Publications by authors named "Alan Fairlamb"

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Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes.
Han B Ong, Susan Wyllie, Alan H Fairlamb

PLoS Negl Trop Dis· July 2025

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Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.
Lindsay B Tulloch, Michele Tinti, Richard J Wall, Stefan K Weidt, Victoriano Corpas-Lopez, Alan H Fairlamb

PLoS Pathog· July 2024

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Validation of Trypanosoma cruzi inactivation techniques for laboratory use.
Lorna M MacLean, Mark Ariyanayagam, Lalitha Sastry, Christy Paterson, Manu De Rycker, Alan H Fairlamb

PLoS One· April 2024

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Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Susan Wyllie, Michael Thomas, Stephen Patterson, Sabrinia Crouch, Manu De Rycker, Alan H Fairlamb

Nature· July 2023

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The critical role of mode of action studies in kinetoplastid drug discovery.
Alan H Fairlamb, Susan Wyllie

Front Drug Discov (Lausanne)· May 2023

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Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases.
Felix Calderón, Lluis Ballell, David Barros, Graeme Bilbe, Nicholas Cammack, Alan H Fairlamb

Nat Rev Drug Discov· November 2021

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Surmounting structural barriers to tackle endemic infectious diseases.
Felix Calderón, Alan H Fairlamb, Mike Strange, Pauline Williams, Carl F Nathan

J Exp Med· September 2021

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Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.
Juliana da Silva Pacheco, Débora de Souza Costa, Edézio Ferreira Cunha-Júnior, Valter Viana Andrade-Neto, Alan H Fairlamb

ACS Med Chem Lett· September 2021

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Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Luciana S Paradela, Richard J Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Alan H Fairlamb

Cell Chem Biol· May 2021

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Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties.
Cyril Fersing, Clotilde Boudot, Romain Paoli-Lombardo, Nicolas Primas, Emilie Pinault, Alan H Fairlamb

Eur J Med Chem· November 2020

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8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
Cyril Fersing, Clotilde Boudot, Caroline Castera-Ducros, Emilie Pinault, Sébastien Hutter, Alan H Fairlamb

Eur J Med Chem· September 2020

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Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase.
Leah S Torrie, David A Robinson, Michael G Thomas, Judith V Hobrath, Sharon M Shepherd, Alan H Fairlamb

ACS Infect Dis· May 2020

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New 8-Nitroquinolinone Derivative Displaying Submicromolar Activities against Both and .
Julien Pedron, Clotilde Boudot, Jean-Yves Brossas, Emilie Pinault, Sandra Bourgeade-Delmas, Alan H Fairlamb

ACS Med Chem Lett· April 2020

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The Q Site of Cytochrome is a Promiscuous Drug Target in and .
Richard J Wall, Sandra Carvalho, Rachel Milne, Juan A Bueren-Calabuig, Sonia Moniz, Alan H Fairlamb

ACS Infect Dis· March 2020

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Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
Neil R Norcross, Caroline Wilson, Beatriz Baragaña, Irene Hallyburton, Maria Osuna-Cabello, Alan H Fairlamb

ChemMedChem· July 2019

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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-Wa Chung, Alan H Fairlamb

Proc Natl Acad Sci U S A· May 2019

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Beatriz Baragaña, Barbara Forte, Ryan Choi, Stephen Nakazawa Hewitt, Juan A Bueren-Calabuig, Alan H Fairlamb

Proc Natl Acad Sci U S A· April 2019

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Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.
Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J Wall, Leah S Torrie, Alan H Fairlamb

ACS Infect Dis· January 2019

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Nongenotoxic 3-Nitroimidazo[1,2-]pyridines Are NTR1 Substrates That Display Potent Antileishmanial Activity.
Cyril Fersing, Louise Basmaciyan, Clotilde Boudot, Julien Pedron, Sébastien Hutter, Alan H Fairlamb

ACS Med Chem Lett· January 2019

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Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.
Mark C Field, David Horn, Alan H Fairlamb, Michael A J Ferguson, David W Gray

Nat Rev Microbiol· November 2018

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Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions.
Julien Pedron, Clotilde Boudot, Sandra Bourgeade-Delmas, Alix Sournia-Saquet, Lucie Paloque, Alan H Fairlamb

ChemMedChem· October 2018

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Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.
Lauren A Webster, Michael Thomas, Michael Urbaniak, Susan Wyllie, Han Ong, Alan H Fairlamb

ACS Infect Dis· October 2018

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8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.
Cyril Fersing, Clotilde Boudot, Julien Pedron, Sébastien Hutter, Nicolas Primas, Alan Fairlamb

Eur J Med Chem· September 2018

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A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.
Adam J Roberts, Joanne Dunne, Paul Scullion, Suzanne Norval, Alan H Fairlamb

Biochem J· August 2018

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Susan Wyllie, Michael Thomas, Stephen Patterson, Sabrinia Crouch, Manu De Rycker, Alan H Fairlamb

Nature· August 2018

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