japan
    @NatureJapan (Twitter)

    Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/9ngqEALvIV #オープンアクセス @Stanford https://t.co/h5WHwt4TpD https://t.co/LKtraGEEvI
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    September 27, 2025

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  • cloudameoba
    @cloudameoba (Twitter)

    RT @ShihchengGuo: Plasma proteomics from 44,498 UK Biobank individuals reveal that organ ages, derived from 2,916 proteins, are influenced…
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    September 22, 2025

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  • Aubrai
    @Aubrai_ (Twitter)

    @AnotherDNF2 @BioProtocol
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    September 21, 2025

  • Shicheng Guo
    @ShihchengGuo (Twitter)

    Plasma proteomics from 44,498 UK Biobank individuals reveal that organ ages, derived from 2,916 proteins, are influenced by lifestyle and can predict disease onset. #AgingResearch PMID:40634782, Nat Med 2025, @NatureMedicine @Stanford https://t.co/7zLKlWHXsP #AI #Pharma #BioMed
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    September 21, 2025

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  • Krzysztof Potempa
    @BRAINCURES (Twitter)

    @ARDD_Meeting @wysscoray @NatureMedicine Tweetorial from the first author of Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/wmey2gNbxz. Great further reading for #ARDD2025 conference attendees and beyond https://t.co/3MaiBxiS7l
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    August 30, 2025

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  • Krzysztof Potempa
    @BRAINCURES (Twitter)

    @ARDD_Meeting Brain age is captured in circulation by proteins of the neuronal, oligodendroglial and synaptic extracellular matrix—highlight from “Plasma proteomics links brain and immune system aging with healthspan and longevity” from @wysscoray’s lab @NatureMedicine https://t.co/wmey2gNbxz https://t.co/METCrDo5io
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    August 30, 2025

  • Ma*do final season
    @halocito (Twitter)

    RT @MariAngelesMoro: Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/ftZ…
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    August 26, 2025

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  • Christophe Ebener
    @Ch_Ebener (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/BFaSldQlss
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    August 25, 2025

  • Marina García Macia
    @Juanaloca2002 (Twitter)

    RT @MariAngelesMoro: Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/ftZ…
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    August 25, 2025

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  • María A. Moro
    @MariAngelesMoro (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/ftZIgYhFBh
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    August 25, 2025

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  • Shiri Gur-Cohen
    @ShiriGurCohen (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/UAVvxpqxSZ
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    August 24, 2025

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  • Matheus Fragas
    @fragasmg.bsky.social (Bluesky)

    Plasma proteomics links brain and immune system aging with healthspan and longevity www.nature.com/articles/s41...
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    August 24, 2025

  • Cristina Dragani
    @CristinaDragani (Twitter)

    More aged organs meant higher mortality risk. Youthful brains + immune systems were tied to the longest lifespans. Plasma proteins could become a key tool for early disease detection and longevity interventions. Full study: https://t.co/5LSqsd1bIq #aging #longevity https://t.co/Qin33GAwc3
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    August 12, 2025

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  • 竹内 康正 ❤️ Yasumasa Takeuchi
    @zephyorg (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
    view full post

    August 8, 2025

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  • 備忘録
    @bibourokuabc (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
    view full post

    August 8, 2025

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  • .Act3
    @dot_actotion (Twitter)

    RT @NatureJapan: Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics link…
    view full post

    August 8, 2025

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  • Nature Japan
    @NatureJapan (Twitter)

    Hamilton Se-Hwee Oh、Tony Wyss-Corayらのプラズマプロテオミクスによる脳と免疫系の老化と健康寿命および長寿の関連に関する@NatureMedicine #OA #論文 Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/9ngqEALvIV #オープンアクセス @Stanford https://t.co/tSxPap3hA7
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    August 8, 2025

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  • Kat Fu, M.S., M.S.
    @thekatfu (Twitter)

    Oh, https://t.co/2mzOvMyHSh., Le Guen, Y., Rappoport, N. et al. Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med (2025).
    view full post

    August 6, 2025

  • Agingdoc
    @agingdoc1 (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity
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    August 6, 2025

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  • HUPO Human Brain Proteome Project (HBPP)
    @BrainProteomics (Twitter)

