Publications by authors named "Alice Ke"

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Sensitivity of Tepotinib to Inhibitors or Inducers of CYP3A4 and P-Gp: Drug Interaction Studies and Physiologically-Based Pharmacokinetic Analysis.
Rainer Strotmann, Christian Lüpfert, Axel Krebs-Brown, Alice Ke, Matthias Boedding

Clin Transl Sci· July 2025

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Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children.
Estefania Traver, Laura Rodríguez-Pascau, Uwe Meya, Guillem Pina, Silvia Pascual, Alice Ke

CPT Pharmacometrics Syst Pharmacol· June 2024

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Physiologically-based pharmacokinetic modeling of the drug-drug interaction between ivacaftor and lefamulin in cystic fibrosis patients.
Magali Amiel, Alice Ke, Steven P Gelone, Hannah M Jones, Wolfgang Wicha

CPT Pharmacometrics Syst Pharmacol· April 2024

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Managing Drug-Drug Interactions in Older Adults.
Zhu Zhou, Patricia W Slattum, Alice Ke, Lei Zhang

J Clin Pharmacol· October 2023

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Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.
Peter J Kilford, Kuan-Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke

CPT Pharmacometrics Syst Pharmacol· July 2022

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Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations.
Laura Oggianu, Giorgio Di Dato, Giorgina Mangano, Maria Teresa Rosignoli, Savannah McFeely, Alice Ban Ke

Clin Transl Sci· June 2022

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PBPK modeling to predict drug-drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction.
Jayaprakasam Bolleddula, Alice Ke, Hua Yang, Chandra Prakash

CPT Pharmacometrics Syst Pharmacol· June 2021

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Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?
Trevor N Johnson, Alice B Ke

J Clin Pharmacol· June 2021

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Physiologically based pharmacokinetic modeling and simulation to predict drug-drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia.
Chandra Prakash, Bin Fan, Alice Ke, Kha Le, Hua Yang

Cancer Chemother Pharmacol· November 2020

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A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.
Mailys De Sousa Mendes, Oliver Hatley, Katherine Linda Gill, Karen Rowland Yeo, Alice Ban Ke

Eur J Pharm Sci· July 2020

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Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction.
Laura Oggianu, Alice B Ke, Manoranjenni Chetty, Rossella Picollo, Vanessa Petrucci

CPT Pharmacometrics Syst Pharmacol· February 2020

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Evaluation of Maternal Drug Exposure Following the Administration of Antenatal Corticosteroids During Late Pregnancy Using Physiologically-Based Pharmacokinetic Modeling.
Alice Ban Ke, Mark A Milad

Clin Pharmacol Ther· July 2019

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Model-Informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor.
Neeraj Gupta, Michael J Hanley, Paul M Diderichsen, Huyuan Yang, Alice Ke

Clin Pharmacol Ther· February 2019

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In vitro to in vivo extrapolation for high throughput prioritization and decision making.
Shannon M Bell, Xiaoqing Chang, John F Wambaugh, David G Allen, Mike Bartels, Alice Ke

Toxicol In Vitro· March 2018

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Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis.
Neeraj Gupta, Michael J Hanley, Karthik Venkatakrishnan, Alberto Bessudo, Drew W Rasco, Alice Ke

J Clin Pharmacol· February 2018

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Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations.
Alice Ban Ke, Rick Greupink, Khaled Abduljalil

CPT Pharmacometrics Syst Pharmacol· February 2018

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Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.
Fang Xie, Alice B Ke, Gary D Bowers, Maciej J Zamek-Gliszczynski

J Pharmacol Exp Ther· August 2015

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Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.
David S Small, Alice Ban Ke, Stephen D Hall, Nathan Mantlo, Matthew Rotelli

J Clin Pharmacol· July 2015

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Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.
J William Higgins, Alice B Ke, Maciej J Zamek-Gliszczynski

Drug Metab Dispos· November 2014

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Pharmacometrics in pregnancy: An unmet need.
Alice Ban Ke, Amin Rostami-Hodjegan, Ping Zhao, Jashvant D Unadkat

Annu Rev Pharmacol Toxicol· September 2014

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Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk.
Maciej J Zamek-Gliszczynski, Michael A Mohutsky, Jessica L F Rehmel, Alice B Ke

Drug Metab Dispos· June 2014

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Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.
Alice Ban Ke, Srikanth C Nallani, Ping Zhao, Amin Rostami-Hodjegan, Jashvant D Unadkat

Br J Clin Pharmacol· March 2014

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Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.
J William Higgins, Jing Q Bao, Alice B Ke, Jason R Manro, John K Fallon

Drug Metab Dispos· January 2014

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A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.
Alice Ban Ke, Srikanth C Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen

Drug Metab Dispos· April 2013

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Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition.
Alice Ban Ke, Sara Eyal, Francisco S Chung, Jeanne M Link, David A Mankoff

J Nucl Med· March 2013

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