Publications by authors named "Andrew Waight"

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Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening.
Kevin James Metcalf, Galen Wo, Jan Paulo Zaragoza, Fahimeh Raoufi, Jeanne Baker, Andrew Waight

MAbs· December 2025

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AbLEF: antibody language ensemble fusion for thermodynamically empowered property predictions.
Zachary A Rollins, Talal Widatalla, Andrew Waight, Alan C Cheng, Essam Metwally

Bioinformatics· May 2024

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A machine learning strategy for the identification of key descriptors and prediction models for IgG monoclonal antibody developability properties.
Andrew B Waight, David Prihoda, Rojan Shrestha, Kevin Metcalf, Marc Bailly

MAbs· November 2023

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Codon Optimization Using a Recurrent Neural Network.
Dennis R Goulet, Yongqi Yan, Palak Agrawal, Andrew B Waight, Amanda Nga-Sze Mak

J Comput Biol· January 2023

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BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning.
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman

MAbs· April 2022

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ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern.
Tsung-I Tsai, Jahan S Khalili, Mark Gilchrist, Andrew B Waight, Daniella Cohen

Antiviral Res· March 2022

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Engineering an Enhanced EGFR Engager: Humanization of Cetuximab for Improved Developability.
Dennis R Goulet, Soumili Chatterjee, Wai-Ping Lee, Andrew B Waight, Yi Zhu

Antibodies (Basel)· January 2022

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Improving Antibody-Tubulysin Conjugates through Linker Chemistry and Site-Specific Conjugation.
Joseph Z Hamilton, Thomas A Pires, Jamie A Mitchell, Julia H Cochran, Kim K Emmerton, Andrew B Waight

ChemMedChem· April 2021

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Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models.
Philip N Moquist, Tim D Bovee, Andrew B Waight, Jamie A Mitchell, Jamie B Miyamoto

Mol Cancer Ther· February 2021

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Structure-activity relationships of tubulysin analogues.
Joel R Courter, Joseph Z Hamilton, Nathaniel R Hendrick, Margo Zaval, Andrew B Waight

Bioorg Med Chem Lett· July 2020

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Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates.
Christopher S Neumann, Kathleen C Olivas, Martha E Anderson, Julia H Cochran, Steven Jin, Andrew B Waight

Mol Cancer Ther· December 2018

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Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR and Heterogeneous Tumor Models.
Patrick J Burke, Joseph Z Hamilton, Thomas A Pires, Holden W H Lai, Christopher I Leiske, Andrew B Waight

Mol Cancer Ther· August 2018

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Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.
Andrew B Waight, Katja Bargsten, Svetlana Doronina, Michel O Steinmetz, Django Sussman

PLoS One· August 2017

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Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation.
Andrea E Prota, Jocelyn Setter, Andrew B Waight, Katja Bargsten, Juan Murga

J Mol Biol· July 2016

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Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates.
Patrick J Burke, Joseph Z Hamilton, Thomas A Pires, Jocelyn R Setter, Joshua H Hunter, Andrew B Waight

Mol Cancer Ther· May 2016

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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Khyati Kapoor, Janet S Finer-Moore, Bjørn P Pedersen, Laura Caboni, Andrew Waight

Proc Natl Acad Sci U S A· April 2016

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A previously undescribed tubulin binder.
Jessica J Field, Andrew B Waight, Peter D Senter

Proc Natl Acad Sci U S A· September 2014

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Ion selectivity and gating mechanisms of FNT channels.
Andrew B Waight, Bryan K Czyzewski, Da-Neng Wang

Curr Opin Struct Biol· August 2013

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Structural basis for alternating access of a eukaryotic calcium/proton exchanger.
Andrew B Waight, Bjørn Panyella Pedersen, Avner Schlessinger, Massimiliano Bonomi, Bryant H Chau

Nature· July 2013

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Crystal structure of a eukaryotic phosphate transporter.
Bjørn P Pedersen, Hemant Kumar, Andrew B Waight, Aaron J Risenmay, Zygy Roe-Zurz

Nature· April 2013

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Structure and mechanism of a pentameric formate channel.
Andrew B Waight, James Love, Da-Neng Wang

Nat Struct Mol Biol· January 2010

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Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering.
Daniel A Erlanson, Robert S McDowell, Molly M He, Mike Randal, Robert L Simmons, Andrew Waight

J Am Chem Soc· May 2003

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