Publications by authors named "Alexandra Gould"

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Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.
Subrata Shaw, Wei Jiang, Jason Rush, Nancy Dumont, John Kim, Alexandra E Gould

iScience· March 2025

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A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
Stanley C Xie, Chia-Wei Tai, Craig J Morton, Liting Ma, Shih-Chung Huang, Alexandra E Gould

PLoS Pathog· December 2024

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Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform.
Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Alexandra E Gould

bioRxiv· May 2024

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Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Ioanna Deni, Barbara H Stokes, Kurt E Ward, Kate J Fairhurst, Charisse Flerida A Pasaje, Alexandra E Gould

Cell Chem Biol· May 2023

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Target-driven machine learning-enabled virtual screening (TAME-VS) platform for early-stage hit identification.
Yuemin Bian, Jason J Kwon, Cong Liu, Enrico Margiotta, Mrinal Shekhar, Alexandra E Gould

Front Mol Biosci· March 2023

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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Wei-Sheng Huang, Feng Li, Yongjin Gong, Yun Zhang, Willmen Youngsaye, Alexandra E Gould

Bioorg Med Chem Lett· January 2023

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Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
Shreeya Garg, Oriana Kreutzfeld, Sevil Chelebieva, Patrick K Tumwebaze, Oswald Byaruhanga, Alexandra E Gould

Antimicrob Agents Chemother· October 2022

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Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Stanley C Xie, Riley D Metcalfe, Elyse Dunn, Craig J Morton, Shih-Chung Huang, Alexandra E Gould

Science· June 2022

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Concerns regarding McClintock et al. Oral dexamethasone sodium phosphate solution significantly reduces pruritus and clinical lesions in feline hypersensitivity dermatitis: an open-label study.
Kimberly Coyner, Alexandra Gould, Ann Trimmer

Vet Dermatol· April 2022

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Efficacy of ulipristal acetate in women with fibroid induced menorrhagia: A systematic review and meta-analysis.
Georgios Kounidas, Stavroula Lila Kastora, Emma Barnott, Lydia Black, Tamara Robinson-Burke, Alexandra Gould

J Gynecol Obstet Hum Reprod· November 2021

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Canine pedal papilloma identification and management: a retrospective series of 44 cases.
Alexandra P Gould, Kimberly S Coyner, Ann M Trimmer, Kathy Tater, Mark Rishniw

Vet Dermatol· October 2021

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Design of proteasome inhibitors with oral efficacy in vivo against and selectivity over the human proteasome.
Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Alexandra E Gould

Proc Natl Acad Sci U S A· September 2021

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Mobocertinib (TAK-788): A Targeted Inhibitor of Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer.
Francois Gonzalvez, Sylvie Vincent, Theresa E Baker, Alexandra E Gould, Shuai Li

Cancer Discov· July 2021

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Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
Stepan Vyskocil, David Cardin, Jeffrey Ciavarri, Joe Conlon, Courtney Cullis, Alexandra Gould

J Med Chem· May 2021

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Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors.
Shih-Chung Huang, Sharmila Adhikari, James E Brownell, Emily F Calderwood, Jouhara Chouitar, Alexandra E Gould

Bioorg Med Chem· October 2020

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Recovery of meticillin-resistant Staphylococcus species from pet-grooming salons.
Alexandra P Gould, Kimberly S Coyner, Ann M Trimmer, J Scott Weese, Christine M Budke

Vet Dermatol· August 2020

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The proteasome as a target for protozoan parasites.
Stanley C Xie, Lawrence R Dick, Alexandra Gould, Stephen Brand, Leann Tilley

Expert Opin Ther Targets· November 2019

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Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.
Stanley C Xie, David L Gillett, Natalie J Spillman, Christopher Tsu, Madeline R Luth, Alexandra E Gould

J Med Chem· November 2018

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Cardiac arrest in an American Cocker Spaniel during a deep ear flush procedure.
Alexandra Gould, Fernando L Garcia-Pereira, W Dunbar Gram

J Am Vet Med Assoc· May 2017

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Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG.
Shih-Chung Huang, Sharmila Adhikari, Roushan Afroze, Katherine Brewer, Emily F Calderwood, Alexandra E Gould

Bioorg Med Chem Lett· February 2016

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Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.
Christopher Blackburn, Cynthia Barrett, Mable Brunson, Janice Chin, Dylan England, Alexandra Gould

Bioorg Med Chem Lett· December 2014

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Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.
James M Gavin, Kara Hoar, Qing Xu, Jingya Ma, Yafang Lin, Alexandra E Gould

J Biol Chem· August 2014

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Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform.
Christopher Blackburn, Cynthia Barrett, Janice Chin, Kris Garcia, Kenneth Gigstad, Alexandra Gould

J Med Chem· September 2013

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Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.
James M Gavin, Jesse J Chen, Hua Liao, Neil Rollins, Xiaofeng Yang, Alexandra E Gould

J Biol Chem· May 2012

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Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors.
Alexandra E Gould, Ruth Adams, Sharmila Adhikari, Kathleen Aertgeerts, Roushan Afroze

J Med Chem· March 2011

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