Publications by authors named "Alan Holmes"

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High-resolution ocean color imagery from the SeaHawk-HawkEye CubeSat mission.
Philip J Bresnahan, Sara Rivero-Calle, John Morrison, Gene Feldman, Alan Holmes

Sci Data· November 2024

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Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension.
Angela Y Y Tam, Amy L Horwell, Sarah L Trinder, Korsa Khan, Shiwen Xu, Alan M Holmes

Int J Biochem Cell Biol· May 2021

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Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing.
Deborah L W Chong, Sarah Trinder, Myriam Labelle, Manuel Rodriguez-Justo, Sian Hughes, Alan M Holmes

J Tissue Eng Regen Med· April 2020

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.
Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Yuki Ishii, Stacey Price, Alan Holmes

Elife· January 2018

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Does age matter? The impact of rodent age on study outcomes.
Samuel J Jackson, Nick Andrews, Doug Ball, Ilaria Bellantuono, James Gray, Alan Holmes

Lab Anim· April 2017

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Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Robert B Good, Adrian J Gilbane, Sarah L Trinder, Christopher P Denton, Gerry Coghlan, Alan M Holmes

Am J Pathol· July 2015

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Impaired bone morphogenetic protein receptor II signaling in a transforming growth factor-β-dependent mouse model of pulmonary hypertension and in systemic sclerosis.
Adrian J Gilbane, Emma Derrett-Smith, Sarah L Trinder, Robert B Good, Andrew Pearce, Alan M Holmes

Am J Respir Crit Care Med· March 2015

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Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis.
Markella Ponticos, Ioannis Papaioannou, Shiwen Xu, Alan M Holmes, Korsa Khan

Arthritis Rheumatol· January 2015

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Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells.
Adrian J Gilbane, Christopher P Denton, Alan M Holmes

Arthritis Res Ther· November 2014

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Evidence for the involvement of type I interferon in pulmonary arterial hypertension.
Peter M George, Eduardo Oliver, Peter Dorfmuller, Olivier D Dubois, Daniel M Reed, Alan M Holmes

Circ Res· February 2014

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Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.
Emma C Derrett-Smith, Audrey Dooley, Adrian J Gilbane, Sarah L Trinder, Korsa Khan, Alan M Holmes

Arthritis Rheum· November 2013

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Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.
Xiaoyan Tang, Ruoqi Peng, Jonathan E Phillips, Jeremy Deguzman, Yonglin Ren, Alan M Holmes

Am J Pathol· August 2013

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Encouraging smoking cessation during pregnancy in West Virginia: using Fax-to-Quit as a cessation strategy.
Cindy Tworek, Kimberly A Horn, Robert H Anderson, Ilana Chertok, Robin L Danek, Alan Holmes

W V Med J· June 2013

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Targeting TGFβ superfamily ligand accessory proteins as novel therapeutics for chronic lung disorders.
David C Budd, Alan M Holmes

Pharmacol Ther· September 2012

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BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines.
Rachel J Davies, Alan M Holmes, John Deighton, Lu Long, Xudong Yang

Am J Physiol Lung Cell Mol Physiol· March 2012

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A novel murine model of severe pulmonary arterial hypertension.
Loredana Ciuclan, Olivier Bonneau, Martin Hussey, Nicholas Duggan, Alan M Holmes

Am J Respir Crit Care Med· November 2011

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Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.
Victoria J Burton, Alan M Holmes, Loredana I Ciuclan, Alexander Robinson, Jan S Roger

Blood· October 2011

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Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin.
Alan M Holmes, Markella Ponticos, Xu Shi-Wen, Christopher P Denton, David J Abraham

J Cell Commun Signal· August 2011

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Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.
Victoria J Burton, Loredana I Ciuclan, Alan M Holmes, David M Rodman, Christoph Walker

Blood· January 2011

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Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.
Elaine Soon, Alan M Holmes, Carmen M Treacy, Natalie J Doughty, Laura Southgate

Circulation· August 2010

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Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
Markella Ponticos, Alan M Holmes, Xu Shi-wen, Patricia Leoni, Korsa Khan

Arthritis Rheum· July 2009

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Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.
Matthew Thomas, Cerys Docx, Alan M Holmes, Sarah Beach, Nicholas Duggan

Am J Pathol· February 2009

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Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function.
Andrew Leask, Xu Shi-Wen, Korsa Khan, Yunliang Chen, Alan Holmes

J Cell Sci· October 2008

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A polymorphism in the CTGF promoter region associated with systemic sclerosis.
Carmen Fonseca, Gisela E Lindahl, Markella Ponticos, Piersante Sestini, Elisabetta A Renzoni, Alan M Holmes

N Engl J Med· September 2007

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Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Xu Shi-Wen, Fernando Rodríguez-Pascual, Santiago Lamas, Alan Holmes, Sarah Howat

Mol Cell Biol· July 2006

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