    RT @WisdomFlowX: Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/TCFD36g…
    view full post

    August 6, 2025

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  • BioNow
    @bionowmc (Twitter)

    Your organs age at different speeds. This study used 3,000 blood proteins to track the biological age of the brain, liver, heart, and more. Some people’s organs were decades older—or younger—than they looked. Nature Medicine, 2025
    view full post

    July 31, 2025

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  • WisdomFlowX
    @WisdomFlowX (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/TCFD36gpjG
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    July 30, 2025

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  • Stacey Finn
    @StaceyFinn12 (Twitter)

    RT @agingdoc1: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/UrxYgM6KtH https://t.co/w0…
    view full post

    July 25, 2025

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  • Agingdoc
    @agingdoc1 (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/UrxYgM6KtH https://t.co/w0hITmyHB2
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    July 25, 2025

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  • Janel Le Belle
    @janellebelle.bsky.social (Bluesky)

    This study has a number of very interesting results. More than any other factor keeping your brain healthy and “young” results in greater lifespan. Nature Medicine: Plasma proteomics links brain and immune system aging with healthspan and longevity www.nature.com/articles/s41...
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    July 24, 2025

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  • Kat Fu, M.S., M.S.
    @thekatfu (Twitter)

    Oh, https://t.co/2mzOvMyHSh., Le Guen, Y., Rappoport, N. et al. Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med (2025).
    view full post

    July 20, 2025

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  • Pon｜食と健康
    @PonNutr (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity. Nature medicine, 10.1038/s41591-025-03798-1. https://t.co/Dv1fMmVvqm
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    July 19, 2025

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  • Sibz
    @SibzSiba (Twitter)

    RT @NeuroscienceNew: “Plasma proteomics links brain and immune system aging with healthspan and longevity” by Tony Wyss-Coray, et al. Natur…
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    July 19, 2025

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  • BreakthroughMedicine&AdvancedResearchTools
    @JayChance12 (Twitter)

    RT @LifeboatHQ: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/qT2hVD5qgx
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    July 18, 2025

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  • Lifeboat Foundation
    @LifeboatHQ (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/qT2hVD5qgx
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    July 18, 2025

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  • Barry Bunin
    @barrybunin (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/VSZvHQCtk0
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    July 17, 2025

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  • chud Mc Chudd
    @Dummyacct407 (Twitter)

    @bryan_johnson new article in Nature: Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine suggests that (a) brain and (b) immune system the best predictors of longevity.
    view full post

    July 16, 2025

  • Johns Hopkins Frailty Science #FrailtyFighter
    @FrailtyScience (Twitter)

    RT @brunovellas: Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/L3op5D8…
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    July 16, 2025

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  • Carmen De Miguel, PhD, MS, FAHA
    @Carmendemigue12 (Twitter)

    RT @Research_Bites: Researchers have found that plasma proteins can indicate organ age and future disease risk. Aged organs raise mortality…
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    July 16, 2025

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  • Lum Lab
    @lum_lab (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    July 16, 2025

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  • Research Bites
    @Research_Bites (Twitter)

    Researchers have found that plasma proteins can indicate organ age and future disease risk. Aged organs raise mortality risk, while younger brains and immune systems enhance longevity. - Read more: https://t.co/IOcTcpCzD6
    view full post

    July 15, 2025

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  • Research Bites
    @Research_Bites (Twitter)

    Research shows that plasma proteins can predict organ age and future disease risk. An aged brain increases Alzheimer's risk, while youthful organs boost longevity. Monitoring these proteins could aid health. - Read more: https://t.co/IOcTcpCzD6
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    July 15, 2025

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  • Johan Van Weyenbergh
    @johanvawe (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    July 15, 2025

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  • Jang Hyun (Jay) Park
    @janghyun_park_ (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    July 15, 2025

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  • Joanna Ward
    @jo_ward08 (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Lucas Jordie
    @NerdyHealthLJ (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    July 15, 2025

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  • Casey Davis
    @CaseyHealthC (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Luigi F. Iannone
    @Luigi_Ian_ (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Dr. Gennadi Glinsky, MD, Ph.D.
    @gglinskii (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/qqasK4lePD
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    July 15, 2025

