Publications by authors named "Alexander Pavlovsky"

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Corrigendum: Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα.
Yunmei Wang, Huiyun Gao, Can Shi, Paul W Erhardt, Alexander Pavlovsky

Nat Commun· July 2017

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Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα.
Yunmei Wang, Huiyun Gao, Can Shi, Paul W Erhardt, Alexander Pavlovsky

Nat Commun· May 2017

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A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Alexander G Pavlovsky, Bharani Thangavelu, Pravin Bhansali, Ronald E Viola

Acta Crystallogr D Biol Crystallogr· December 2014

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Structure of homoserine O-acetyltransferase from Staphylococcus aureus: the first Gram-positive ortholog structure.
Bharani Thangavelu, Alexander G Pavlovsky, Ronald Viola

Acta Crystallogr F Struct Biol Commun· October 2014

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Aspartoacylase catalytic deficiency as the cause of Canavan disease: a structural perspective.
Yasanandana S Wijayasinghe, Alexander G Pavlovsky, Ronald E Viola

Biochemistry· August 2014

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Structure of an unusual S-adenosylmethionine synthetase from Campylobacter jejuni.
Stephen P Zano, Alexander G Pavlovsky, Ronald E Viola

Acta Crystallogr D Biol Crystallogr· February 2014

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The catalytic machinery of a key enzyme in amino Acid biosynthesis.
Ronald E Viola, Christopher R Faehnle, Julio Blanco, Roger A Moore, Xuying Liu, Alexander G Pavlovsky

J Amino Acids· August 2012

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Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase.
Amarjit Luniwal, Lin Wang, Alexander Pavlovsky, Paul W Erhardt, Ronald E Viola

Bioorg Med Chem· May 2012

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Structural characterization of inhibitors with selectivity against members of a homologous enzyme family.
Alexander G Pavlovsky, Xuying Liu, Christopher R Faehnle, Nina Potente, Ronald E Viola

Chem Biol Drug Des· January 2012

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Identification of selective enzyme inhibitors by fragment library screening.
Geng Gao, Xuying Liu, Alexander Pavlovsky, Ronald E Viola

J Biomol Screen· October 2010

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Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog.
Buenafe T Arachea, Xuying Liu, Alexander G Pavlovsky, Ronald E Viola

Acta Crystallogr D Biol Crystallogr· February 2010

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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Mark E Schnute, Patrick M O'Brien, Joe Nahra, Mark Morris, W Howard Roark, Alexander G Pavlovsky

Bioorg Med Chem Lett· January 2010

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A randomised Phase III trial of glufosfamide compared with best supportive care in metastatic pancreatic adenocarcinoma previously treated with gemcitabine.
Tudor E Ciuleanu, Alexander V Pavlovsky, Gyorgy Bodoky, Avgust M Garin, Virginia K Langmuir

Eur J Cancer· June 2009

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2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).
Joseph S Warmus, Cathlin Flamme, Lu Yan Zhang, Stephen Barrett, Alexander Bridges, Alexander Pavlovsky

Bioorg Med Chem Lett· December 2008

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Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Ronald W Sarver, Elizabeth Bills, Gary Bolton, Larry D Bratton, Nicole L Caspers, Alexander Pavlovsky

J Med Chem· July 2008

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The structural basis for allosteric inhibition of a threonine-sensitive aspartokinase.
Xuying Liu, Alexander G Pavlovsky, Ronald E Viola

J Biol Chem· June 2008

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Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue.
Johanne Le Coq, Alexander Pavlovsky, Radhika Malik, Ruslan Sanishvili, Chengfu Xu

Biochemistry· March 2008

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Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
Jeffrey A Pfefferkorn, Chulho Choi, Scott D Larsen, Bruce Auerbach, Richard Hutchings, Alexander Pavlovsky

J Med Chem· January 2008

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4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
Julie A Spicer, Gordon W Rewcastle, Michael D Kaufman, Shannon L Black, Mark S Plummer, Alexander G Pavlovsky

J Med Chem· October 2007

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Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
Adam R Johnson, Alexander G Pavlovsky, Daniel F Ortwine, Faith Prior, Chiu-Fai Man

J Biol Chem· September 2007

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Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Jeffrey A Pfefferkorn, Chulho Choi, Yuntao Song, Bharat K Trivedi, Scott D Larsen, Alexander Pavlovsky

Bioorg Med Chem Lett· August 2007

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Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Jeffrey A Pfefferkorn, Yuntao Song, Kuai-Lin Sun, Steven R Miller, Bharat K Trivedi, Alexander Pavlovsky

Bioorg Med Chem Lett· August 2007

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The initial step in the archaeal aspartate biosynthetic pathway catalyzed by a monofunctional aspartokinase.
Christopher R Faehnle, Xuying Liu, Alexander Pavlovsky, Ronald E Viola

Acta Crystallogr Sect F Struct Biol Cryst Commun· October 2006

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Jeffrey F Ohren, Huifen Chen, Alexander Pavlovsky, Christopher Whitehead, Erli Zhang

Nat Struct Mol Biol· December 2004

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