Publications by authors named "Alex B Burgin"

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Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.
Lisa Brenan, Aleksandr Andreev, Ofir Cohen, Sasha Pantel, Atanas Kamburov, Alex B Burgin

Cell Rep· October 2016

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A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Matthew C Clifton, David M Dranow, Alison Leed, Ben Fulroth, James W Fairman, Alex B Burgin

PLoS One· April 2016

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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
Luc de Waal, Timothy A Lewis, Matthew G Rees, Aviad Tsherniak, Xiaoyun Wu, Alex B Burgin

Nat Chem Biol· February 2016

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Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor.
Thale C Jarvis, Douglas R Davies, Akihiko Hisaminato, Daniel I Resnicow, Shashi Gupta, Alex B Burgin

Structure· July 2015

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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins.
Savannah E Sanchez, Daniel A Cuevas, Jason E Rostron, Tiffany Y Liang, Cullen G Pivaroff, Alex B Burgin

J Vis Exp· June 2015

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Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease.
Mark E Gurney, Emily C D'Amato, Alex B Burgin

Neurotherapeutics· January 2015

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Discovery of triazines as selective PDE4B versus PDE4D inhibitors.
Timothy J Hagen, Xuesheng Mo, Alex B Burgin, David Fox, Zheng Zhang

Bioorg Med Chem Lett· August 2014

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Structural basis for the design of selective phosphodiesterase 4B inhibitors.
David Fox, Alex B Burgin, Mark E Gurney

Cell Signal· March 2014

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Structure and function of a cyanophage-encoded peptide deformylase.
Jeremy A Frank, Don Lorimer, Merry Youle, Pam Witte, Tim Craig, Alex B Burgin

ISME J· June 2013

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Artificial neural networks trained to detect viral and phage structural proteins.
Victor Seguritan, Nelson Alves, Michael Arnoult, Amy Raymond, Don Lorimer, Alex B Burgin

PLoS Comput Biol· December 2012

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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Douglas R Davies, Amy D Gelinas, Chi Zhang, John C Rohloff, Jeffrey D Carter, Alex B Burgin

Proc Natl Acad Sci U S A· December 2012

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Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Alex B Burgin

Cell· February 2012

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Small molecule allosteric modulators of phosphodiesterase 4.
Mark E Gurney, Alex B Burgin, Olafur T Magnusson, Lance J Stewart

Handb Exp Pharmacol· September 2011

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Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
Steven L Pitts, Grace F Liou, Lesley A Mitchenall, Alex B Burgin, Anthony Maxwell

Nucleic Acids Res· June 2011

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A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Bryan H Schmidt, Alex B Burgin, Joseph E Deweese, Neil Osheroff, James M Berger

Nature· June 2010

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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Alex B Burgin, Olafur T Magnusson, Jasbir Singh, Pam Witte, Bart L Staker

Nat Biotechnol· January 2010

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Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.
Joseph E Deweese, F Peter Guengerich, Alex B Burgin, Neil Osheroff

Biochemistry· September 2009

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Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Douglas R Davies, Bjorn Mamat, Olafur T Magnusson, Jeff Christensen, Magnus H Haraldsson, Alex B Burgin

J Med Chem· August 2009

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Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.
Joseph E Deweese, Amber M Burch, Alex B Burgin, Neil Osheroff

Biochemistry· March 2009

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Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.
Joseph E Deweese, Alex B Burgin, Neil Osheroff

Nucleic Acids Res· September 2008

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Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha.
Joseph E Deweese, Alex B Burgin, Neil Osheroff

Biochemistry· April 2008

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Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase).
Amy C Raymond, Alex B Burgin

Methods Enzymol· August 2006

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.
Christophe Marchand, Smitha Antony, Kurt W Kohn, Mark Cushman, Alexandra Ioanoviciu, Alex B Burgin

Mol Cancer Ther· February 2006

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Uncoupling the chemical steps of telomere resolution by ResT.
Kerri Kobryn, Alex B Burgin, George Chaconas

J Biol Chem· July 2005

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Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1).
Amy C Raymond, Bart L Staker, Alex B Burgin

J Biol Chem· June 2005

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