Publications by authors named "Ajit Dash"

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Safety, Pharmacokinetics, and Immunogenicity of Astegolimab, an Anti-ST2 Monoclonal Antibody, in Randomized, Phase I Clinical Studies.
Wenhui Zhang, Dorothy Cheung, Alice Fong, Logan Brooks, Michele A Grimbaldeston, Ajit Dash

Clin Transl Sci· October 2025

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Safety and tolerability of astegolimab, an anti-ST2 monoclonal antibody: a narrative review.
Steven G Kelsen, Marcus Maurer, Michael Waters, Ajit Dash, Alice Fong

Respir Res· October 2025

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The Impact of COVID-19 and COVID-19 Vaccination on Detection, Assessment, and Management of Suspected Acute Drug-Induced Liver Injury Occurring during Clinical Trials: Consensus Recommendations from the IQ DILI Initiative.
Melissa Palmer, Daniel Seekins, Mark Avigan, John Marcinak, Don C Rockey, Ajit Dash

Drug Saf· August 2025

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A Randomized Phase II Study of Efmarodocokin Alfa, an interleukin-22 Agonist, Versus Vedolizumab in Patients With Ulcerative Colitis.
Silvio Danese, Michael E Rothenberg, Jeremy J Lim, Han Ting Ding, Jacqueline M McBride, Ajit Dash

Clin Gastroenterol Hepatol· July 2025

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Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma.
Horace Rhee, Lindsay M Henderson, Rebecca N Bauer, Kit Wong, Tracy L Staton, Ajit Dash

Allergy· November 2024

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Simulation-based evaluation of personalized dosing approaches for anti-FGFR/KLB bispecific antibody fazpilodemab.
Kenta Yoshida, Victor Poon, Ajit Dash, Rebecca Kunder, Leslie Chinn

CPT Pharmacometrics Syst Pharmacol· April 2024

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Fibroblast growth factor receptor 1/Klothoβ agonist BFKB8488A improves lipids and liver health markers in patients with diabetes or NAFLD: A phase 1b randomized trial.
Chin Wong, Ajit Dash, Jill Fredrickson, Nicholas Lewin-Koh, Shan Chen

Hepatology· September 2023

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Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis.
Frank Wagner, John C Mansfield, Annemarie N Lekkerkerker, Yehong Wang, Mary Keir, Ajit Dash

Gut· August 2023

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Phase 2 randomized clinical trial of astegolimab in patients with moderate to severe atopic dermatitis.
Marcus Maurer, Dorothy S Cheung, Wiebke Theess, Xiaoying Yang, Michael Dolton, Ajit Dash

J Allergy Clin Immunol· December 2022

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Optical Microscope Based Universal Parameter for Identifying Layer Number in Two-Dimensional Materials.
Mainak Mondal, Ajit K Dash, Akshay Singh

ACS Nano· September 2022

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Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial.
Steven G Kelsen, Ioana O Agache, Weily Soong, Elliot Israel, Geoffrey L Chupp, Ajit Dash

J Allergy Clin Immunol· September 2021

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Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepatitis and Adults with Cirrhosis Secondary to Hepatitis B, C and Nonalcoholic Steatohepatitis.
William R Treem, Melissa Palmer, Isabelle Lonjon-Domanec, Daniel Seekins, Lara Dimick-Santos, Ajit Dash

Drug Saf· February 2021

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Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development.
Sharin E Roth, Mark I Avigan, David Bourdet, David Brott, Rachel Church, Ajit Dash

Clin Pharmacol Ther· February 2020

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Non-alcoholic fatty liver disease (NAFLD) models in drug discovery.
Banumathi K Cole, Ryan E Feaver, Brian R Wamhoff, Ajit Dash

Expert Opin Drug Discov· February 2018

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Systems biology for organotypic cell cultures.
Sonia Grego, Edward R Dougherty, Francis J Alexander, Scott S Auerbach, Brian R Berridge, Ajit Dash

ALTEX· October 2017

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Drug-induced steatohepatitis.
Ajit Dash, Robert A Figler, Arun J Sanyal, Brian R Wamhoff

Expert Opin Drug Metab Toxicol· February 2017

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Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis.
Ryan E Feaver, Banumathi K Cole, Mark J Lawson, Stephen A Hoang, Svetlana Marukian, Ajit Dash

JCI Insight· December 2016

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Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.
Ylva Terelius, Robert A Figler, Svetlana Marukian, Maria S Collado, Mark J Lawson, Ajit Dash

Chem Biol Interact· August 2016

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Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes.
Kimberly A Chapman, Maria S Collado, Robert A Figler, Stephen A Hoang, Allison J Armstrong, Ajit Dash

Mol Genet Metab· March 2016

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One-Pot Fabrication of RGO-Ag3 VO4 Nanocomposites by in situ Photoreduction using Different Sacrificial Agents: High Selectivity Toward Catechol Synthesis and Photodegradation Ability.
Dipti P Das, Alaka Samal, Jasobanta Das, Ajit Dash, Hariom Gupta

Photochem Photobiol· January 2014

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Organotypic systems in drug metabolism and toxicity: challenges and opportunities.
Ajit Dash, Brett R Blackman, Brian R Wamhoff

Expert Opin Drug Metab Toxicol· August 2012

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Proteins modified by the lipid peroxidation aldehyde 9,12-dioxo-10(E)-dodecenoic acid in MCF7 breast cancer cells.
Peter G Slade, Michelle V Williams, Viral Brahmbhatt, Ajit Dash, John S Wishnok

Chem Res Toxicol· March 2010

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Perfused multiwell plate for 3D liver tissue engineering.
Karel Domansky, Walker Inman, James Serdy, Ajit Dash, Matthew H M Lim

Lab Chip· January 2010

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Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression.
Clayton Yates, Chistopher R Shepard, Glenn Papworth, Ajit Dash, Donna Beer Stolz

Adv Cancer Res· October 2009

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Liver tissue engineering in the evaluation of drug safety.
Ajit Dash, Walker Inman, Keith Hoffmaster, Samantha Sevidal, Joan Kelly

Expert Opin Drug Metab Toxicol· October 2009

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