Publications by authors named "Alexander Bridges"

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Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics.
Carrie S Tambo, Sarvind Tripathi, B Gayani K Perera, Dustin J Maly, Alexander J Bridges

ACS Chem Biol· February 2023

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Race-based disparities in access to surgical palliation for hypoplastic left heart syndrome.
Catherine G Williamson, Zachary Tran, Sarah Rudasill, Joseph Hadaya, Arjun Verma, Alexander W Bridges

Surgery· August 2022

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Disruptin, a cell-penetrating peptide degrader of EGFR: Cell-Penetrating Peptide in Cancer Therapy.
Ranjit K Mehta, Sushmita Shukla, Susmita G Ramanand, Vishal Somnay, Alexander J Bridges

Transl Oncol· August 2021

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Drug-development, dose-selection, rational combinations from bench-to-bedside: are there any lessons worth revisiting?
Alexander J Bridges, Ranjit K Mehta, Sushmita Shukla, Matthew J Schipper, Theodore S Lawrence

Oncotarget· May 2021

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Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors.
Paramita Ray, Yee Sun Tan, Vishal Somnay, Ranjit Mehta, Merna Sitto, Alexander Bridges

Oncotarget· October 2016

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Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.
Jeff B Smaill, Andrea J Gonzales, Julie A Spicer, Helen Lee, Jessica E Reed, Alexander Bridges

J Med Chem· September 2016

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Successes and challenges of insulin therapy for type 2 diabetes in a managed-care setting.
Gregory A Nichols, Shravanthi R Gandra, Chiun-Fang Chiou, Mary S Anthony, Maria Alexander-Bridges

Curr Med Res Opin· January 2010

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2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).
Joseph S Warmus, Cathlin Flamme, Lu Yan Zhang, Stephen Barrett, Alexander Bridges

Bioorg Med Chem Lett· December 2008

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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Stephen D Barrett, Alexander J Bridges, David T Dudley, Alan R Saltiel, James H Fergus

Bioorg Med Chem Lett· December 2008

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Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.
Jeff B Smaill, Edward N Baker, R John Booth, Alexander J Bridges, James M Dickson

Eur J Med Chem· June 2008

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Commentary on "increasing minority participation in clinical research": a white paper from the endocrine society.
Maria Alexander-Bridges, Loretta L Doan,

J Clin Endocrinol Metab· December 2007

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Amyloid-beta(1-42) rapidly forms protofibrils and oligomers by distinct pathways in low concentrations of sodium dodecylsulfate.
Vijayaraghavan Rangachari, Brenda D Moore, Dana Kim Reed, Leilani K Sonoda, Alexander W Bridges

Biochemistry· October 2007

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Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.
Sylvester R Klutchko, Hairong Zhou, R Thomas Winters, Tuan P Tran, Alexander J Bridges

J Med Chem· February 2006

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Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
Kan He, Rasmy E Talaat, William F Pool, Michael D Reily, Jessica E Reed, Alexander J Bridges

Drug Metab Dispos· June 2004

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Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.
C M Cahill, G Tzivion, N Nasrin, S Ogg, J Dore, M Alexander-Bridges

J Biol Chem· April 2001

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DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.
N Nasrin, S Ogg, C M Cahill, W Biggs, S Nui, M C Alexander-Bridges

Proc Natl Acad Sci U S A· September 2000

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IRE-ABP (insulin response element-A binding protein), an SRY-like protein, inhibits C/EBPalpha (CCAAT/enhancer-binding protein alpha)-stimulated expression of the sex-specific cytochrome P450 2C12 gene.
C Buggs, N Nasrin, A Mode, P Tollet, H F Zhao, M Alexander-Bridges

Mol Endocrinol· September 1998

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Multiple insulin-responsive elements regulate transcription of the GAPDH gene.
M Alexander-Bridges, I Dugast, L Ercolani, X F Kong, L Giere

Adv Enzyme Regul· September 1992

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Growth factor-activated kinases phosphorylate IRE-ABP.
M Alexander-Bridges, N K Mukhopadhyay, U Jhala, M Denaro, X F Kong

Biochem Soc Trans· August 1992

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Identification of a core motif that is recognized by three members of the HMG class of transcriptional regulators: IRE-ABP, SRY, and TCF-1 alpha.
M Alexander-Bridges, L Ercolani, X F Kong, N Nasrin

J Cell Biochem· February 1992

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Models of insulin action on metabolic and growth response genes.
M Alexander-Bridges, C Buggs, L Giere, M Denaro, B Kahn

Mol Cell Biochem· February 1992

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DNA-binding properties of the product of the testis-determining gene and a related protein.
N Nasrin, C Buggs, X F Kong, J Carnazza, M Goebl, M Alexander-Bridges

Nature· November 1991

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