Publications by authors named "Anthony Slavin"

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Developmental Toxicology Profile of the IRAK4 Degrader KT-474.
Bradley E Enerson, Gregg Cappon, Yatao Shi, Dirk M Walther, Veronica Campbell, Anthony Slavin

Toxicol Sci· December 2025

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Pharmacokinetics and Pharmacodynamics of KT-474, a Novel Selective Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults.
Sagar Agarwal, Alice A McDonald, Veronica Campbell, Dapeng Chen, Jeff Davis, Anthony Slavin

Clin Transl Sci· March 2025

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IRAK4 Is Overexpressed in Hidradenitis Suppurativa Skin and Correlates with Inflammatory Biomarkers.
Alice McDonald, Rahul Karnik, Veronica Campbell, Jeff Davis, Sara Chavoshi, Anthony Slavin

J Invest Dermatol· February 2025

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Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.
Xiaozhang Zheng, Nan Ji, Veronica Campbell, Anthony Slavin, Xiao Zhu

J Med Chem· October 2024

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Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
Matthew M Weiss, Xiaozhang Zheng, Nan Ji, Chris M Browne, Veronica Campbell, Anthony Slavin

J Med Chem· July 2024

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Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms.
Matthew A Ciorba, Liza Konnikova, Simon A Hirota, Elena M Lucchetta, Jerrold R Turner, Anthony Slavin

Inflamm Bowel Dis· May 2024

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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial.
Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard Schwartz, Brian J Feinstein, Anthony Slavin

Nat Med· December 2023

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A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans.
Sarah C Edwards, Caroline E Sutton, Kristin Ladell, Emma J Grant, James E McLaren, Anthony Slavin

J Exp Med· May 2020

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Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses.
Peter F Slivka, Chen-Lin Hsieh, Alex Lipovsky, Steven D Pratt, John Locklear, Anthony Slavin

ACS Chem Biol· May 2019

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Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?
Scott S Zamvil, Anthony J Slavin

Neurol Neuroimmunol Neuroinflamm· February 2015

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MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.
Michel Varrin-Doyer, Aparna Shetty, Collin M Spencer, Ulf Schulze-Topphoff, Martin S Weber, Anthony J Slavin

Neurol Neuroimmunol Neuroinflamm· August 2014

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Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.
Aparna Shetty, Sheena G Gupta, Michel Varrin-Doyer, Martin S Weber, Thomas Prod'homme, Anthony J Slavin

Neurol Neuroimmunol Neuroinflamm· August 2014

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No differences observed among multiple clinical S1P1 receptor agonists (functional antagonists) in S1P1 receptor down-regulation and degradation.
Susan Lukas, Lori Patnaude, Sokol Haxhinasto, Anthony Slavin, Melissa Hill-Drzewi

J Biomol Screen· March 2014

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MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
Nicolas Molnarfi, Ulf Schulze-Topphoff, Martin S Weber, Juan C Patarroyo, Thomas Prod'homme, Anthony J Slavin

J Exp Med· December 2013

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Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.
Nuruddeen D Lewis, Sokol A Haxhinasto, Shawn M Anderson, Dimitria E Stefanopoulos, Steven E Fogal, Anthony J Slavin

J Immunol· April 2013

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Pathogenic mechanisms and experimental models of multiple sclerosis.
Anthony Slavin, Louise Kelly-Modis, Mark Labadia, Kelli Ryan, Maryanne L Brown

Autoimmunity· November 2010

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B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity.
Martin S Weber, Thomas Prod'homme, Juan C Patarroyo, Nicolas Molnarfi, Tara Karnezis, Anthony J Slavin

Ann Neurol· September 2010

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FTY720 and central memory: out of sight, out of mind.
Anthony J Slavin, Scott S Zamvil

Neurology· August 2010

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Transient expression of an IL-23R extracellular domain Fc fusion protein in CHO vs. HEK cells results in improved plasma exposure.
Ka Fai Suen, Mary S Turner, Feng Gao, Bo Liu, Alana Althage, Anthony Slavin

Protein Expr Purif· May 2010

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The growth factor Midkine antagonizes VEGF signaling in vitro and in vivo.
Edward Htun van der Horst, Brendon T Frank, Lawrence Chinn, Angela Coxon, Shyun Li, Anthony Slavin

Neoplasia· April 2008

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Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice.
Christian Stremmel, Wulf Sienel, Stephan Eggeling, Bernward Passlick, Anthony Slavin

Eur J Cardiothorac Surg· August 2006

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Characterization of gene expression profiles of T cells during anti-tumor response.
Christian Stremmel, Renate Siebenhaar, Roland Croner, Bertram Reingruber, Anthony J Slavin

Int J Colorectal Dis· November 2005

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Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.
Edward Htun van der Horst, Yan Y Degenhardt, Astrid Strelow, Anthony Slavin, Lawrence Chinn

Proc Natl Acad Sci U S A· November 2005

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G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway.
Ming Yang, Wendy W Zhong, Neelam Srivastava, Anthony Slavin, Jianxin Yang

Proc Natl Acad Sci U S A· April 2005

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Treatment of autoimmune disease by adoptive cellular gene therapy.
Ingo H Tarner, Anthony J Slavin, Jacqueline McBride, Alenka Levicnik, Richard Smith

Ann N Y Acad Sci· September 2003

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