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  • Dr Alexandra Harvey
    @tealgecko (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    @ScienceKyle (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    July 14, 2025

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  • Richard S
    @Richard01173388 (Twitter)

    RT @Richard01173388: @NatureMedicine Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/54Tto…
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    July 14, 2025

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  • Richard S
    @Richard01173388 (Twitter)

    @NatureMedicine Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/54TtoBgoWO Researchers at @Stanford have developed a new tool that can compute the “biological age” of human organs by processing a single vial of blood.
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    July 14, 2025

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  • CopperKettle
    @Artyom_Yekat (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Dr. Ceri Fielding
    @CeriFielding (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Archana Tomar, PhD
    @Arch_Epicomp (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Md. Naiem Hossain
    @Naiem2217 (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Christian LLC
    @lacks22 (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    @raan62 (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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    @zulumz (Twitter)

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    @seraphus7 (Twitter)

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  • Químics de Catalunya
    @quimics (Twitter)

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    @Orange_Atomique (Twitter)

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    July 14, 2025

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    @dontavo66 (Twitter)

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    @iArmandoVBanned (Twitter)

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    @bibourokuabc (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Kate M.
    @KateM000000 (Twitter)

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  • Nat Vilor-Tejedor
    @natvilortejedor (Twitter)

    RT @AgingBiology: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Maxim Pozdorovkin
    @maximpoz (Twitter)

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  • Nathalia Le Hen
    @NathaliaLeHen (Twitter)

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  • Aging Science News
    @agingbiology.bsky.social (Bluesky)

    Plasma proteomics links brain and immune system aging with healthspan and longevity www.nature.com/articles/s41...
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  • Aging Science News
    @AgingBiology (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/QYwrMaL0RA
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  • Roger Blackwell
    @rogerablackwell (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/7MnToZHBjn
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    July 12, 2025

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  • ARTSTRADA MAGAZINE
    @artstradamagazine.bsky.social (Bluesky)

    Plasma proteomics links brain and immune system aging with healthspan and longevity www.nature.com/articles/s41...
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    July 11, 2025

  • tatzanx
    @tatzanx.bsky.social (Bluesky)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine www.nature.com/articles/s41...
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    July 11, 2025

  • Shane Worth @tatzanx@universeodon.com
    @tatzanx (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity | Nature Medicine https://t.co/rEvL4JyusJ
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    July 11, 2025

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  • Juan Fafián-Labora
    @fafian_juan (Twitter)

    RT @Pluchinolab: Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/7sFcnikLXN
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    July 11, 2025

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  • Ilse Daehn, PhD
    @ilse_daehn (Twitter)

    RT @KSusztak: Plasma proteomics links brain and immune system aging with healthspan and longevity | ⁦@NatureMedicine⁩ https://t.co/PuPlmeJ…
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    July 11, 2025

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  • RR BaligaMD, Professor & Cardiologist
    @RRBaligaMD (Twitter)

    Dr RR Baliga’s “Got Knowledge Doc?” Podkast Longevity’s Guardians?: The Brain and Immune System Duo https://t.co/S8T8UpAIFd via @YouTube #MedEd @NatureMedicine @NYTHealth @WSJhealth @doximity @AmerMedicalAssn
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  • PedNephJouhou
    @PNJouhou (Twitter)

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    July 11, 2025

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  • Dr. Gennadi Glinsky, MD, Ph.D.
    @gglinskii (Twitter)

    Plasma proteomics links brain and immune system aging with healthspan and longevity https://t.co/qqasK4lMFb
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Abstract Synopsis

  • Plasma proteins from specific organs can assess organ age and predict mortality, but their effectiveness in disease forecasting is still uncertain.
  • Researchers analyzed plasma proteomics data from nearly 45,000 individuals to estimate the biological age of 11 organs, revealing that organ age is influenced by lifestyle and medications, and linked to diseases like heart failure and diabetes.
  • An older brain significantly increases the risk of Alzheimer's disease, while younger brains and immune systems correlate with reduced mortality risk, suggesting plasma proteins could be useful for monitoring organ health and targeting longevity interventions.