Publications by authors named "Lawrence R Dick"

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A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
Stanley C Xie, Chia-Wei Tai, Craig J Morton, Liting Ma, Shih-Chung Huang, Lawrence R Dick

PLoS Pathog· December 2024

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Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Stanley C Xie, Riley D Metcalfe, Elyse Dunn, Craig J Morton, Shih-Chung Huang, Lawrence R Dick

Science· June 2022

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Design of proteasome inhibitors with oral efficacy in vivo against and selectivity over the human proteasome.
Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Lawrence R Dick

Proc Natl Acad Sci U S A· September 2021

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The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Lawrence R Dick

Nat Microbiol· November 2019

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The proteasome as a target for protozoan parasites.
Stanley C Xie, Lawrence R Dick, Alexandra Gould, Stephen Brand, Leann Tilley

Expert Opin Ther Targets· November 2019

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Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.
Stanley C Xie, David L Gillett, Natalie J Spillman, Christopher Tsu, Madeline R Luth, Lawrence R Dick

J Med Chem· November 2018

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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome.
Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann, Lawrence R Dick

Nat Commun· September 2018

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Lawrence R Dick

Nat Med· February 2018

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.
Xingyue He, Jessica Riceberg, Teresa Soucy, Erik Koenig, James Minissale, Lawrence R Dick

Nat Chem Biol· November 2017

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Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.
Tatos Akopian, Olga Kandror, Christopher Tsu, Jack H Lai, Wengen Wu, Lawrence R Dick

J Biol Chem· April 2015

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Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.
James M Gavin, Kara Hoar, Qing Xu, Jingya Ma, Yafang Lin, Lawrence R Dick

J Biol Chem· August 2014

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Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometry.
Xiaofeng Yang, James E Brownell, Qing Xu, Fengying Zhu, Jingya Ma, Lawrence R Dick

Cell Biochem Biophys· September 2013

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Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen.
Zhong-Hua Yan, Anne Burkhardt, Huay-Keng Loke, Jesse Chen, Qing Xu, Lawrence R Dick

Anal Biochem· August 2013

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Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.
James M Gavin, Jesse J Chen, Hua Liao, Neil Rollins, Xiaofeng Yang, Lawrence R Dick

J Biol Chem· May 2012

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Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.
Michael A Milhollen, Michael P Thomas, Usha Narayanan, Tary Traore, Jessica Riceberg, Lawrence R Dick

Cancer Cell· March 2012

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Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes.
Roland Hjerpe, Yann Thomas, Jesse Chen, Aleksandra Zemla, Siobhan Curran, Lawrence R Dick

Biochem J· February 2012

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Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues.
Jesse J Chen, Christopher A Tsu, James M Gavin, Michael A Milhollen, Frank J Bruzzese, Lawrence R Dick

J Biol Chem· November 2011

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Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.
Lynn Bedford, James Lowe, Lawrence R Dick, R John Mayer, James E Brownell

Nat Rev Drug Discov· January 2011

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Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Christopher Blackburn, Cynthia Barrett, Jonathan L Blank, Frank J Bruzzese, Nancy Bump, Lawrence R Dick

Bioorg Med Chem Lett· November 2010

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma.
Michael A Milhollen, Tary Traore, Jennifer Adams-Duffy, Michael P Thomas, Allison J Berger, Lawrence R Dick

Blood· September 2010

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Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Christopher Blackburn, Kenneth M Gigstad, Paul Hales, Khristofer Garcia, Matthew Jones, Lawrence R Dick

Biochem J· September 2010

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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.
Teresa A Soucy, Lawrence R Dick, Peter G Smith, Michael A Milhollen, James E Brownell

Genes Cancer· July 2010

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Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy.
Lawrence R Dick, Paul E Fleming

Drug Discov Today· March 2010

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Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
James E Brownell, Michael D Sintchak, James M Gavin, Hua Liao, Frank J Bruzzese, Lawrence R Dick

Mol Cell· January 2010

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Development of a charcoal paper adenosine triphosphate:pyrophosphate exchange assay: kinetic characterization of NEDD8 activating enzyme.
Frank J Bruzzese, Christopher A Tsu, Jingya Ma, Huay-Keng Loke, Dongyun Wu, Lawrence R Dick

Anal Biochem· November 2009

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