Publications by authors named "Alexander Mayweg"

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Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus.
Buyu Kou, Zhisen Zhang, Xingchun Han, Zheng Zhou, Zhiheng Xu, Alexander Mayweg

J Med Chem· October 2023

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Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.
Weixing Zhang, Lei Guo, Haixia Liu, Guolong Wu, Houguang Shi, Alexander V Mayweg

J Med Chem· March 2023

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Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
Yongfu Liu, Jun Wu, Mingwei Zhou, Wenming Chen, Dongbo Li, Alexander V Mayweg

J Med Chem· July 2020

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Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action.
Xingchun Han, Chengang Zhou, Min Jiang, Yongguang Wang, Jianhua Wang, Alexander V Mayweg

J Med Chem· December 2018

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Discovery of potent and selective CDK8 inhibitors through FBDD approach.
Xingchun Han, Min Jiang, Chengang Zhou, Zheng Zhou, Zhiheng Xu, Alexander V Mayweg

Bioorg Med Chem Lett· September 2017

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Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.
Zongxing Qiu, Xianfeng Lin, Weixing Zhang, Mingwei Zhou, Lei Guo, Alexander V Mayweg

J Med Chem· April 2017

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Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.
Zongxing Qiu, Xianfeng Lin, Mingwei Zhou, Yongfu Liu, Wei Zhu, Alexander V Mayweg

J Med Chem· August 2016

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).
Rainer E Martin, Johannes Lehmann, Thibaut Alzieu, Mario Lenz, Marjorie A Carnero Corrales, Alexander V Mayweg

Org Biomol Chem· July 2016

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Werner Neidhart, Jean Ackermann, Kurt Amrein, Aurelia Conte, Daniel Hunziker, Alexander V Mayweg

Chimia (Aarau)· December 2015

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Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
Rainer E Martin, Johannes D Aebi, Benoit Hornsperger, Hans-Jakob Krebs, Bernd Kuhn, Alexander V Mayweg

J Med Chem· October 2015

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Werner Neidhart, Jean Ackermann, Kurt Amrein, Aurelia Conte, Daniel Hunziker, Alexander V Mayweg

Chimia (Aarau)· August 2015

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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.
Zhisen Zhang, Zhaohu Lin, Zheng Zhou, Hong C Shen, S Frank Yan, Alexander V Mayweg

ACS Med Chem Lett· September 2014

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BACE1 inhibitors: a head group scan on a series of amides.
Thomas J Woltering, Wolfgang Wostl, Hans Hilpert, Mark Rogers-Evans, Emmanuel Pinard, Alexander Mayweg

Bioorg Med Chem Lett· July 2013

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β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.
Hans Hilpert, Wolfgang Guba, Thomas J Woltering, Wolfgang Wostl, Emmanuel Pinard, Alexander V Mayweg

J Med Chem· May 2013

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Transannular Claisen rearrangement reactions for the synthesis of vinylcyclobutanes: formal synthesis of (±)-grandisol.
Donald Craig, Kiyohiko Funai, Sophie J Gore, Albert Kang, Alexander V W Mayweg

Org Biomol Chem· December 2011

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ROCK: the Roche medicinal chemistry knowledge application - design, use and impact.
Alexander Mayweg, Urs Hofer, Patrick Schnider, Fausto Agnetti, Guido Galley

Drug Discov Today· August 2011

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Transannular, decarboxylative Claisen rearrangement reactions for the synthesis of sulfur-substituted vinylcyclopropanes.
Donald Craig, Sophie J Gore, Mark I Lansdell, Simon E Lewis, Alexander V W Mayweg

Chem Commun (Camb)· July 2010

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Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.
Leo Alig, Jochem Alsenz, Mirjana Andjelkovic, Stefanie Bendels, Agnès Bénardeau, Alexander V Mayweg

J Med Chem· April 2008

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Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues.
Paul A Wender, Michael K Hilinski, Alexander V W Mayweg

Org Lett· January 2005

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A concise, selective synthesis of the polyketide spacer domain of a potent bryostatin analogue.
Paul A Wender, Alexander V W Mayweg, Christopher L VanDeusen

Org Lett· February 2003

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Biomimetic cycloaddition approach to tropolone natural products via a tropolone ortho-quinone methide.
Robert M Adlington, Jack E Baldwin, Alexander V W Mayweg, Gareth J Pritchard

Org Lett· August 2002

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