Publications by authors named "Annabelle Lewis"

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BMP antagonist CHRDL2 enhances the cancer stem-cell phenotype and increases chemotherapy resistance in colorectal cancer.
Eloise Clarkson, Annabelle Lewis

Mol Oncol· November 2025

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BMP signalling in colorectal cancer: losing the yin to WNTs yang.
Eloise Clarkson, Annabelle Lewis

J Pathol· July 2025

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Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis.
Matthew Brown, Alicia Leon, Katarzyna Kedzierska, Charlotte Moore, Hayley L Belnoue-Davis, Annabelle Lewis

EMBO Mol Med· October 2023

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Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer.
Samanta Jerin, Amanda J Harvey, Annabelle Lewis

Cancers (Basel)· July 2023

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Alterations to Genome Organisation in Stem Cells, Their Differentiation and Associated Diseases.
Joanna M Bridger, Rita Torres Pereira, Cristina Pina, Sabrina Tosi, Annabelle Lewis

Results Probl Cell Differ· November 2022

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NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch.
Séan M O'Cathail, Chieh-Hsi Wu, Rachael Thomas, Maria A Hawkins, Tim S Maughan, Annabelle Lewis

Antioxidants (Basel)· August 2021

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Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability.
Holly Russell, Katarzyna Kedzierska, Daniel D Buchanan, Rachael Thomas, Emma Tham, Annabelle Lewis

Clin Epigenetics· April 2021

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NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer.
Séan M O'Cathail, Chieh-Hsi Wu, Annabelle Lewis, Chris Holmes, Maria A Hawkins

Cancer Genet· October 2020

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The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability.
Holly Russell, Katarzyna Kedzierska, Daniel D Buchanan, Rachael Thomas, Emma Tham, Annabelle Lewis

Clin Epigenetics· July 2020

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CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods.
Emily Rayner, Mary-Anne Durin, Rachael Thomas, Daniela Moralli, Sean M O'Cathail, Annabelle Lewis

CRISPR J· December 2019

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The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.
Rachael Thomas, Davide Trapani, Lily Goodyer-Sait, Marketa Tomkova, Ceres Fernandez-Rozadilla, Annabelle Lewis

Sci Rep· September 2019

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Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.
Ann-Marie Baker, Weini Huang, Xiao-Ming Mindy Wang, Marnix Jansen, Xiao-Jun Ma, Annabelle Lewis

Nat Commun· December 2017

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Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.
Shazia Irshad, Mukesh Bansal, Paolo Guarnieri, Hayley Davis, Ayman Al Haj Zen, Annabelle Lewis

J Pathol· June 2017

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Five endometrial cancer risk loci identified through genome-wide association analysis.
Timothy Ht Cheng, Deborah J Thompson, Tracy A O'Mara, Jodie N Painter, Dylan M Glubb, Annabelle Lewis

Nat Genet· June 2016

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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Hayley Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova, Annabelle Lewis

Nat Med· January 2015

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A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.
Annabelle Lewis, Luke Freeman-Mills, Elisa de la Calle-Mustienes, Rosa María Giráldez-Pérez, Hayley Davis

Cell Rep· August 2014

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Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines.
Hayley Davis, Annabelle Lewis, Axel Behrens, Ian Tomlinson

Gut· May 2014

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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.
Simon J Leedham, Pedro Rodenas-Cuadrado, Kimberley Howarth, Annabelle Lewis, Sreelakshmi Mallappa

Gut· January 2013

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Cancer. The utility of mouse models in post-GWAS research.
Annabelle Lewis, Ian Tomlinson

Science· December 2012

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Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
Emma Jaeger, Simon Leedham, Annabelle Lewis, Stefania Segditsas, Martin Becker

Nat Genet· May 2012

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The C-terminus of Apc does not influence intestinal adenoma development or progression.
Annabelle Lewis, Hayley Davis, Maesha Deheragoda, Patrick Pollard, Emma Nye

J Pathol· January 2012

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FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.
Hayley Davis, Annabelle Lewis, Bradley Spencer-Dene, Hilda Tateossian, Gordon Stamp

J Pathol· June 2011

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Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.
Ian P M Tomlinson, Luis G Carvajal-Carmona, Sara E Dobbins, Albert Tenesa, Angela M Jones, Annabelle Lewis

PLoS Genet· June 2011

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FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
Roya Babaei-Jadidi, Ningning Li, Anas Saadeddin, Bradley Spencer-Dene, Anett Jandke, Annabelle Lewis

J Exp Med· February 2011

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Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.
Annabelle Lewis, Stefania Segditsas, Maesha Deheragoda, Patrick Pollard, Rosemary Jeffery

Gut· December 2010

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